Age-Related Macular Degeneration: What Do We Know So Far?
Open Access
- 18 January 2021
- journal article
- review article
- Published by Vilnius University Press in Acta medica Lituanica
- Vol. 28 (1), 7
- https://doi.org/10.15388/amed.2021.28.1.7
Abstract
Ageing is a natural process that everyone experiences and nobody is an exception. With ageing, our body experiences physiological changes. In this article, the focus is made on the physiological changes of our eyes related to ageing and age-related macular degeneration (AMD), which is the most common cause of incurable visual impairment in developed countries. With ageing populations increasing in many countries, more and more patients will have AMD in a foreseeable future. In Eastern Europe, blindness due to AMD, currently, is approximately 20% and there has been an increasing trend depicted in the future. Generally, AMD can be divided into early stages and two forms in an advanced (late) stage. Advanced AMD form includes neovascular AMD (wet) and geographic atrophy (late dry), both of these are associated with substantial, progressive visual impairment. The pathogenesis of AMD is complex and, by far, not completely understood. Multiple factors have been studied, for example: environmental factor, genetic factor (complement factor H), lifestyle. It has been proved that they are linked to higher the risk of developing of AMD, however, the actual pathogenesis is not yet formulated. AMD progression can also be a culprit to certain biochemical events and molecular changes linked to inflammation and pathological angiogenesis. In nowadays, we do have diagnostic methods for both early and late forms of AMD as well as ways to prevent progression of early AMD and wet AMD. However, until now, there is still no treatment for dry AMD. This article is a brief review of AMD and may hopefully lead to some future directions in early diagnostic methods and treating dry AMD.Keywords
This publication has 103 references indexed in Scilit:
- Laser in situ keratomileusis for astigmatism ≤ 0.75 Diopter combined with low myopia: a retrospective data analysisBMC Ophthalmology, 2014
- Long-Term Blood Pressure and Age-Related Macular Degeneration: The ALIENOR StudyInvestigative Ophthalmology & Visual Science, 2013
- Mechanism of Inflammation in Age-Related Macular DegenerationMediators of Inflammation, 2012
- Embryonic stem cell trials for macular degeneration: a preliminary reportThe Lancet, 2012
- Racial Differences in Age-Related Macular Degeneration Rates in the United States: A Longitudinal Analysis of a Managed Care NetworkAmerican Journal of Ophthalmology, 2011
- Effect of dietary, social, and lifestyle determinants of accelerated aging and its common clinical presentation: A survey studyAyu, 2011
- Unfolding the therapeutic potential of chemical chaperones for age-related macular degenerationExpert Review of Ophthalmology, 2008
- Haplotypes in the Complement Factor H (CFH) Gene: Associations with Drusen and Advanced Age-Related Macular DegenerationPLOS ONE, 2007
- In vivospectrofluorimetry reveals endogenous biomarkers that report healthspan and dietary restriction inCaenorhabditis elegansAging Cell, 2005
- Early-Onset Macular Degeneration with Drusen in a Cynomolgus Monkey (Macaca fascicularis) Pedigree: Exclusion of 13 Candidate Genes and LociInvestigative Ophthalmology & Visual Science, 2005