Lithium compound catalyzed deoxygenative hydroboration of primary, secondary and tertiary amides
- 8 February 2021
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Dalton Transactions
- Vol. 50 (7), 2354-2358
- https://doi.org/10.1039/d1dt00364j
Abstract
A selective and efficient route for the deoxygenative reduction of primary to tertiary amides to corresponding amines has been achieved with pinacolborane (HBpin) using simple and readily accessible 2,6-di-tert-butyl phenolate lithium·THF (1a) as a catalyst. Both experimental and DFT studies provide mechanistic insight.Keywords
Funding Information
- Science and Engineering Research Board (CRG/2018/000287)
- Council of Scientific and Industrial Research, India (YSA000726)
- Indian Institute of Science Education and Research Pune
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