Experimental & Clinical Medicine Georgia

Journal Information
ISSN / EISSN: 15120392 / 26679736
Total articles ≅ 235

Latest articles in this journal

Helen Phagava, Mariam Bakuradze, Mariam Mateshvili, Nino Grigolia, Karaman Pagava, Irakli Mchedlishvili
Experimental & Clinical Medicine Georgia; https://doi.org/10.52340/jecm.2022.08.03

Introduction. The tobacco epidemic is one of the biggest public health threats the world has ever faced, killing more than 8 million people a year around the world. The young people are the easiest target for the risky behavior. Aim. To assess knowledge, attitude and practice (KAP) regarding tobacco smoking among medical students in Georgia. Materials and Methods. KAP questionnaire containing 44 questions was developed in Georgian. Sampling frame consisted of students of the1st and 4th year of the Tbilisi State Medical University (TSMU) – Faculty of Medicine, Faculty of Public Health Management and Faculty of Public Health. Random cluster sampling was used and total number of participants was 242: 1st year students 39.51% (96), 4th year students 60.08% (146); Faculty of Medicine 62.96% (153), Faculty of Public Health 36.63% (89); female 183 (75.31%), male 59 (24.48%). Mean age was 20.63 (SD=2.2). Cross-sectional study was performed. The survey was anonymous and self-administered. Principles of Declaration of Helsinki were followed. Data analysis was done in Stata 14.0. Results. Based on the knowledge component, most students do not have complete information about tobacco products and the diseases they cause. Statistically higher number of the students of the Medical Faculty and male students had correct information about the harm of tobacco. 20.6% of respondents smoke, male 33.9%, female 16.4%. The main reason for starting smoking was cited as interest and the influence of friends. 32.1% of respondents stopped smoking after the quitting attempt. The maximum length of time to smoking after quitting was 7.9 months on average (SD = 7.8). Conclusion. Obtained results are mainly in line with the international findings. There was seen a statistically significant difference between public health and medical faculties and male and female in responses on knowledge and attitude. Taking into account that we have studied medical students it is less probable that the students of other specializations will be more knowledgeable in this regard. It is advisable to increase awareness activities in this regard.
Tinatin Kutubidze, Eka Nakhutsrishvili, Nineli Chkhaidze
Experimental & Clinical Medicine Georgia; https://doi.org/10.52340/jecm.2022.08.13

Herein we are presenting unusual case of severe neutropenia and JIA in a child. To our understanding, in this particular case, maternal Covid-19 caused an unusual presentation of neutropenia and JIA, with very high ANF. The role of neutrophils in pediatric rheumatology is an understudied field but is receiving increasing attention. Although clearly implicated in JIA, the specific contribution of neutrophils to pathogenesis and the use of neutrophil activity as biomarkers require further study.
Niko Papiashvili, Aliosha Bakuridze, Nikoloz Gongadze, Lasha Bakuridze, Mariana Landin Perez
Experimental & Clinical Medicine Georgia; https://doi.org/10.52340/jecm.2022.08.11

Arterial hypertension is the most common chronic disorder in economically developed countries leading to chronic disability and lethal outcome. During the recent years the attention of the researchers was focused on identifying new endogenous substances involved in vasoconstriction and vasodilation mechanisms. In this direction special attention is paid to vasodilating products of epoxygenic metabolism such as epoxyeicosatrienoic acids (EETs), whose rapid conversion in the body into less active metabolites such as dihydroxyeicosatrienoic acids (DHETs) is promoted by enzymatic epoxide hydrolase (sHE). According literature sources biologically active substance of plant origin – apigenin has the ability to inhibit sEH action, promoting the prolongation of EETs vasodilating activity. In the treatment of arterial hypertension, special attention is paid to the ability of the patient to use the drug independently, without any additional materials (water, syringe, etc.) and rapid action. Based on pharmacological studies plant origin phenolic compound sEH inhibitor-Apigenin by enhancing EETs vasodilatory activity provide beneficial effect on hemodynamic parameters and baroreflex sensitivity in hypertensive state being promising agent for improvement of different cardiovascular disorders. Based on artificial intelligence and biopharmaceutical studies, the formulation of apigenin orodispersible tablets and its technology was developed by sublimation method. As it was shown ODT of apigenin meet standard requirements in terms of quality. The use of sodium starch glycolate as disintegrant ensures the accelerated absorption of water into the tablets, which reduces the binding force between the particles and causes the tablets disintegration.
Mariam Matchavariani, Irine Zarnadzde, Shalva Zarnadze, Lili Lomtadze, Dali Kitovani, Marina Kajrishvili, Gulnara Abashidze, Giorgi Matchavariani
Experimental & Clinical Medicine Georgia; https://doi.org/10.52340/jecm.2022.08.18

The population, mostly those who are not employed, often turn to local self-government and governance, as with personal problems such as: one-off assistance, social assistance, property registration, plot registration, as well as environmental problems, e.g. caused by hull damage, caused by water supply. Also, with health problems (additional studies, operative intervention, post-operative studies, medications). As a result of the research, we concluded that it is necessary to increase the number of service places as well as increase funding. Based on the observation, we can say that the population is insufficiently aware of insurance, it is necessary to familiarize them with both services and financing programs, also getting to know their insurance program and their services in detail, which will be used later for the benefit of their health.
Ketevan Shalashvili, Tamar Sagareishvili, Marina Sutiashvili, Jemal Aneli, Meri Alania
Experimental & Clinical Medicine Georgia; https://doi.org/10.52340/jecm.2022.08.15

