ASIAN JOURNAL OF PHARMACEUTICS

Journal Information
ISSN / EISSN: 09738398 / 1998409X
Total articles ≅ 337

Latest articles in this journal

Rajendra Chauhan
Published: 1 June 2022
ASIAN JOURNAL OF PHARMACEUTICS, Volume 16; https://doi.org/10.22377/ajpmds

Abstract:
Aim: The main aim of this study was to Formulation and Characterization of Repaglinide Transdermal Patch Using Natural polymers. Materials and Methods: The Box–Behnken design was used, which has three levels and three factors to investigate the associate impact of significant attributes on tensile strength, In vitro drug release, and Ex vivo drug permeation. Fifteen formulations were developed that differed in the polymer ratio (9:1, 8:1, and 7:1). The permeation of repaglinide through hairless goat ear skin through Ex vivo was found to increase with the help of permeation enhancer d-limonene. Results: As per the experimental data, it is concluded that the R12 is the best formulation in ex vivo permeation, in which we have taken 30% propylene glycol as a plasticizer, 3% d-limonene as a permeation enhancer, and this formulation shown 301.825 μg/cm2 permeation in 24 h. Conclusion: After optimizing all formulations, it concluded that the ratio of polymer in 9:1, 3% of a permeation enhancer, and 30% plasticize was the optimum quantity of different excipients used in the optimized formulation. These findings suggest that transdermal repaglinide delivery may have therapeutic promise, with benefits such as reduced dose frequency, better patient compliance, non-invasive properties, enhanced bioavailability, and ease of medication discontinuation.
Parisa Yousefee Baghbadoranee, H N K Al-Salman, Manish Vyas, K. Venkateshwarlu, A. Mohammadi, Oksana Strus, Mansour Amraei, A.E. Dorofeev, Galina Eduardovna Brkich, Behzad Fouladi Dehaghi, et al.
Published: 1 July 2019
ASIAN JOURNAL OF PHARMACEUTICS, Volume 13; https://doi.org/10.22377/ajppmds

Abstract:
Aim: A semisolid (avaleha) herbal formulation Drakshavaleha (DKV) was prepared based on the method described in Ayurvedic Formulary of India. It contains Vitis vinifera (Draksha), Piper longum (Pippali), Glycyrrhiza glabra (Yeshtimadhu), Zingiber officinale (Sunthi), Bambusa arundinacea (Vamshalochana), Emblica officinalis (Dhatri Phala or Amalaki), and honey and sugar (Sarkara). Materials and Methods: Methanolic extract of the DKV formulations was used for this study. Methanolic extract of three marketed preparation of DKV also use for the comparative study of DKV. This formulation was known as DKV-1, DKV-2, and DKV-3. A sample of this marketed formulation also used for 2, 2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity. Result and Discussion: The methanolic extract of DKV exhibited a maximum DPPH scavenging activity of 68.24% at 100 μg/ml, and marketed formulations of DKV (DKV-1, DKV-2, and DKV-3) exhibited maximum DPPH scavenging activity 67.90%, 68.35%, and 68.40%, respectively, at 100 μg/ml. With the standard ascorbic acid, it was found to be 84.75% at 100 μg/ml. The IC50 values of the methanolic extract of DKV were 63.27 μg/ml, and marketed formulations (DKV-1, DKV-2, and DKV-3) were 63.13 μg/ml, 62.82 μg/ml, and 62.91 μg/ml, respectively, and ascorbic acid was 40.05 μg/ml. Conclusion: Results obtained suggest the antioxidant and free radical scavenging activity potential of DKV, and further it may be used as an antioxidant in associated diseases.
Narendra Yadav, MangalSingh Panwar
Published: 1 January 2015
ASIAN JOURNAL OF PHARMACEUTICS, Volume 9; https://doi.org/10.4103/0973-8398.160311

Abstract:
Terbutaline sulphate is a selective B2 bronchodilator which is used in the treatment of asthma. Conventional Terbutaline tablets available in the market are not suitable where quick onset of action is required. Terbutaline sulphate sublingual tablets were prepared by using mannitol, microcrystalline cellulose pH102 (F1) and lactose monohydrate, microcrystalline cellulose pH102 (F4) as filler and its combination in different ratio, Crospovidone as superdisintegrant and sodium lauryl Sulphate as permeability enhancers by drug dispersion direct compression method.The formulation F1 found the 93.51% of % drug permeability, 8 seconds disintegration time and 96.95% drug release within one minute. The formulation F4 also found the 98.25% of drug permeability, 13 seconds disintegration time and 90.31% drug release within one minute. It was concluded that the sublingual tablet of Terbutaline sulphate can be formulated for sublingual absorption of drug in emergency treatment of asthma by Mannitol and Microcrystalline cellulose pH 102 in combination (75% and 25% respectively) or lactose monohydrate and Microcrystalline cellulose pH 102 in combination (75% and 25% respectively) as filler, Crospovidone as superdisintegrant, and Sodium Lauryl sulphate as permeability enhancer by direct compression drug dispersion method
Gholamreza Dehghan-Noudeh, , Mandana Ohadi, Mohammad Zaman-Basir, Emad Yazdanpanah, Shirin Yusefian, Fariba Sharififar
Published: 1 January 2015
ASIAN JOURNAL OF PHARMACEUTICS, Volume 9; https://doi.org/10.4103/0973-8398.160316

Ss Shah, Dy Gohil, Dn Pandya, Db Meshram
Published: 1 January 2015
ASIAN JOURNAL OF PHARMACEUTICS, Volume 9; https://doi.org/10.4103/0973-8398.160314

Abstract:
The purpose of present research work was to develop spray-dried mucoadhesive microspheres of prochlorperazine (PCPZ) for intranasal administration with an aim to avoid first-pass metabolism and to improve therapeutic effectiveness. A 2 3 factorial design was employed with amount of polymer, feed flow rate and volume of gluteraldehyde as independent variables while particle size of the microspheres and percentage drug entrapment efficiency as dependent variables. The microspheres were evaluated for drug loading, surface morphology, degree of swelling, in-vitro mucoadhesion, drug release, histopathology and stability studies. Particle size of all batches was found to be in the range of 7.32-15.67 μm. The percentage entrapment efficiency was found to be in the range between 84.90 and 96.21. In-vitro mucoadhesion was performed by adhesion number using goat nasal mucosa and was observed in a range from 76.25 to 87.72. The optimum formulation was selected based on the criteria of attaining the minimum value of particle size with substantial entrapment efficiency. Scanning electron microscopy analysis of the microspheres revealed that the microspheres were nearly smooth and spherical. In-vitro diffusion studies showed non-Fickian drug release. The Fourier transform infrared spectrophotometer spectra revealed no interaction between drug and excipients. Optimum formulation was found to be nonirritant in histopathology study carried out on goat nasal mucosa. The prepared microspheres were found to be stable over a period of 3 months even after stored at 40°C. In conclusion, PCPZ loaded mucoadhesive chitosan microspheres were reported for the first time, being suitable for intranasal delivery for the treatment of nausea and vomiting
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