Impact of Bicarbonate on PBP2a Production, Maturation, and Functionality in Methicillin-Resistant Staphylococcus aureus
Open Access
- 19 April 2021
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 65 (5)
- https://doi.org/10.1128/aac.02621-20
Abstract
Certain methicillin-resistant Staphylococcus aureus (MRSA) strains exhibit β-lactam susceptibility in vitro , ex vivo , and in vivo in the presence of NaHCO 3 (NaHCO 3 -responsive MRSA). Here, we investigate the impact of NaHCO 3 on factors required for PBP2a functionality.Funding Information
- HHS | National Institutes of Health (1R01-AI146078)
- HHS | National Institutes of Health (1R01-AI139244)
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