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Journal Molecular & Cellular Proteomics

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3,732 articles
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Carolina Moller, William Clay Davis, Evan Clark, Anthony De Caprio, Frank Mari
Molecular & Cellular Proteomics; doi:10.1074/mcp.ra118.000972

The publisher has not yet granted permission to display this abstract.
Lila M. Gierasch, Nicholas O. Davidson, Kerry-Anne Rye, Alma L. Burlingame
Molecular & Cellular Proteomics; doi:10.1074/mcp.e119.001384

Georgina D Barnabas, Keren Bahar-Shany, Stav Sapoznik, Limor Helpman, Yfat Kadan, Mario Beiner, Omer Weitzner, Nissim Arbib, Jacob Korach, Tamar Perri, et al.
Molecular & Cellular Proteomics; doi:10.1074/mcp.ra119.001362

Abstract:High-grade ovarian cancer (HGOC) is the leading cause of mortality from gynecological malignancies, due to diagnosis at a metastatic stage. Current screening options fail to improve mortality due to the absence of early-stage-specific biomarkers. We postulated that a liquid biopsy, such as utero-tubal lavage (UtL), may identify localized lesions better than systemic approaches of serum/plasma analysis. Furthermore, while mutation-based assays are challenged by the rarity of tumor DNA within non-mutated DNA, analyzing the proteomic profile, is expected to enable earlier detection, as it reveals perturbations in both the tumor as well as in its microenvironment. To attain deep proteomic coverage and overcome the high dynamic range of this body fluid, we applied our method for microvesicle proteomics to the UtL samples. Liquid biopsies from HGOC patients (n=49) and controls (n=127) were divided into a discovery and validation sets. Data-dependent analysis of the samples on the Q-Exactive mass spectrometer provided depth of 8,578 UtL proteins in total, and on average ~3,000 proteins per sample. We used support vector machine algorithms for sample classification, and crossed three feature-selection algorithms, to construct and validate a 9-protein classifier with 70% sensitivity and 76.2% specificity. The signature correctly identified all Stage I lesions. These results demonstrate the potential power of microvesicle-based proteomic biomarkers for early cancer diagnosis.
Timothy L. Karr, Helen Southern, Matthew A. Rosenow, Toni I. Gossmann, Rhonda R. Snook
Molecular & Cellular Proteomics; doi:10.1074/mcp.ra118.001098

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Christoph Wichmann, Florian Meier, Sebastian Virreira Winter, Andreas-David Brunner, Jürgen Cox, Matthias Mann
Molecular & Cellular Proteomics; doi:10.1074/mcp.tir118.001131

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Clinton Yu, Xiaorong Wang, Alexander S Huszagh, Rosa Viner, Eric J Novitsky, Scott D. Rychnovsky, Lan Huang
Molecular & Cellular Proteomics; doi:10.1074/mcp.tir119.001323

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Anthony Siau, Ximei Huang, Han Ping Loh, Neng Zhang, Wei Meng, Siu Kwan Sze, Laurent Renia, Peter R. Preiser
Molecular & Cellular Proteomics; doi:10.1074/mcp.ra118.000997

Abstract:Efforts to develop vaccines against malaria represent a major research target. The observations that 1) sterile protection can be obtained when the host is exposed to live parasites and 2) the immunity against blood stage parasite is principally mediated by protective antibodies suggest that a protective vaccine is feasible. However, only a small number of proteins have been investigated so far and most of the Plasmodium proteome has yet to be explored. To date, only few immunodominant antigens have emerged for testing in clinical trials but no formulation has led to substantial protection in humans. The nature of parasite molecules associated with protection remains elusive. Here, immunomic screening of mice immune sera with different protection efficiencies against the whole parasite proteome allowed us to identify a large repertoire of antigens validated by screening a library expressing antigens. The calculation of weighted scores reflecting the likelihood of protection of each antigen using five predictive criteria derived from immunomic and proteomic datasets, highlighted a priority list of protective antigens. Altogether, the approach sheds light on conserved antigens across Plasmodium that are amenable to targeting by the host immune system upon merozoite invasion and blood stage development. Most of these antigens have preliminary protection data but have not been widely considered as candidate for vaccine trials, opening new perspectives that overcome the limited choice of immunodominant, poorly protective vaccines currently being the focus of malaria vaccine researches.
John D. Lapek, Zhenze Jiang, Jacob M. Wozniak, Elena Arutyunova, Steven C Wang, M. Joanne Lemieux, David J. Gonzalez, Anthony J. O'donoghue
Molecular & Cellular Proteomics; doi:10.1074/mcp.tir118.001099

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Shubham Gupta, Sara Ahadi, Wenyu Zhou, Hannes Rost
Molecular & Cellular Proteomics; doi:10.1074/mcp.tir118.001132

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Lakmali Munasinghage Silva, Thomas Kryza, Thomas Stoll, Christine Hoogland, Ying Dong, Carson R. Stephens, Marcus L. Hastie, Viktor Magdolen, Oded Kleifeld, Jeffrey J. Gorman, et al.
Molecular & Cellular Proteomics; doi:10.1074/mcp.ra118.001304

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