Medical Journal of Viral Hepatitis

Journal Information
EISSN : 2314-8756
Current Publisher: Zagazig University Medical Journal (10.21608)
Total articles ≅ 30
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Elhammady Dina, Nasser Mousa, Eissa Sarah, Awad Mahmoud, Mohamed Islam, Eldars Waleed, Diasty Muhammad
Medical Journal of Viral Hepatitis pp 69-73; doi:10.21608/mjvh.2020.80655

Abstract:
Background and study aim. The introductionof directacting antiviral agents (DAAs) hasincreased sustained virologic response (SVR) rates inpatients with chronic hepatitis C infection (CHC). Theaim of this study is to evaluate the efficacy of DAAsin treatment of Egyptian patients with CHC, and todetermine the parameters associated with non-responseto DAAs Patients and methods. This study included200 treatment-naïve chronic hepatitis C patients whowere divided into two groups and treated accordingto the Egyptian National Treatment Program forHepatitis C Virus. Group 1 consisted of 100 easy-totreatpatients who were administered sofosbuvir 400mg daily/daclatasvir 60 mg daily for 3 months, whilegroup 2 included 100 difficult-to-treat patients treatedby Sofosbuvir 400 mg/ daclatasvir 60 mg /ribavirindaily for 3 months Results. The overall patient sustainedvirologic response (SVR) in the present studywas 93.5% (187/200). SVR in group 1 was 100%, whilegroup 2 showed SVR of 87% (87/100). Comparisonbetween patients with and without SVR revealed nostatistically significant differences regarding age andsex distribution, serum albumin, bilirubin, transaminaseslevel, INR and platelets count. However,patients who were non-responders had signi-ficantlyhigher pre-treatment alpha fetoprotein (AFP) levelsthan responders Conclusions. Treatment of CHCpati-ents with DAAs is associated with highersustained virologic response, particularly in easy-totreatpatients. AFP level may aid in prediction ofnon-responders to DAAs
Elhadidy Abdelmoneim
Medical Journal of Viral Hepatitis pp 53-55; doi:10.21608/mjvh.2020.80648

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Elbatae Hassan, Abdel-Razik Ahmed, Mousa Eman, Elshenaway Mostafa, AbdEl Monem Sameh, El Shabrawi Ahmed, Samir Amr, Mousa Nasser
Medical Journal of Viral Hepatitis pp 57-61; doi:10.21608/mjvh.2020.80651

The publisher has not yet granted permission to display this abstract.
Ibrahim Ibrahim, Elbadrawy Elsaid, Nasr Dina, El-Said Hanaa, AbdEl Monem Sameh
Medical Journal of Viral Hepatitis pp 75-80; doi:10.21608/mjvh.2020.80657

Abstract:
Background and aim. Mixed ascites is definedin patients in whom two or more etiologies of ascites aredemonstrated. Such patients have liver cirrhosis plus (an)other local and/or systemic cause(s). The aimof this workis to detect the frequency and characterization of mixedascites among cirrhotic patients. Patients and methods.The study was conducted on 273 ascitic cirrhotic patients.All patients were subjected to full history taking,thorough clinical examination, radiological investigationsand laboratory investigations including CRP andtumor markers (AFP, CEA, CA 19-9, CA 125).Diagnostic abdominal paracentesis with cytologic andbiochemical analyses and Ziehl- Neelsen staining ofascitic fluid were done. Also, serum-ascites albumingradient (SAAG) was calculated. Results. Twenty eightpatients (10.3%) among the studied patients were mixedascites. Among patients with mixed ascites, the mostcommon cause was malignancy in 11 patients (39.2%),cardiac causes were present in 7 patients (25%), renalcauses were found in 2 patients (7.1%) and surgicalabdominal causes were present in 8 patients (28.7%).Compared to non-mixed ascites, patients with mixed asciteshad a statistically significant increase regarding ascitictotal leucocytic count, SAAG, glucose, lactate dehydrogenaseand protein. Moreover, there was a significantincrease in tumor markers and CRP in patients with mixedascites versus patients with non-mixed ascites. Usinglogistic regression analysis, the predictor variables formixed ascites in cirrhotic patients included positivetumor markers CEA and CA 19-9 and positive CRP.Conclusion. in our study, the commonest cause ofmixed ascites was malignancy. Significant predictors ofmixed ascites were CRP and tumor markers; CEA, CA19-9 and CA 125.
Elbadrawy Elsaid, Zaher Tarik, Mousa Eman, Elshenaway Mostafa, Alhawarey Ahmed, Abdel-Aziz Mohamed, Elgamal Hoda
Medical Journal of Viral Hepatitis pp 63-68; doi:10.21608/mjvh.2020.80654

