Acetaminophen interference with Nova StatStrip® Glucose Meter: case report with bench top confirmation
- 1 November 2020
- journal article
- research article
- Published by Taylor & Francis Ltd in Clinical Toxicology
- Vol. 58 (11), 1067-1070
- https://doi.org/10.1080/15563650.2020.1732404
Abstract
Context: Point-of-care glucose meters are an integral part in the assessment of patients with altered mental status. For this reason, glucose meters are checked for interference from commonly encountered substances, including acetaminophen. The Nova StatStrip(R) glucose meter has previously been reported to be resistant to interference. We report a case of a very high acetaminophen concentration causing interference with this point-of-care glucose meter. Case report: A 25-year-old female presented after an overdose of acetaminophen and diphenhydramine combination product. Patient was minimally responsive, so a point-of-care glucose check was attempted using the Nova StatStrip(R) glucose meter. Five different meters were attempted, and each showed an error message. Laboratory analysis using Beckman Coulter(R) Unicel DxC 800 revealed a glucose of 180 mg/dL and an acetaminophen concentration of 465 mg/L. Serum spiked with acetaminophen at different concentrations revealed interference with the Nova StatStrip(R) glucose meter at a concentration of 399 mg/L and above. To our knowledge, this interference with the Nova StatStrip(R) glucose meter has not been reported in the medical literature. Conclusion: Very high levels of acetaminophen can interfere with point-of-care glucose meters, even those that have previously been reported to be robust such as the Nova StatStrip(R) glucose meter. Clinicians should be aware of this possible interference when treating patients with acetaminophen overdose.This publication has 10 references indexed in Scilit:
- A Milestone in Point of Care Capillary Blood Glucose Monitoring of Critically Ill Hospitalized PatientsJournal of Diabetes Science and Technology, 2018
- 2017 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 35th Annual ReportClinical Toxicology, 2018
- nullPhilosophy Study, 2016
- Clinical Impact of Accurate Point-of-Care Glucose Monitoring for Tight Glycemic Control in Severely Burned Children*Pediatric Critical Care Medicine, 2016
- Evaluation of two glucose meters and interference corrections for screening neonatal hypoglycemiaPediatrics International, 2015
- Comparative Performance Assessment of Point-of-Care Testing Devices for Measuring Glucose and Ketones at the Patient BedsideJournal of Diabetes Science and Technology, 2014
- Factors Interfering With the Accuracy of Five Blood Glucose Meters Used in Chinese HospitalsJournal of Clinical Laboratory Analysis, 2013
- Emergency Department Visits for Overdoses of Acetaminophen-Containing ProductsAmerican Journal of Preventive Medicine, 2011
- Performance of a new interference-resistant glucose meterClinical Biochemistry, 2010
- CorrespondenceAnaesthesia and Intensive Care, 2003