International Journal of Advanced Biological and Biomedical Research

Journal Information
ISSN / EISSN : 2383-2762 / 2322-4827
Published by: Sami Publishing Company (10.33945)
Total articles ≅ 108
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, Jude A. Odugu, Salihu Njidda, Blessing Ogechukwu Umeokoli, Abdulqadir Bukar Bababe, Mathias Simon Bingari, Alexander E. Angyu
International Journal of Advanced Biological and Biomedical Research, Volume 8, pp 321-339; https://doi.org/10.33945/sami/ijabbr.2020.4.1

Abstract:
Cancer disease has been on the increase recently in both developed and developing countries of the world resulting in 40 million deaths annually. Ethno-medicinal survey of indigenous herbal plants used in traditional medicine in the treatment of cancers was conducted in major communities in Bali, Gashaka and Sarduana Local Government Areas Taraba State Nigeria. Traditional medicine practitioners as well native herbalists, herbal plants and product marketers were orally interviewed by structured questionnaires. One hundred and six (106) species of plants from forty-nine (49) families were surveyed and documented in this study. Out of these, 70 % of the plants were neither screened for their anticancer activity nor documented in literatures while no any members of the Families Salvadoraceae, Simaroubaceae, and Elatinaceae have ever been reported for their anticancer activity. Members of the Family Fabaceae have the highest number of species distribution with 15%, followed by Family Asteraceae with 9% while Family Rubiaceae and Annonaceae have 6% and 5% distribution respectively. The leaves of the plants were the most used part in the treatment of cancers in all the communities, and preparation is usually by decoction. Sides effects of these plants were generally low on observation.The need for conservation of these plants is of utmost important because most these plants might go into extinct as a result of urbanization pressure and timber activities in most of these areas surveyed.
, Sabah Al-Rafat
International Journal of Advanced Biological and Biomedical Research, Volume 8, pp 369-381; https://doi.org/10.33945/sami/ijabbr.2020.4.4

Abstract:
As a novel performance, silicon oxide was firstly loaded on Fe3O4 magnetic nanoparticles substrate ([email protected]), and then functionalized with -NH2 group ([email protected]@NH2). The resultant array was reacted with terephthalaldehyde schiff-base to fabricate novel hierarchical magnetic nano-composites. A sensitive sensor involving immobilized gold nanoparticles and nano-composites in electropolymerized polypyrrole was achieved. Cyclic voltammetry (CV), scanning electron microscopy (SEM) and electrochemical impedance spectroscopy (EIS) techniques were demonstrated the morphology of modified electrode's surface and electrochemical behavior of thyroxine on this platform. We believe that such kind of bio-devices possesses the prominent potential to trace determination of bio-compounds in biological fluids with excellent accuracy and precise analysis. This sensor covered a linear concentration range from 10 to 210 nM of thyroxine with the detection limit of 8 nM.
, Ali Jafari, Reza Alimardani, Valiollah Mohammadi, James Grichar
International Journal of Advanced Biological and Biomedical Research, Volume 8, pp 339-357; https://doi.org/10.33945/sami/ijabbr.2020.4.2

Abstract:
Brasica napus L. is one of the most important crops in the world, but every year during mechanized harvesting with conventional combines large quantities of the seeds fall to the ground and thus result in a decrease in yield. Therefore, designing and manufacturing a head specific for harvesting this crop is a high priority. In this study, the head of a combine for harvesting fine-grained products were designed, manufactured and evaluated. Initially, different designs were modeled in Solidworks 2018 software and analyzed in Ansys workbench 2019 software. The best scheme was selected between different designs and a prototype was developed. The results of the analysis indicated that the fabricated apparatus has sufficient strength and stability. The results of field tests indicate that the generalization of the proposed scheme on the scale of a real combine harvester can help to decrease the grain loss for fine-grained products.
, Narjes Mohammadi Bandari
International Journal of Advanced Biological and Biomedical Research, Volume 8, pp 283-289; https://doi.org/10.33945/sami/ijabbr.2020.3.6

