Winnie-APCMin/+ Mice: A Spontaneous Model of Colitis-Associated Colorectal Cancer Combining Genetics and Inflammation
Open Access
- 23 April 2020
- journal article
- research article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 21 (8), 2972
- https://doi.org/10.3390/ijms21082972
Abstract
(1) Background: Colorectal cancer (CRC) is among the best examples of the relationship between inflammation and increased cancer risk. (2) Methods: To examine the effects of spontaneous low-grade chronic inflammation on the pathogenesis of CRC, we developed a new murine model of colitis-associated cancer (CAC) by crossing Mucin 2 mutated mice (Winnie) with ApcMin/+ mice. (3) Results: The resulting Winnie-ApcMin/+ model combines an inflammatory background with a genetic predisposition to small intestinal polyposis. Winnie-ApcMin/+ mice show an early occurrence of inflammatory signs and dysplastic lesions in the distal colon with a specific molecular signature. (4) Conclusion: The Winnie-ApcMin/+ model is a perfect model to demonstrate that chronic inflammation represents a crucial risk factor for the onset and progression of tumoral lesions in individuals genetically predisposed to CRC.Funding Information
- Ministero della Salute (Ricerca Corrente 2019, GR-2011-02347991, GR-2009-1470633)
- Regione Puglia (SiCURA "Soluzioni Innovative per la gestione del paziente e il follow up terapeutico della Colite Ulcerosa", PON - Ricerca e Innovazione 2014 - 2020: AIM1801289 - attività 3 linea 1)
- Regione Campania (PO FESR 2014-2020 - "Piattaforme tecnologiche di ricerca collaborativa per la lotta alle patologie oncologiche")
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