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Copper-Catalyzed Multicomponent Trifluoromethylphosphorothiolation of Alkenes: Access to CF3-Containing Alkyl Phosphorothioates

, Guo Yu, Wenwu Li, Zhigang Shu, Longyu Wang, Zhaoting Li, Xia Gao
Published: 12 July 2021

Abstract: An unprecedented copper-catalyzed multicomponent radical-based reaction involving alkenes, P(O)H compounds, sulfur powder, and Togni reagent II at room temperature has been developed. A variety of highly functionalized CF3-containing S-alkyl phosphorothioates can be directly prepared from a wide range of activated and unactivated alkenes. Moreover, this protocol highlights its potential in the late-stage functionalization of complex molecules and opens up a new avenue for the construction of C(sp3)–S–P bonds.
Keywords: functionalization / multicomponent / alkenes / CF3 / Alkyl / phosphorothioates / copper / sulfur / unactivated / sp3

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