Medical Science Journal for Advance Research

Journal Information
ISSN / EISSN : 2776-3870 / 2774-4892
Published by: Research & Education Development (10.46966)
Total articles ≅ 18
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Saif Jabbar Yasir, Taghreed Abdul Kareem Al- Makhzoomy
Medical Science Journal for Advance Research, Volume 2, pp 80-94; https://doi.org/10.46966/msjar.v2i3.24

Abstract:
Prion diseases or transmissible spongiform encephalopathies (TSEs) are a family of rare progressive neurodegenerative disorders that affect both humans and animals. They are distinguished by long incubation periods, characteristic spongiform changes associated with neuronal loss, and a failure to induce inflammatory response. Prion diseases in animals, Scrapie in sheep, chronic wasting disease (CWD) in deer, bovine spongiform encephalopathy (commonly known as "mad cow disease") in cattle, and Creutzfeldt-Jakob disease in humans are all examples of infectious diseases. The prion protein (PrP) was identified in a patient in 2015, and it was previously believed to be the cause of all known mammalian prion diseases. However, The protein alpha-synuclein, which is thought to be responsible for MSA, was suggested to be the cause of the disease in 2015.
Nanda Ghoshal
Medical Science Journal for Advance Research, Volume 2, pp 45-49; https://doi.org/10.46966/msjar.v2i2.18

Abstract:
A 37 years, the old male patient reported the chief complaint of inability to open mouth since 10-11 months and recently pain and swelling resulting from wisdom teeth of both sides limited the mouth opening severely (15mm after 3 weeks, >22mm after 6 weeks,>27 mm after 9 weeks).
Murtadha M. Jawad
Medical Science Journal for Advance Research, Volume 2, pp 35-44; https://doi.org/10.46966/msjar.v2i2.17

Abstract:
This review deals with the world's most important problem, which is hepatotoxicity. As a result of the distinctive location of the liver and its effect on all the substances entering the body and manufactured from it, the wastes resulting from metabolism, as well as its functional nature in the equation and removal of toxins. Therefore, the liver is one of the most influential and first organs in the human body because of the major functions it shows. Therefore, most of the research targets the liver through a number of chemicals, including carbon tetrachloride. Carbon tetrachloride is widely used, and its work depends on destroying hepatocytes through a group of chemical reactions with a group of chemical compounds for the liver such as fats and proteins, thus producing harmful substances such as free radicals, whose damage depends on the concentration and period of exposure to carbon tetrachloride. In order to determine the extent of the influence of the liver, there must be evidence. Our choice of Regucalcin was because it is closely related to several physiological functions, including: its role in maintaining the level of calcium on a regular basis in addition to its anti-programmed effects of cell death by inhibiting factors that break down the DNA strand by inhibiting the action of a group of enzymes. And other factors that destroy cells. Thus, the presence of Regucalcin inside and out of cells is evidence of the extent of damage and damage to hepatocytes and their dissolution. Therefore, Regucalcin can be considered a criterion for assessing the extent and degree of damage to the liver.
Nanda Kishore Ghoshal
Medical Science Journal for Advance Research, Volume 2, pp 45-50; https://doi.org/10.46966/msjar.v2i2.19

Abstract:
Ulcerations are characterized by defects in the epithelium, underlying connective tissue, or both. Due to diversity of causative factors and presenting features, diagnosis of oral ulcerative lesions might be quite challenging. Tongue ulcers are open sores or cuts on the tongue. Tongue ulcers can be painful and raw and can be irritated by eating and drinking. One of the most common types of tongue ulcers is the canker sore, which may arise for an unknown reason or be linked to a number of different irritants. This article is an attempt to elaborate the treatment protocols with couple of case reports
Noor I. Abdul-Zahra, Zahraa K. Taiban
Medical Science Journal for Advance Research, Volume 2, pp 71-75; https://doi.org/10.46966/msjar.v2i2.22

Abstract:
This study was carried out in Middle Euphrates cancer center, laboratories department, Al-Najaf holy city - Iraq; Iraqi patients have been recorded during period January 2018 until December 2018. This study has demonstrated that four different types of the following cancers: Breast cancer, brain cancer, lung cancer and Bladder cancer were registered in this study. Comparison was occured among each type of cancer was regarded in sex, age and number. The highest levels of cancer among all the other types were breast and lung cancer , the majority results in cancer epidemiology for this study, which showed 22% and 8 % respectively. While in other types, the result has showed 6%, 4.7%,for Bladder cancer, and braian cancer, respectively
Sarah Ali Aljazaeri
Medical Science Journal for Advance Research, Volume 2, pp 76-79; https://doi.org/10.46966/msjar.v2i2.23

Abstract:
Neonatal hyperbilirubinemia results from a readiness for the bilirubin production in neonates and limited their ability to excrete it. The diagnosis of hyperbilirubinemia based on yellow discoloration of the skin and whiteness of eyes, idle in the child's movement and the lack of lactation. The baby seems sick or is difficult to awaken. Bilirubin is a tetrapyrrole pigment derived from breakdown product of normal heme catabolism in senescent red blood cells. Unconjugated bilirubin normal elevation is named newborn physiologic hyperbilirubinemia, whereas the level of bilirubin of infant normally to be a bit higher after birth, In the same context the placenta in the womb of the mother. Pathologic hyperbilirubinemia is defined as odd of bilirubin from the normal level so intervention required. Many reasons for this type of jaundice
Sarah Ali Aljazaeri
Medical Science Journal for Advance Research, Volume 2, pp 64-70; https://doi.org/10.46966/msjar.v2i2.21

