Pro‐inflammatory role of cell‐free mitochondrial DNA in cardiovascular diseases
- 13 July 2020
- journal article
- review article
- Published by Wiley in IUBMB Life
- Vol. 72 (9), 1879-1890
- https://doi.org/10.1002/iub.2339
Abstract
Cardiovascular disease (CVD) is a major cause of morbidity and mortality. Inflammation contributes to the pathogenesis and progression of CVD. Circulating cell‐free mitochondrial DNA (ccf‐mtDNA) is that mtDNA fragments are released outside the cell and into the circulation by cell necrosis and secretion. The levels of ccf‐mtDNA are increased in CVD and associated risk conditions, including hypercholesterolemia, diabetes mellitus, and arterial hypertension. MtDNA containing unmethylated CpG dinucleotides and can trigger inflammation that aggravates tissue injury by activating toll‐like receptor 9, inflammasomes, and the stimulator of interferon genes pathway. Here, we review the expanding field of ccf‐mtDNA‐mediated inflammation and its role in the progression of CVD.Keywords
This publication has 118 references indexed in Scilit:
- Myocardial infarction causes inflammation and leukocyte recruitment at remote sites in the myocardium and in the renal glomerulusInflammation Research, 2013
- Oxidant stress in mitochondrial DNA damage, autophagy and inflammation in atherosclerosisScientific Reports, 2013
- Ceramide targets autophagosomes to mitochondria and induces lethal mitophagyNature Chemical Biology, 2012
- Mitochondrial DNA that escapes from autophagy causes inflammation and heart failureNature, 2012
- Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during ApoptosisImmunity, 2012
- Nucleic Acid Recognition by the Innate Immune SystemAnnual Review of Immunology, 2011
- Nucleolin-Mediated Cellular Trafficking of DNA Nanoparticle Is Lipid Raft and Microtubule Dependent and Can Be Modulated by GlucocorticoidMolecular Therapy, 2011
- Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasomeNature Immunology, 2010
- Inflammatory cytokines in vascular dysfunction and vascular diseaseBiochemical Pharmacology, 2009
- Immune and Inflammatory Mechanisms of AtherosclerosisAnnual Review of Immunology, 2009