Science and Technology Development Journal - Natural Sciences

Journal Information
ISSN / EISSN : 2588106X / 2588106X
Current Publisher: Viet Nam National University Ho Chi Minh City (10.32508)
Former Publisher: Biomedical Research and Therapy (10.15419)
Total articles ≅ 328
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Latest articles in this journal

Linh Chi Thi Tran, Hai Quang Ha
Science and Technology Development Journal - Natural Sciences, Volume 4; doi:10.32508/stdjns.v4i3.608

Abstract:
By 5 main methods including data collections and compilations, field surveys, similarity comparison, mapping and GIS, the geomorphological characteristic of notches in Ha Tien – Kien Luong containing morphologies, origins and ages are proved. Those notches had morphologies of U and V and 3 types of origins including chemical solution, mechanical abrasion and bioerosion; notches were formed in stage of Holocene regressive sea. Notches were created at four stopped periods corresponding to four sea level elevations: 5 m, 3 m, 1 m and 0 m (current sea level) respectively had the age of 5.480, 3.180, 1.025 years ago and the current level has being formed. This research had provided a useful scientific literature that includes the essential role of organisms in forming notches, the influences of organisms, waves and shielding rate on morphologies, and evidence of climate change in the past. By those reasons, people need to calm down, observe, adapt, and respond flexibly to the climate change instead of constructing costly structures. Coastal notches are important marine geological heritage so the conservation of those coastal notches were necessary for research and education, prediction of the sensitive Ha Tien – Kien Luong region, contribution towards risks of planning and construction in areas of underground limestone caves.
Phuong Thi Bach Vu, Dai Minh Cao, Phuong Ngo Diem Quach
Science and Technology Development Journal - Natural Sciences, Volume 4; doi:10.32508/stdjns.v4i3.902

Abstract:
Recent studies have demonstrated the potential of in vitro Urena lobata L. hairy roots to inhibit α-glucosidase for supporting the treatment of type 2 diabetes. To increase the productivities of hairy roots with α-glucosidase inhibitory activity in in vitro culture conditions, this study focus on the effects of some metabolic factors such as precursors (L-phenylalanine, L-tyrosine) and elicitors (chitosan, methyl jasmonate, salicylic acid). They were added to the culture media to investigate the growth and α-glucosidase inhibitory activity of Urena lobata L. hairy roots. The results showed that for the effects of precursors, only phenylalanine (1 µM) increased root biomass with the highest of α-glucosidase inhibitory activity on the 25th day of culture. In contrast, tyrosine did not play any role in increasing the biomass and α-glucosidase inhibitory activity in Urena lobata L. hairy roots. For the effects of elicitors, only chitosan (50 mg/L) resulted in hairy roots with α-glucosidase inhibitory activity higher than the control after 3 days in culture medium. Other elicitors such as methyl jasmonate, salicylic acid had lower α-glucosidase inhibitory activity than the control. The results of this study demonstrated the potential of phenylalanine and chitosan in increasing the productivity of in vitro hairy roots with higher α-glucosidase inhibitory activity in Urena lobata L.
Nguyễn Tuấn, Trần Văn Xuân, Trần Văn Trị, Phan Vương Trung, Đỗ Quang Khánh, Trương Quốc Thanh, Nguyễn Xuân Khá, Phạm Việt Âu
Science and Technology Development Journal - Natural Sciences, Volume 4; doi:10.32508/stdjns.v4i3.895