Abstract:
Neonatal hyperbilirubinemia results from a readiness for the bilirubin production in neonates and limited their ability to excrete it. The diagnosis of hyperbilirubinemia based on yellow discoloration of the skin and whiteness of eyes, idle in the child's movement and the lack of lactation. The baby seems sick or is difficult to awaken. Serum cystatin-C, is a low molecular protein that belongs to the family of cysteine protease inhibitor, was proposed as an endogenous filtration marker. In this study sixty neonatal patients suffering from hyperbilirubinemia (35 males,25female) were collected from prematurity unit (PU) in Al-Zahra Educational Hospital/Al-Najaf Al-Ashraf during the period from August,2020 to February,2021. A group of 20 randomly (12male, 8female) selected apparently healthy group. After diagnosis of hyperbilirubinemia, the patients were divided into three groups according to age (1-3), (4-7) and (7-9) days. The result reveals that significant increase (p<0.05) in serum cystatin-C in neonatal hyperbilirubinemia as compared with healthy group. The result of study reveals no significant increase(p<0.05) in serum levels of cystatin-C, while the study shows a significant increase (p<0.05) between male and female in serum levels of bilirubin.
Gaung Eka Ramadhan
Medical Science Journal for Advance Research, Volume 2, pp 51-63; https://doi.org/10.46966/msjar.v2i2.20

Abstract:
This study analyzes the relationship between pictorial health warnings on cigarette packaging and the intention to quit smoking for Pamulang University students. This research design uses quantitative analysis with a cross-sectional method complemented by qualitative respondents, namely Pamulang University students totaling 100 respondents. This research was conducted from December 2019 – January 2020. The data analysis used univariate analysis, bivariate analysis, and multivariate analysis. The results showed that there was a significant relationship between perceptions of pictorial health messages and the intention to stop smoking, the p-value indicated this: 0.000 and the OR value 43.5; there is a significant relationship between knowledge and intention to stop smoking with a p-value: 0.000 and OR value 75.6;
Zainab Sajid Mohammed
Medical Science Journal for Advance Research, Volume 2, pp 25-28; https://doi.org/10.46966/msjar.v2i1.15

Abstract:
This study was conducted at the laboratory of histology and anatomy, Faculty of Medical and Health Techniques/Kufa, and laboratory of post Graduate/ Department of biology, Faculty of Science/University of Kufa, The present study was conducted to investigate the effect of Prazosin hydrochloride on some organs in male rats (Rattus norvegicus), about 25 mature male rats with the average body weight of 210-290gram and three months age were randomly divided into four groups (5rats / group). The first group was given orally with distilled water as a control group and the other groups (second, third, and fourth) were also given orally with three doses of Prazosin (25, 50,75 mg /kg. b.wt.) daily for a period of eight weeks. At the end of the treatment period (eight weeks), rats were sacrificed, blood samples obtained, and organs lung, and spleen. The histopathological changes of lungs in the rats treated with prazosin at dose 25 mg/kg.b.wt for 8-weeks showed emphysema and dilation in some of the alveoli, hemorrhage distributed inside the tissue of the lung, polymorphic nuclear infiltration due to pneumonia, the pulmonary artery revealed degenerative changes in the tunica media structure (smooth muscle) and hyperplasia in the connective tissue around pulmonary artery and alveoli. These symptoms which occur in rats treated with prazosin at dose 50 and 75 mg/kg b.wt. as well as the histopathological changes of rat lung demonstrate severe hemorrhage, emphysema, thickening in the wall of some alveoli, pneumocyte necrosis (pneumocyte type 1 and pneumocyte type 2), and showed exudate among lung tissue. Histopathological changes of Spleen in the rats treated with prazosin at doses(50 and75)mg/kg b.w. for 8-weeks revealed histopathological changes, which represented by proliferation in the white pulp lead to fused white pulp together and destruction of some components of red pulp, stenosis in many splenic venous sinuses, the germinal artery show thickening in the tunica media and stenosis occurs, degenerative change in many nuclei of lymphocytes, and proliferation in the component of the white pulp.
Assist. Prof. Dr. Wijdan Rajh Hamza Al-Kraity, Ali Hussein Faisal, Ali Nabeel Khaleel, Mahmoud Tuama Naeaam, Ali Sattar Jabar
Medical Science Journal for Advance Research, Volume 2, pp 10-14; https://doi.org/10.46966/msjar.v2i1.13

Abstract:
Coronary heart disease (CHD) is a generic designation for a group of related syndromes resulting from myocardial ischemia – an imbalance between cardiac blood supply (perfusion) and myocardial oxygen demand. Visfatin (VF) is a recently discovered adipokine with different functions, Visfatin is mainly found in visceral adipose tissue and mimics insulin in lowering plasma glucose levels and, Visfatin emerges as a player in the development and progression of atherosclerotic lesions by directly promoting smooth muscle cell proliferation, Aberrant angiogenesis is now considered a feature of the atherogenic process in both coronary and carotid diseases. This adipokine was previously known as a pre-B-cell colony-enhancing factor (PBEF) or Nicotinamide phosphoribosyltransferase (NAmPRTase or Nampt) an enzyme that in humans is encoded by the NAMPT gene and demonstrated to be an intracellular protein with a key enzyme role in nicotinamide adenine dinucleotide (NAD)
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