Measurement properties of the one-minute sit-to-stand test in children and adolescents with cystic fibrosis: A multicenter randomized cross-over trial
Open Access
- 12 February 2021
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 16 (2), e0246781
- https://doi.org/10.1371/journal.pone.0246781
Abstract
Functional exercise capacity assessment is recommended in children with cystic fibrosis (CF). The six-minute walk test (6MWT) is a valid evaluation of exercise capacity but can be technically complex. Inversely, the sit-to-stand test (STST) is a simple method to evaluate exercise capacity, and is validated in healthy children and adults with CF. This study aimed to evaluate STST measurement properties in children and adolescents with CF. In this multicenter study, children with CF (6 to 18 years) performed two iterations of both the STST and the 6MWT in a randomized order. Criterion validity was determined by assessing correlations between STST repetitions and 6MWT distance (6MWD). Intra-rater reliability, test-retest repeatability, mean bias and limits of agreement were also assessed. Relationships with other outcomes (i.e. respiratory and quadriceps muscle strength) and cardio-respiratory responses were analysed for both tests. Thirty-six children with CF were included (mean age 12.0 ±3.5 years and FEV1 95.8 ±25.0%). On average, 39.6 ±10.5 repetitions were performed during the STST and mean 6MWD was 596.0 ±102.6 meters. STST number of repetitions was significantly correlated with 6MWD (r = 0.48; pSTST = 0.91 (95%CI 0.76–0.96) and ICC6MWT = 0.94 (95%CI 0.85–0.97)), and a significant test-retest learning effect. The number of STST repetitions was not correlated with quadriceps or respiratory muscle strength test, and the STST induced fewer cardio-respiratory responses than the 6MWT. The STST is an easy-to-use functional test with moderate criterion validity when compared to the 6MWT in children with CF, probably because both tests measure different components of functional exercise capacity. The STST is useful when the 6MWT is unfeasible, however further investigations are required to explore the clinical implications of STST results in children with CF. NCT03069625.This publication has 39 references indexed in Scilit:
- Respiratory muscle strength in stable adolescent and adult patients with cystic fibrosisJournal of Cystic Fibrosis, 2009
- Skeletal muscle weakness, exercise tolerance and physical activity in adults with cystic fibrosisEuropean Respiratory Journal, 2009
- Assigning Energy Costs to Activities in ChildrenMedicine & Science in Sports & Exercise, 2008
- Comparison of the Sit-to-Stand Test with 6min walk test in patients with chronic obstructive pulmonary diseaseRespiratory Medicine, 2007
- Six‐minute walk test in children and adolescents with cystic fibrosisPediatric Pulmonology, 2006
- Standardisation of spirometryEuropean Respiratory Journal, 2005
- Exercise testing and training in German CF centersPediatric Pulmonology, 2004
- A six-minute walk test for assessing exercise tolerance in severely ill childrenThe Journal of Pediatrics, 1996
- Applied Statistics for the Behavioral SciencesJournal of Educational Statistics, 1990
- STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENTThe Lancet, 1986