Effect of tidal volume and end tracheal tube leakage on end-tidal CO2in very low birth weight infants
- 1 January 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Journal of Perinatology
- Vol. 41 (1), 47-52
- https://doi.org/10.1038/s41372-020-0758-2
Abstract
Objective To examine the extents to which low tidal volume (VT) and endotracheal tube (ETT) leakeage influence the accuracy of ETCO(2)for estimating arterial PCO2(PaCO2) in very low birth weight (VLBW) infants with mechanical ventilation. Study design An observational study. We evaluated a total of 287 paired ETCO(2)and PaCO(2)values as well as VTs obtained from 22 VLBW infants with ventilation. Deming regression, quadratic discriminant analysis, and Bland-Altman analysis were performed. Result ETCO(2)and PaCO(2)were correlated (r(2) = 0.5897,p < 0.0001). A quadratic discrimination analysis of the VT and the percentage of leak yielded 70.4% [95%CI, 65.1 to 75.7] discrimination for the agreement between ETCO(2)and PaCO2. ETCO(2)was strongly correlated with PaCO(2)in the discriminant functionZ > 0 group (r(2) = 0.7234,p < 0.0001). Conclusion Our results indicate that ETCO(2)is a good surrogate for PaCO(2)when VT is high and ETT leak is low.This publication has 27 references indexed in Scilit:
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