Abstract:
Hepatitis B infection is an internationalhealthcare problem, particularly in developing areas.The hepatitis B virus (HBV) is frequently transmittedvia body fluids such as blood, semen, and vaginalsecretions. The majority of adults infected with thevirus recover, however 5%-10% are not capable toclear the virus and become chronically infected. Theprincipal treatment goals for patients with hepatitisB infection are to prevent progression of the liverdisease to cirrhosis or hepatocellular carcinoma. Theeffective nucleos(t)ide analogs (NAs) against hepatitisB virus (HBV) has improved the outcome ofpatients with chronic hepatitis B (CHB). Specialpopulations infected with chronic HBV includethose with decompensated cirrhosis, organ transplantation,pregnancy, extrahepatic manifestations,immunosuppressive-chemotherapy, co-infections(HIV-HCV- HDV), renal failure, hepatitis B virusinfection in children/adolescents and dental practice.These populations vary in their natural history andrisk of liver-related complications, the indicationsfor anti-HBV treatment in addition to the recommendationsconcerning the HBV drugs used, timeof therapy and expected endpoints. The aim ofthis review is to summarize the information on therelevance and treatment of HBV infection in suchspecial populations.
Ahmed Ibrahim Alhawarey, Elalfy Hatem, Soliman Gamal, Okasha Hussein, El-Bendary Mahmoud
Medical Journal of Viral Hepatitis pp 81-86; doi:10.21608/mjvh.2020.80662

Abstract:
Background and study aim. Endoscopicultrasound (EUS) is a diagnostic modality that continuesto expand its clinical applications. The aim of this studyis to evaluate the diagnostic role of EUS in commonbile duct stones. Patients and methods: This study wascarried on 29 patients with suspected CBD stones fromthem only 15 patients were diagnosed as Common BileDuct stone(s). Endoscopic retrograde cholangiopancreatography(ERCP) is considered as gold standard fordiagnosis of CBD stones and compare EUS findingswith that of ERCP. Results: The diagnostic performanceof EUS shows that the sensitivity, specificity, PPV, NPVand accuracy of 100%, 92.8%, 93.7%, 100% and 96.5%respectively. It can catch 15 true positive cases withonly one false positive case and 13 of 14 true negativecases. EUS is considered as a minimally invasivemethod with low incidence of complications, allowingexact determination of the site and size of stones. SoEUS aid in better planning for CBD stone removal.Conclusion: EUS is considered as a minimally invasivemethod with low incidence of complications, allowingexact determination of the site and size of stones withgood diagnostic performance.
Mousa Nasser, El Shabrawi Ahmed, Abdelaziz Mohammed
Medical Journal of Viral Hepatitis pp 5-14; doi:10.21608/mjvh.2019.59521

Mousa Nasser, Elmoghazy Mohammad, El Shabrawi Ahmed
Medical Journal of Viral Hepatitis pp 15-21; doi:10.21608/mjvh.2019.59522

Mousa Nasser, Abdelaziz Mohammed, El Shabrawi Ahmed
Medical Journal of Viral Hepatitis pp 1-4; doi:10.21608/mjvh.2019.59520

El-Sayed Shiha Gamal, Aboud Alaa, Mahmoud Khalil Doaa, Salama Sieddek Asmaa
Medical Journal of Viral Hepatitis pp 45-52; doi:10.21608/mjvh.2019.59526

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