Palladium-catalyzed remote para-C-H activation of arenes assisted by a recyclable pyridine-based template
Open Access
- 21 March 2021
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Science
- Vol. 12 (11), 4126-4131
- https://doi.org/10.1039/d0sc07042d
Abstract
Direct para-selective C-H functionalization of arenes remains a daunting challenge and is still significantly restricted to a few scaffolds. Herein, we report an unprecedented pyridine-based para-directing template (DT) assisted, Pd-catalyzed para-C-H alkenylation of three classes of arenes, i.e. phenylpropanoic acids, 2-phenyl benzoic acids and benzyl alcohols, with a series of alkenes including perfluoroalkenes. Notably, the pyridine-based para-DT could be easily synthesized and readily recycled under mild conditions. These results may find application in rapid construction of para-substituted arenes and stimulate the exploration of novel methods for para-C-H functionalization of arenes.Funding Information
- Natural Science Foundation of Fujian Province (2020J02008)
- Youth Innovation Promotion Association of the Chinese Academy of Sciences (2020306)
- National Natural Science Foundation of China (21871257, 22022111, 22071248)
- Chinese Academy of Sciences (XDB20000000)
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