Maternal yeast‐based nucleotide supplementation decreased stillbirth by regulating nutrient metabolism

Abstract

BACKGROUND As an enzymatic product of yeast, yeast‐based nucleotide (YN) is rich in nucleotides. To test the effects of maternal dietary supplementation with YN during late pregnancy on placental nutrient transport, and nutrient metabolism of neonatal piglets, sixty‐four pregnant sows (day 85 ± 3) were assigned into two groups:(1) control (CON) and (2) treatment (YN, 4 g kg⁻¹). Blood, placenta, and liver samples of neonates during delivery were collected. RESULTS Results showed that maternal YN supplementation decreased stillbirth rate and intra‐uterine growth restriction rate (PPPSLC28A3, SLC29A1, SLC29A2, PC, PCK1, FBP1, SREBP1c, HSL, and CYP7a1 of neonatal piglets (P EAAT2, EAAT3, LAT1, and PAT1, and lower protein expression of PPARγ, AKT, phosphorylated‐AKT, phosphorylated‐mTOR and Raptor were observed in the YN group (P<0.05). CONCLUSION Together, these results indicated that maternal YN supplementation regulated placental nutrients transport by regulating the mTORC1‐PPARs pathway, and affected liver metabolism of nucleotides, amino acids, and fatty acids in neonatal piglets, thereby improving the reproductive performance of sow to a certain extent.