Are Nutraceuticals Beneficial in Chronic Kidney Disease?
Open Access
- 6 February 2021
- journal article
- review article
- Published by MDPI AG in Pharmaceutics
- Vol. 13 (2), 231
- https://doi.org/10.3390/pharmaceutics13020231
Abstract
Chronic kidney disease (CKD) is a worldwide health problem in which prevalence is constantly rising. The pathophysiology of CKD is complicated and has not been fully resolved. However, elevated oxidative stress is considered to play a vital role in the development of this disease. CKD is also thought to be an inflammatory disorder in which uremic toxins participate in the development of the inflammatory milieu. A healthy, balanced diet supports the maintenance of a good health status as it helps to reduce the risk of the development of chronic diseases, including chronic kidney disease, diabetes mellitus, and hypertension. Numerous studies have demonstrated that functional molecules and nutrients, including fatty acids and fiber as well as nutraceuticals such as curcumin, steviol glycosides, and resveratrol not only exert beneficial effects on pro-inflammatory and anti-inflammatory pathways but also on gut mucosa. Nutraceuticals have attracted great interest recently due to their potential favorable physiological effects on the human body and their safety. This review presents some nutraceuticals in which consumption could exert a beneficial impact on the development and progression of renal disease as well cardiovascular disease.This publication has 199 references indexed in Scilit:
- Effects of robotic guidance on the coordination of locomotionJournal of NeuroEngineering and Rehabilitation, 2013
- Genetic Variants and Associations of 25-Hydroxyvitamin D Concentrations With Major Clinical OutcomesJAMA, 2012
- Vitamin D Therapy and Cardiac Structure and Function in Patients With Chronic Kidney DiseaseJAMA, 2012
- Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysisThe Lancet, 2010
- Regulation of PPARγ function by TNF-αBiochemical and Biophysical Research Communications, 2008
- Prevalence of Chronic Kidney Disease in the United StatesJAMA, 2007
- Sirtuin activators mimic caloric restriction and delay ageing in metazoansNature, 2004
- Longitudinal Follow-up and Outcomes Among a Population With Chronic Kidney Disease in a Large Managed Care OrganizationArchives of Internal Medicine, 2004
- Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespanNature, 2003
- The elephant in uremia: Oxidant stress as a unifying concept of cardiovascular disease in uremiaKidney International, 2002