Abstract:
Dòng dầu khí thương mại được phát hiện tại tập cát kết 5.2U, mỏ Rồng Trắng lô 16-1 trầm tích Miocen hạ bể Cửu Long. Tuy nhiên tầng chứa thường là tập hợp các vỉa mỏng, bất đồng nhất. Trên cơ sở xác định nguồn gốc của vật liệu, điều kiện biến đổi của môi trường, chế độ động lực của quá trình vận chuyển, bối cảnh địa hóa môi trường lắng đọng và tạo đá, công trình làm sáng tỏ quy luật phân bố tướng đá tầng chứa. Việc áp dụng phương thức tiếp cận tổng hợp địa chấn, tài liệu thạch học, mẫu lõi và địa vật lý giếng khoan kết hợp với ứng dụng mô hình địa chất phân giải cao cho phép chính xác hoá quy luật phân bố tướng đá của tập ILBH 5.2. Kết quả nghiên cứu tập đã phân loại thành công tướng đá chủ yếu ứng với môi trường thành tạo: Môi trường sông gồm tướng tướng trầm tích lòng sông, trầm tích vỡ đê và trầm tích ven sông phân bố theo phương từ Tây – Đông đến Bắc Tây Bắc – Nam Đông Nam, trong đó vùng Bắc – Tây Bắc đá chứa có chất lượng tốt nhất, theo phương Đông Nam là các tướng trầm tích lòng hồ, trầm tích cát ven bờ và trầm tích cát xa bờ được hình thành trong môi trường hồ và tại ranh giới giữa 2 môi trường đá chứa có chất lượng cao hơn cả. Cơ chế hình thành thành hệ trầm tích chứa dầu khí tuổi Miocen của lô 16-1 nói riêng, khu vực Trung Bộ phức tạp, để có thể dự đoán xu thế phân bố tiềm năng của thành hệ này, cần tiến hành đánh giá vai trò của phức hệ macma trong quá trình thành tạo thành hệ chứa dầu khí tuổi Miocen.
Công-Thắng Dương, Xuan Thi Thi Luu
Science and Technology Development Journal - Natural Sciences, Volume 4; doi:10.32508/stdjns.v4i3.868

Abstract:
Multi-component reactions (MCRs) played an important role to produce complex molecular structures in a one-step process. Among all MCRs reported, Biginelli reaction was one of the most well-known and used in organic synthesis to constitute pyrimidine scaffolds. Therefore, a solvent-free Biginelli reaction of 2-aminothiazole, benzaldehyde and ethyl acetoacetate catalyzed by Amberlyst-15 (A-15) had attracted us to pay attention and to do research in order to highly obtain a desired product, a frame of thiazolo[3,2-a]pyrimidine being present in many active biological compounds. Amberlyst-15, polystyrene resin regarded as a green acidic solid, available commercial, inexpensive and reusable catalyst had been firstly and successfully developed for solvent-free Biginelli reaction under ultrasound irradiation to form thiazolo[3,2-a]pyrimidine. Most factors which had influenced on the reaction conversion and yield such as the molar ratios between 2-aminothiazole, benzaldehyde and ethyl acetoacetate, the amounts of catalyst A-15, and reaction time had been investigated. Consequently, the yield of ethyl 7-methyl-5-phenyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate had been also found to depend on the amount of the acidic solid catalyst and little excess amounts of the two reactants, e.g. 2-aminothiazole and ethyl acetoacetate. The maximum yield has been obtained 76% after six-hour ultrasound irradiation at 80oC with the molar ratio of 2-aminothiazole : benzaldehyde : ethyl acetoacetate (1.4:1.0:1.4) and 50 mg of catalyst A-15. The results showed that Amberlyst-15 had high capability of recovery and recycling owing to the inconsiderably changes of product yields after two recycle runs.
Le Thi Xuan Thuy, Le Thi Suong
Science and Technology Development Journal - Natural Sciences, Volume 4; doi:10.32508/stdjns.v4i3.937

Abstract:
This article presented the results of color treament ability of Tarcon Blue 2BLN dye with some flocculation chemicals such as PGa21Ca, polyaluminium chloride (PAC), iron (II) sulfate heptahydrate (FeSO4.7H2O) and aluminium sulfate octadecahydrate (Al2(SO4)3.18H2O). Our results showed that conditions for treatment the color to reach column B, QCVN 13: 2015 / BTNMT (national technical regulation on textile and dying industry) by different flocculation chemicals were the same exposure time (10 minutes), sedimentation time (30 minutes), but different in parameters of concentration (% mass), stirring speed and pH. Specifically: PGa21Ca (0.02%), PAC (0.01%), aluminium sulfate octadecahydrate (0.003%) can handle color at the initial pH of the solution (pH = 6), with the stirring speed corresponding to each flocculation chemical at 120 rpm, 45 rpm and 45 rpm respectively. In contrast, with iron (II) sulfate heptahydrate (0.02%), only the color treatment reaches column B, QCVN 13: 2015 / BTNMT when the pH of the wastewater raises to 10 and stirring speed is 120 rpm. Compared with PAC, aluminium sulfate octadecahydrate and iron (II) sulfate heptahydrate, PGa21Ca has the advantage of contributing to raise the pH value in the acid solution, which reduces the pH in the base environment, and not changing the pH when the concentration of PGa21Ca increases. Test results on actual wastewater samples taken from Hoa Khanh Danang Textile Joint Stock Company (DANATEX) showed that the ability of treating color of these chemicals on actual wastewater samples is lower than the ability on water samples blended with Tarcon Blue 2BLN dye.
Đái Thị Xuân Trang, Hieu Le Trung Bui, Linh Chi Tran, Danh Thai Luu, Tuan Trong Nguyen
Science and Technology Development Journal - Natural Sciences, Volume 4; doi:10.32508/stdjns.v4i3.880