Preliminary studies on the content of flavonoids and triterpenoids were conducted of 27 families, of 66 genera, on 90 samples of 70 species of plants spread and cultivated in Georgia. 29 species have been investigated for the first time. Promising plants have been identified. Some of them are devoted to deep phytochemical studies. From the analyzed objects, the following families are distinguished by their flavonoid content: Ericaceae, Labiatae, Leguminosae, Malvaceae, Polygonaceae, Rosaceae, Scrophulariaceae, Tiliaceae, Umbelliferae, Verbenaceae; And in terms of triterpenoids, families are of particular interest: Apocynaceae, Capparaceae, Caprifoliaceae, Caryophyllaceae, Compositae, Ericaceae, Labiatae, Leguminosae, Oleaceae, Rosaceae, Scrophulariaceae, Thymelaeaceae, Umbelliferae. A flavonoid identified as quercetin-3-O-α-L-rhamnopyranosyl-(1®6)-β-D-glucopyranoside - rutin is obtained from the leaves of Capparis spinosa L.
Natalia Catherine Hargreaves, Ramaz Khetsuriani, Manana Arabuli-Tchlikadze, Anzor Gogiberidze, Nodar Mitagvaria
Experimental & Clinical Medicine Georgia; https://doi.org/10.52340/jecm.2022.08.12

We studied changes in the ultrastructure of synapses and myelin nerve fibers that develop in the penumbra in 4 and 12 hours after modeling infarction in the frontoparietal cortex in rats. Ischemic stroke was induced by injection of a photosensitive dye into their bloodstream followed by illumination of the brain surface with a halogen lamp. Visible ultrastructural changes were observed in the penumbra zone, namely in the axodendritic and axospinous synapses; they consisted in polymorphism and disorganization of synaptic vesicles, mitochondrial swelling, swelling and vacuolization of the postsynaptic fragments of dendrites, and shortening and osmiophilia of the active zone. In the presynaptic terminals, clear-cut signs of transformation were not observed during the first 12 hours. It indicates the necessity of early treatment of strokes.
Alexander Tarkhnishvili, Marina Nikolaishvili
Experimental & Clinical Medicine Georgia; https://doi.org/10.52340/jecm.2022.08.21

The data obtained indicate that the impact of ultrasound on rats during their stay in the womb causes the development of anxiety and depression, which is clearly seen as a result of our observations. The decrease in anxiety is due not only to residual effects of organic changes in brain structures associated with the organization of behavior, in particular, specific glutamatergic neurons, the "attack center" of the hypothalamus, but also to the activation of the entire adaptive-compensatory system, which is carried out as a result of prolonged ultrasonic exposure. It is seen from the behavioral components we conducted, namely, from the results obtained in the "open field". The clarification of these issues will deepen the current understanding of the effects of prolonged 20-30 min ultrasound exposure in rats in utero, and future studies of animal nervous system dysfunction.
Parvana Nizami Bagirova
Experimental & Clinical Medicine Georgia; https://doi.org/10.52340/jecm.2022.08.04

The purpose of the study was to study the clinical and anamnestic characteristics of women with specific vaginitis in different age groups from different angles. Materials and research methods. The research was carried out at the Research Institute of Obstetrics and Gynecology. The study included 120 women of reproductive age who were diagnosed with nonspecific vaginitis. Examination of women was carried out according to the generally accepted scheme: anamnesis, including complaints of patients, general clinical and gynecological examinations, laboratory, instrumental, bacteriological studies, the calculation was carried out by a mathematical method. The largest part of all patients was aged 18-30 years, i.e. reproductive age. Results and its discussion. The frequency of menstrual irregularities in women included in the study with nonspecific vaginitis was high. When studying pregnancy-related indicators in women with nonspecific vaginitis, it was found that the frequency of primary and secondary infertility, as well as miscarriage in these women, is quite high. The structure of extragenital diseases in women with nonspecific vaginitis was different. Although various pathologies (of the urinary system, respiratory organs, gastrointestinal tract, nervous system) occurred with different frequencies, the rates were quite high.
Tinatin Kutubidze, Nineli Chkhaidze, Eka Nakhutsrishvili
Experimental & Clinical Medicine Georgia; https://doi.org/10.52340/jecm.2022.08.02

A rare case of SCFN was diagnosed in a newborn, a rare disease in the neonatal period, emphasizes the importance of a histological findings for a definitive diagnosis. Subcutaneous fat necrosis of the newborn (SCFN) is an uncommon panniculitis of neonates. Although SCFN is a self-limited condition, recognition of this entity is important, as affected infants require monitoring for associated hypercalcemia or other complications. SCFN generally has a good outcome, with spontaneous resolution of skin lesions over weeks to months. However, death from hypercalcemia has been reported in a few infants with SCFN.
Zurab Dzidzava, Manana Giorgobiani, Erekle Mosidze
Experimental & Clinical Medicine Georgia; https://doi.org/10.52340/jecm.2022.08.09

The objective of all submissions is to study patients with esophageal atresia, discuss and evaluate their long-term outcomes, which can be achieved in an open space, and the preference of patients with esophageal atresia for operative management and rehabilitation. Observing visitors, about their peers, patients with a diagnosis of esophageal atresia do not have developmental delays compared to others. 32 patients aged 1 to 8 years who underwent surgery for esophageal atresia between 2013 and 2021 were studied.
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