Exosome-Mediated Drug Delivery for Cell-Free Therapy of Osteoarthritis
- 1 September 2021
- journal article
- review article
- Published by Bentham Science Publishers Ltd. in Current Medicinal Chemistry
- Vol. 28 (31), 6458-6483
- https://doi.org/10.2174/0929867327666201118161232
Abstract
Osteoarthritis (OA) is a degenerative disease of cartilage and bones, which results in severely compromised quality of life in the aged population. However, currently no ideal treatment strategies have been developed to prevent the OA progression. Cell therapies such as chondrocyte and MSC transplantation have been extensively tested and evaluated in clinical trials. Yet, until to date, the clinical efficacy of articular injection of stem cells in OA has not been convincingly demonstrated. Recent studies have indicated that exosomes, one type of Extracellular Vesicles (EVs) play an important regulatory role in the pathogenesis of OA, suggesting the prospective therapeutic application of exosomes in OA treatment. In this review, we systematically summarized the paracrine effects of exosomes derived from MSCs and chondrocytes on cartilage regeneration, the use of exosomes as a delivery vehicle for OA treatment, the effectiveness of such treatments in OA animal models, and future perspective of exosome-mediated drug delivery as a cell-free therapy of OA.Keywords
Funding Information
- Science and Technology Planning Project of Shenzhen Municipality (KQTD20170331100838136, JCYJ20170817172023838, JCYJ20170306092215436, JCYJ20170413161649437)
- Key Program of Natural Science Foundation of Guangdong Province (2018B0303110003)
- National Natural Science Foundation of China (81772394, 81972116)
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