Carbohydrate Polymers

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ISSN / EISSN : 0144-8617 / 1879-1344
Published by: Elsevier BV (10.1016)
Total articles ≅ 19,299
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Araceli Martín-Illana, Eva Chinarro, Raul Cazorla-Luna, Fernando Notario-Perez, M.D. Veiga-Ochoa, Juan Rubio,
Published: 2 December 2021
Abstract:
Karaya gum, pectin and xanthan gum have been tested as candidates for manufacturing mucoadhesive trilayer films containing ethylcellulose and chitosan for the vaginal administration of the antiviral Tenofovir (TFV). The swelling profile correlated with the amount of mobile dipoles determined by impedance spectroscopy allows the determination of the hydration dynamics of these films. The fast water penetration has been demonstrated to favor the formation of polyelectrolyte complexes (PEC) via hydrogen or ionic bonds which would favor a controlled release. The incorporation of an inorganic drug release regulator induces the weakness of the polymeric chains thus enhancing the ionic mobility via the formation of low molecular weight PECs in films manufactured with karaya gum. Due to the different mechanical properties of the individual components, pectin-based films failed for a potential pharmaceutical formulation. However, mucoadhesive trilayer films produced with xanthan gum have demonstrated a moderate swelling, improved wettability and a controlled release of TFV.
Lei Wang, Xiaodong Liu, Peng Qi, Jun Sun, Shengling Jiang, Hongfei Li, ,
Published: 2 December 2021
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Nan-Nan Zhang, He Ma, Zhong-Fei Zhang, Wen-Na Zhang, Lei Chen, Wen-Juan Pan, Qing-Xi Wu, ,
Published: 2 December 2021
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Huimei Wang, Ying Li, Xuelian Wang, Yuhao Li, Jianlin Cui, Da-Qing Jin, Muhetaer Tuerhong, Munira Abudukeremu, ,
Published: 30 November 2021
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I-Ming Lee, Tzu-Yin Huang, Feng-Ling Yang, Victor Johansson, Chun-Ru Hsu, Pei-Fang Hsieh, Shin-Tai Chen, Yen-Ju Yang, Peter Konradsson, Jyh-Horng Sheu, et al.
Published: 28 November 2021
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, Ning Tang, Xuchen Jin, Wenhua Gao
Published: 27 November 2021
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Mohammad Asad, Abdullah M. Asiri, Naved Azum, Susanna Monti,
Published: 27 November 2021
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