Estimating the biological effects of helium, carbon, oxygen, and neon ion beams using 3D silicon microdosimeters
- 23 December 2020
- journal article
- research article
- Published by IOP Publishing in Physics in Medicine & Biology
- Vol. 66 (4), 045017
- https://doi.org/10.1088/1361-6560/abd66f
Abstract
In this study, the survival fraction (SF) and relative biological effectiveness (RBE) of pancreatic cancer cells exposed to spread-out Bragg peak (SOBP) helium, carbon, oxygen, and neon ion beams are estimated from the measured microdosimetric spectra using a microdosimeter and the application of the microdosimetric kinetic (MK) model. To measure the microdosimetric spectra, a 3D mushroom silicon-on-insulator (SOI) microdosimeter connected to low noise readout electronics (MicroPlus probe) was used. The parameters of the MK model were determined for pancreatic cancer cells such that the calculated SFs reproduced previously reported in vitro SF data. For a cuboid target of 10×10×6 cm3, treatment plans of helium, carbon, oxygen, and neon ion beams were designed using in-house treatment planning software (TPS) to achieve a 10% SF of pancreatic cancer cells throughout the target. The physical doses and microdosimetric spectra of the planned fields were measured at different depths in polymethyl methacrylate (PMMA) phantoms. The biological effects, such as SF, RBE, and RBE-weighted dose at different depths along the fields were predicted from the measurements. The predicted SFs at the target region were generally in good agreement with the planned SF from the TPS in most cases.This publication has 25 references indexed in Scilit:
- Helium ions for radiotherapy? Physical and biological verifications of a novel treatment modalityMedical Physics, 2016
- Novel detectors for silicon based microdosimetry, their concepts and applicationsNuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2016
- Reformulation of a clinical-dose system for carbon-ion radiotherapy treatment planning at the National Institute of Radiological Sciences, JapanPhysics in Medicine & Biology, 2015
- Evaluation of hybrid depth scanning for carbon‐ion radiotherapyMedical Physics, 2012
- Treatment planning for a scanned carbon beam with a modified microdosimetric kinetic modelPhysics in Medicine & Biology, 2010
- Performance of the NIRS fast scanning system for heavy‐ion radiotherapyMedical Physics, 2010
- Measurement of microdosimetric spectra with a wall-less tissue-equivalent proportional counter for a 290 MeV/u12C beamPhysics in Medicine & Biology, 2010
- Microdosimetric Measurements and Estimation of Human Cell Survival for Heavy-Ion BeamsRadiation Research, 2006
- Treatment planning for heavy-ion radiotherapy: physical beam model and dose optimizationPhysics in Medicine & Biology, 2000
- Irradiation of Mixed Beam and Design of Spread-Out Bragg Peak for Heavy-Ion RadiotherapyRadiation Research, 1997