Effectiveness and safety of acupuncture and moxibustion for defecation dysfunction after sphincter-preserving surgery for rectal cancer: protocol for systematic review and meta-analysis
Open Access
- 6 May 2020
- Vol. 10 (5), e034152
- https://doi.org/10.1136/bmjopen-2019-034152
Abstract
Introduction Defecation dysfunction (DD) is one of the most common complications following sphincter-preserving surgery for rectal cancer. And there is no effective treatment of DD after sphincter-preserving surgery for rectal cancer. Although some studies suggested that acupuncture and moxibustion (AM) is effective and safe for DD after sphincter-preserving surgery for rectal cancer, lacking strong evidence, for instance, the relevant systematic review, meta-analysis and randomised controlled trial (RCT) of a large, multicentre sample, makes the effects and safety remain uncertain. The present protocol is described for a systematic review and meta-analysis to investigate the effectiveness and safety of AM for DD after sphincter-preserving surgery for rectal cancer. Methods and analysis We will search nine online databases from inception to 1 October 2019; the language of included trials will not be restricted. This study will include RCTs that performed AM as the main method of the experimental group for patients with DD after sphincter-preserving surgery for rectal cancer. Two of the researchers will independently select the studies, conduct risk of bias assessment and extract the data. We will use the fixed-effects model or random-effects model of RevMan V.5.2 software to analyse data synthesis. The risk ratios with 95% CIs and weighted mean differences or standardised mean differences with 95% CIs will be used to present the data synthesis outcome of dichotomous data respectively and the continuous data. Evidence quality of outcome will be assessed by using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. Ethics and dissemination Ethical approval is not required in this secondary research evidence, and we will publish the results of this study in a journal or concerned conferences. Trial registration number CRD42019140097.Funding Information
- National Natural Science Foundation of China (81590950)
This publication has 42 references indexed in Scilit:
- Comparison of Colonic J-pouch and Straight Coloanal anastomosis after Low Anterior ResectionIranian Red Crescent Medical Journal, 2013
- The Long-term Gastrointestinal Functional Outcomes Following Curative Anterior Resection in Adults With Rectal Cancer: A Systematic Review and Meta-analysisDiseases of the Colon & Rectum, 2011
- The Cochrane Collaboration's tool for assessing risk of bias in randomised trialsBMJ, 2011
- Treatment of the adverse effects from acupuncture and their economic impact: A prospective study in 73,406 patients with low back or neck painEuropean journal of pain, 2011
- GRADE: an emerging consensus on rating quality of evidence and strength of recommendationsBMJ, 2008
- Therapeutic roles of acupuncture in functional gastrointestinal disordersAlimentary Pharmacology & Therapeutics, 2004
- Vagal input to the enteric nervous systemGut, 2000
- Sympathetic input into the enteric nervous systemGut, 2000
- Misconceptions about the colonic J-pouchDiseases of the Colon & Rectum, 1999
- Decrease in the anorectal pressure gradient after low anterior resection of the rectumDiseases of the Colon & Rectum, 1994