Abstract:
Miliusa velutina (MV) stem bark has various medicinal uses, but its hepatoprotective effect has not yet been studied. This study investigated the antioxidant and hepatoprotective activity of the ethanol extract of MV stem bark against carbon tetrachloride (CCl4)-induced liver injury. The ethanol extract of MV stem bark was evaluated for in vitro antioxidant activity which exhibited good antioxidant activity in terms of ferric reducing-antioxidant power assay (EC50, FRAP=4.04±0.00 µg/mL), total antioxidant capacity assay (EC50, TAC=8.73±1.08 µg/mL) and 1,1-diphenyl-2-picrylhydrazyl (EC50, DPPH=9.33±0.07 µg/mL) radical scavenging assay. Mice were pretreated with CCl4 (2.5 mL/kg body wight per day) in 4 consecutive weeks. After one hour taking CCl4 by oral administration, mice were treated with the ethanol stem bark extract of MV at various concentrations of 100, 200, and 400 mg/kg body weight. The MV stem bark at the dose of 400 mg/kg body weight effectively reduced the level of alanine transaminase (38±6.78 U/L) and aspartate transaminase (AST) in serum. Besides, the MV stem bark at the dose 400 mg/kg body weight reduced the malondialdehyde (3.12±1,19 nM MDA/g tissue) level, and increased the activity of reduced glutathione (896.21±22.69 nM GSH/g tissue) in liver. The observation of the microscopic cross section of liver tissue also revealed that the mice treated with stem bark extract of MV at the dose of 200 and 400 mg/kg body weight had significantly improvement in liver tissues compared to the non-treated control group. Histological analyses of the MV-treated group exhibited reducing inflammatory process and preventing liver necrosis and fibrosis. In summary, the hepatoprotective effect of MV stem bark was seemingly associated with its antioxidant activity.
Khoa Le Dang, Thanh Hai Ngo, Nghia Thai Cong Nguyen
Science and Technology Development Journal - Natural Sciences, Volume 4; doi:10.32508/stdjns.v4i3.662

Abstract:
Non-orthogonal multiple access (NOMA) is one of the potential technologies for fifth generation (5G) cellular networks. This technique can combine with other techniques such as Orthogonal Frequency Division Multiplexing (OFDM) and Multiple Input Multiple Output (MIMO). In NOMA downlink, signals from multiple users are superposed in time-frequency domain. Hence, NOMA systems have a larger throughput than orthogonal multiple access systems. There are several schemes for NOMA detection. The successive interference cancellation (SIC) is commonly used to decode desired signals at the receivers. Some NOMA schemes with SIC are ideal SIC, symbol-level SIC and codeword-level SIC. The previous studies showed that the log-likelihood ratio (LLR) has a performance as ideal SIC. In this paper, we derive the bit error rate for a NOMA downlink system with 2 users (UE) using LLR receiver. This study considers the system over a Rayleigh fading channel and the presence of Additive White Gaussian Noise. The closed-form equations have been proposed for each user with QPSK mapping. The simulation results show that the performance of the system is consistent with the proposed formula
The Thai Nguyen, Phuong Hoang Tran
Science and Technology Development Journal - Natural Sciences, Volume 4; doi:10.32508/stdjns.v4i3.901

