False-Positive 18F–Prostate-Specific Membrane Antigen–1007 PET/CT Caused by Hepatic Multifocal Inflammatory Foci
- 24 November 2020
- journal article
- editorial
- Published by Ovid Technologies (Wolters Kluwer Health) in Clinical Nuclear Medicine
- Vol. 46 (2), e80-e83
- https://doi.org/10.1097/rlu.0000000000003425
Abstract
A 68-year-old man with history of treated prostate cancer was referred to 68Ga–prostate-specific membrane antigen (PSMA)–11 PET/CT imaging. Moderate bone involvement was observed, with a normal liver tracer uptake. Bone biopsy confirmed metastases of prostate cancer. After therapy adjustment, a follow-up 18F-PSMA-1007 PET/CT revealed good response in bone lesions, although it showed 3 new rounded liver intense uptake foci. Concurrent PSA was 0.6 ng/mL. Liver function tests were normal. PET/CT-guided hepatic biopsy demonstrated no malignant cells, focal inflammation, and steatosis, being possibly the inflammation the cause of false-positive multifocal uptake of 18F-PSMA-1007. Following PET/CT, controls showed a normal liver.Keywords
This publication has 9 references indexed in Scilit:
- Nonprostatic diseases on PSMA PET imaging: a spectrum of benign and malignant findingsCancer Imaging, 2020
- Matched-Pair Comparison of 68Ga-PSMA-11 PET/CT and 18F-PSMA-1007 PET/CT: Frequency of Pitfalls and Detection Efficacy in Biochemical Recurrence After Radical ProstatectomyJournal of Nuclear Medicine, 2019
- Pitfalls in Gallium-68 PSMA PET/CT Interpretation—A Pictorial ReviewTomography, 2018
- 68Ga-PSMA PET/CT in prostate cancer patients – patterns of disease, benign findings and pitfallsCancer Imaging, 2018
- Prostate-specific Membrane Antigen PET: Clinical Utility in Prostate Cancer, Normal Patterns, Pearls, and PitfallsRadioGraphics, 2018
- Pearls and pitfalls in clinical interpretation of prostate-specific membrane antigen (PSMA)-targeted PET imagingEuropean Journal of Nuclear Medicine and Molecular Imaging, 2017
- A Comprehensive Approach to Hepatic Vascular DiseaseRadioGraphics, 2017
- F-18 labelled PSMA-1007: biodistribution, radiation dosimetry and histopathological validation of tumor lesions in prostate cancer patientsEuropean Journal of Nuclear Medicine and Molecular Imaging, 2016
- Understanding Transient Hepatic Attenuation DifferencesSeminars in Ultrasound, CT and MRI, 2009