Abstract:
Background: The immune antigen of Bacillus anthracis is a protein that can attach to the surface receptor of all human cells. At the surface of cancer cells, there is a receptor that activates the uPA (Urokinase plasminogen) that do not exist in normal human cells. Objectives: The aim of this study was changing the location of the attachment of the PA gene by a directed mutation in order to attach only to the cancer cells.Methods: PA gene was extracted from the pMNA1 plasmid. The mutation on the PA gene was made by Overlap Extension PCR. The mutated segment was transferred to DH5α; the strain of Escherichia coli. With TA coning carrier. By restriction enzymes Hind III and BamH I the mutated PA gene was extracted and transferred to pWB980 and by electroporation method, it was transferred to the WB600 strain.Results: In this study, the mutation was occurred in sequences of PA gene by SOE PCR method resulting in a change in the genetic code of amino acid 194. The occurrence of mutation was confirmed by determining base sequences. Conclusion: Cancer is a severe disease that has a major impact on large groups of people which the problem of cancer is a leading cause of death across the world. One of the treatment methods of cancer is bacterial toxins if only cancer cells receive them. Therefore, these mutated PA proteins can be effective as novel therapeutic agents for the treatment of cancer.
, Mahboubeh Jahanshahi, Saeed Moghadam
International Journal of Advanced Biological and Biomedical Research, Volume 8, pp 302-313; https://doi.org/10.33945/sami/ijabbr.2020.3.8

Abstract:
The role of heart disease in increasing worldwide death and the limited availability of organs for transplantation have encouraged multiple strategies to fabricate functional and implantable constructs. One of these strategies is to develop a biologically similar heart tissue scaffold, in which two types of fiber and hydrogel are commonly used. Toward this goal, taking advantage of both hydrogels properties and fibers features with excellent mechanical properties can be considered as a promising method. The purpose of this study is to develop a fiber/hydrogel composite of gelatin, poly-caprolactone (PCL), cardiac extracellular matrix (ECM), and chitosan. The fibrous scaffolds of PCL and gelatin were characterized by SEM, water drop contact angle test, FTIR, and mechanical tests. The results showed that the average diameter of nanofibers, hydrophilicity and mechanical properties of the fibrous scaffolds increased with increasing the gelatin content in the spinning solution. Furthermore, the results of mechanical tests indicated that by integrating fibers with gelatin to PCL mass ratio of 2 in the hydrogel of chitosan and ECM with a mass ratio equal to 1, we obtained a construct with similar mechanical properties to native heart tissue, which may be proposed as an appropriate scaffold for heart tissue engineering.
International Journal of Advanced Biological and Biomedical Research, Volume 8, pp 314-320; https://doi.org/10.33945/sami/ijabbr.2020.3.9

Abstract:
One of our objectives in this investigation is to determine responses of S. littoralis through different developmental stages and generations to secondary metabolic compound presumably gossypol. Gossypol did not significantly show antifeedant except with high concentration (1.7% gossypol in the diet) that gave 10.6, 21.9, and 46.8% for three generations, respectively. Significantly longer larval life-spans were observed in S. littoralis on a high concentration of gossypol compared with those fed on low concentrations. The larval and pupal weight of the third generation was significantly lower than that of the previous two generations as latent effects on survived larvae significantly lower fecundity was found in the second and third generations. A significantly lower relative growth rate was observed in the three successive generations. Generally, the efficiency of gossypol was significantly higher in the second and third generations. Gossypol significantly affected growth and development, suggesting that diet-gossypol efficiency was different based on concentration and generation. This study will shed some light on the possibility of controlling S. littoralis by gossypol through the sequence of alternative spraying programs.
Hossein Karbalaei Khiavi, Davoud Hassanpanah
International Journal of Advanced Biological and Biomedical Research, Volume 8, pp 225-235; https://doi.org/10.33945/sami/ijabbr.2020.3.1

Abstract:
This study was performed in order to determine the distance of isolation for the seed potato production from ware potato in three regions of Ardabil, Namin and Nir. The experiment was carried out in a randomized complete block design (RCBD) with five distances (100, 200, 300, 400 and 500 meters from ware potato) and three replications with Super Elite (SE) class of Agria potato cultivar from ware potato as the source of infection studied by ELISA during 2014 and 2015. According to standard of Seed and Plant Certification and Registration Institute (SPCRI) number of 200 leaves and 200 tubers samples of each distance were collected and their virus in fection was by ELISA assay. Analysis of variance tuber yield showed that between regions, years and distances of isolation were significantly differences. In terms of tuber yield, between distances 500, 400 and 300 meters were not significantly difference and were in one group. With reducing of isolation distance from 500 meters to 100 meters from host of viral diseases vectors (edible potato of Agria cultivar) were decreased tuber yield from 44.328 ton per hectare to 39.828 ton per hectare (about 4.5 ton per hectare, or 10.15 percent). Average infection of Rhizoctonia fungal diseases of tuber in isolation distances and three regions were about 5 percent. In three regions and five isolation distances, tubers were without infection of vascular rot fungus diseases, without infection of bacterial diseases of blackleg and brown rot and without infection of potato moth pest.
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