Poor Sleep Is Related to Metabolic Syndrome Severity in Adolescents With PCOS and Obesity
- 4 January 2020
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 105 (4), e1827-e1834
- https://doi.org/10.1210/clinem/dgz285
Abstract
Context Polycystic ovary syndrome (PCOS) is a common endocrine disorder and is associated with metabolic syndrome (MS). Development of MS in PCOS is likely multifactorial and may relate to poor sleep. Objective The objective of this research is to investigate differences in objective markers of sleep in adolescents with obesity and PCOS with and without MS. We also aimed to examine the relationships between markers of sleep with MS markers. Design A cross-sectional study was conducted. Participants Participants included adolescents with PCOS and obesity with MS (N = 30) or without MS (N = 36). Outcome Measures Hormone and metabolic measurements, abdominal magnetic resonance imaging for hepatic fat fraction, actigraphy to estimate sleep, and overnight polysomnography (PSG). Results Adolescents with obesity and PCOS who also had MS had significantly worse sleep-disordered breathing including higher apnea-hypopnea index (AHI, P = .02) and arousal index (P = .01) compared to those without MS. Actigraphy showed no differences in habitual patterns of sleep behaviors including duration, timing, or efficiency between groups. However, a greater number of poor sleep health behaviors was associated with greater number of MS components (P = .04). Higher AHI correlated with higher triglycerides (TG) (r = 0.49, P = .02), and poorer sleep efficiency correlated with higher percentage of liver fat (r = –0.40, P = .01), waist circumference (r = –0.46, P < .01) and higher TG (r = –0.34, P = .04). Conclusions Among girls with PCOS and obesity, sleep-disordered breathing was more prevalent in those with MS, and poor sleep behaviors were associated with metabolic dysfunction and more MS symptoms. Sleep health should be included in the assessment of adolescents with PCOS and obesity.Keywords
Funding Information
- National Institutes of Health (K12HD057022)
- National Institute of Diabetes and Digestive and Kidney Diseases (K23DK107871)
- Doris Duke Foundation Caregivers Fellowship
- Children's Hospital Colorado Research Institute
- University of Colorado Denver Center for Women’s Health Research
- National Center for Advancing Translational Sciences (UL1TR002535)
This publication has 45 references indexed in Scilit:
- Sleep and cardiometabolic function in obese adolescent girls with polycystic ovary syndromeSleep Medicine, 2012
- Screening for Sleep-Disordered Breathing and Excessive Daytime Sleepiness in Adolescent Girls with Polycystic Ovarian SyndromeThe Journal of Pediatrics, 2011
- A Comparison of Polysomnographic Variables Between Adolescents with Polycystic Ovarian Syndrome with and without the Metabolic SyndromeMetabolic Syndrome and Related Disorders, 2011
- Systematic review: association of polycystic ovary syndrome with metabolic syndrome and non-alcoholic fatty liver diseaseAlimentary Pharmacology & Therapeutics, 2011
- Relationships between polysomnographic variables, parameters of glucose metabolism, and serum androgens in obese adolescents with polycystic ovarian syndromeJournal of Sleep Research, 2010
- Insulin Resistance in Adolescents with Type 2 Diabetes Is Associated with Impaired Exercise CapacityJournal of Clinical Endocrinology & Metabolism, 2009
- A comprehensive definition for metabolic syndromeDisease Models & Mechanisms, 2009
- Sleepless in America: Inadequate Sleep and Relationships to Health and Well-being of Our Nation's ChildrenPEDIATRICS, 2007
- The Impact of School Daily Schedule on Adolescent SleepPEDIATRICS, 2005
- Validation of surrogate estimates of insulin sensitivity and insulin secretion in children and adolescentsThe Journal of Pediatrics, 2004