Abstract:
Magnetic nanoparticle supported deep eutectic solvents have been synthesized by preparing and grafting [Urea]4[ZnCl2] deep eutectic solvent onto the surface of silica-coated Fe3O4 magnetic nanoparticles using 3‐ chloropropyltrimethoxysilane as a linker. [email protected] was fully characterized using scanning and transmission electron microscopies, Fourier transforms infrared, energy-dispersive X-ray spectroscopies, vibrating sample magnetometer X-ray diffraction, and thermogravimetric analysis. In this study, we have developed the synthesis of 2-benzylbenzoxazole via condensation reaction of 2-nitrophenols and acetophenones using a magnetic nanoparticle supported [Urea]4[ZnCl2] deep eutectic solvent as a novel, green and efficient catalyst. In the presence of 1,4-diazabicyclo[2.2.2]-octane, elemental sulfur acted as an excellent reductant in promoting oxidative rearranging coupling in this reaction. The reaction has been conducted via the stirring method and the reaction conditions were surveyed (16 h, 130 °C, acetophenone, 2-nitrophenol, DABCO and sulfur molar ratio of 2:1:1:3, 10 mol% [email protected] catalyst). Six 2-benzylbenzoxazole derivatives have been synthesized via this method with good yield (86-91%). The structure of the pure product has been confirmed through FT-IR, 1H NMR, 13C NMR, and GC-MS methods. More importantly, [email protected] has been separated from the reaction mixture by a magnet and reused over five consecutive runs without significant loss of catalytic activity.
Thư Anh Nguyễn Phạm, Trang Thị Thuỳ Nguyễn, Nghĩa Hiếu Nguyễn, Thao Thi Phuong Dang
Science and Technology Development Journal - Natural Sciences, Volume 4; doi:10.32508/stdjns.v4i3.900

Abstract:
Keratinocyte Growth Factor (KGF) is a paracrine-acting and epithelium-specific growth factor produced by cells of mesenchymal origin, play an important role in promoting proliferation, differentiation, motility of epithelial cells and stimulating regeneration of damaged epithelial tissues. Recent studies indicated that recombinant KGF is produced in many different expression systems such as bacteria, insect cells, plant and mammalian cells. However, KGF’s yields obtained from these systems is low and production’s cost is high especially in mammalian cells. In this study, the yeast Pichia pastoris was chosen as a host for KGF expression through induction of methanol by promoter AOX on pPICzαA vector system. The results demonstrated that the Pichia pastoris X33:kgf transformants secreted KGF directly into BMMY medium after inducing by 0.5% methanol. The recombinant protein was purified by heparin affinity chromatography with the yield of 1.35 mg/l and the purity of 99.89% showed by SDS-PAGE. In addition, MTT assay showed the purified recombinant KGF had a proliferation effect on A549 cell line since A549 known as a cell has KGF’s receptor.
Mai T. N. Huynh, Phuc H. T. Nguyen, Hieu H. C. Phan, Nghia T. H. Phan, Kong H. Le, Nhu T. H. Truong, Khanh Le, Dung V. Ho, Vy T. Nguyen, Ha L. B Tran, et al.
Science and Technology Development Journal - Natural Sciences, Volume 4; doi:10.32508/stdjns.v4i3.907

Abstract:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the confirmed viral pathogen of COVID-19, a pandemic originated from Wuhan, China at the end of 2019. Since then, SARS-CoV-2 has rapidly spread across the globe with over 8 million confirmed cases and more than 430.000 deaths worldwide as of mid-June 2020. Similar to other strains of coronavirus, the envelope of SARS-CoV-2 comprises of three structural proteins: S protein (spike), E protein (envelope) and M glycoprotein (membrane). SARS-CoV-2 capsids are spherical or pleomorphic. Each capsid contains a positive-sense single-stranded RNA (+ssRNA-Class IV-Baltimore) associated with nucleoprotein N. The viral RNA genome is approximately 30 kb in length and contains 14 open reading frames (ORFs). The binding affinity of the viral S protein to the ACE2 (angiotensin-converting enzyme 2) receptor facilitates the attachment of SARS-CoV-2 to human epithelial cells. Upon binding, SARS-CoV-2 spike protein is cleaved and activated by TMPRSS2 (transmembrane protease, serine 2) or by cathepsin L at the cleavage site S2', and also by furin at the cleavage site S1/S2. The furin cleavage motif RR_R is a notable feature, firstly found in SARS-CoV-2 S protein, which may increase virus transmission rate. This feature and many others might result from several evolution events in SARS-CoV-2 genome. These events could occur when coronaviruses, including SARS-CoV-2, spread from one host to another. They can be causative to high virulence and transmission rate of future coronavirus strains, which may require the development of newer vaccine generations. To understand of SARS-CoV-2’s structure, infection mechanism, diagnosis, treatment, and vaccine development strategies, a review of current literature is of highly importance to disease control in Vietnam.
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