International Journal of Pharmaceutical Sciences and Medicine

Journal Information
EISSN : 2519-9889
Published by: Zain Publications (10.47760)
Total articles ≅ 115
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Goldha Faroliu
International Journal of Pharmaceutical Sciences and Medicine, Volume 7, pp 20-24; https://doi.org/10.47760/ijpsm.2022.v07i08.003

Abstract:
Balanophora elongata is categorized as Balanophoraceae which is the most found in West Sumatra on their family. The plants in similar family shown the potential as significant anti radical, cytotoxic in cancer and also have a role in toxification. The aim of this study is to know the antibacterial activity of this plant toward Pseudomonas aeruginosa. The method that we use is extraction and antimicrobial test with diffusion disc. The compound in extract consists of terpenoids / steroids, phenolics, flavonoids and negative alkaloid. The antibacterial activity was assayed with diffusion disc method. This study showed that Balanophora elongata is effective as anti-Pseudomonas aeruginosa. The isolates from this plant were obtained and need more characterization.
Fajrian Aulia Putra, Netty Suharti
International Journal of Pharmaceutical Sciences and Medicine, Volume 7, pp 1-9; https://doi.org/10.47760/ijpsm.2022.v07i08.001

Abstract:
Gandasuli (Hedycium coronarium.) is one of the native plants of Indonesia which It has been used as medicine by generations of people from generation to generation. This study aims to determine the acute toxicity of standardized ethanol extract of gandasuli rhizome (Hedycium coronarium.) against male white mice, Swiss webster strain. The method used is to determine the value of Ld 50 using the Thompson-weil method. In this study, the parameters observed were the toxicity value of the standardized ethanol extract of gandasuli rhizome based on the Ld 50 value, histopathology of the liver and kidneys. A total of 25 male Swiss Webster white mice were randomly divided into 5 groups, namely group 1 as a control, group 2 treated with ethanol extract of gandasuli rhizome at a dose of 4 g/KgBW, group 3 at a dose of 8 g/Kg BW, group 4 with a dose of 16 g/Kg BW and group 5 with a dose of 32 g/Kg BW. The results of observations for 24 hours found that animals died in groups 1,2,3,4 and 5 respectively, namely 0,0,0,3 and 5 of 5 test animals, 14.92 mg/KgBB which are categorized into the practically non-toxic category because they are in a dose range of 5 g/KgBW – 15 g/KgBW. Observation of acute toxicity was continued by observing the histopathological state of the organ within 24 hours. The organs observed were the kidneys and liver which were given toxic doses. Based on the results of histopathological observations of the liver and kidneys of mice, it showed the occurrence of liver cell necrosis at a toxic dose of 32 mg/KgBW and in the kidneys showed bleeding on the interstitial between tubule and edematous tubular cells.
Rahul Mandhan, Twinkle Garg
International Journal of Pharmaceutical Sciences and Medicine, Volume 7, pp 10-19; https://doi.org/10.47760/ijpsm.2022.v07i08.002

Abstract:
Sustained release drug delivery system is designed to sustain the release of the drug dosage forms at a predetermined rate. Sustained release formulation maintains uniform drug level in therapeutic window, improved efficacy of drug by localization at the site of action with better patient compliance, reducing the dose required, providing uniform drug delivery. The sustained release formulations minimize the frequency of drug administration and do not interfere with the therapeutic action of the drug. The use of sustained release matrix technology for antibiotics is effective in preventing the resistant of antibiotics in body on irrational use. Drug release through matrix SRDDS is determined by Polymer swelling, Water penetration, Drug dissolution, diffusion, Matrix erosion. The present article contains brief review on various formulation approaches for Sustained release drug delivery system, advantages, selection criteria for matrix SRDDS and use of cefixime trihydrate in formulating matrix SRDDS.
Tanwar Simran, Tikariya Komal, Sharma Vimukta
International Journal of Pharmaceutical Sciences and Medicine, Volume 7, pp 11-24; https://doi.org/10.47760/ijpsm.2022.v07i07.002

Abstract:
The main objective of the study is the formulation and evaluation of sustained release matrix tablet of Nimesulide using pomegranate peel and acacia as natural polymer. The preformulation study of Nimesulide was conducted and λmax was found at 300 nm. The sustained release matrix tablet was prepared using Pomegranate peel as Release rate retardant, Acacia as polymer, Polyvinylpyrrolidone K30 as Binder, Isopropyl alcohol as Granulation solution, Micro Crystalline Cellulose as Diluent, Magnesium stearate as Lubricant and Talc as Glidant. Several formulations were prepared by taking different drug concentration in Pomegranate peel (Release rate retardant) with varying ratio of binder to lubricants. Various formulations of sustained release matrix tablet of Nimesulide F1, F2, F3, F4, F5, F6 was prepared. The prepared granules were evaluated for different parameters like Bulk density, Tapped density, Angle of repose, Carr’s index, Hausner’s ratio which shows the excellent flow properties of formulation. The physical characteristic of Nimesulide sustained release matrix tablets (F1 to F6) such as thickness, diameter, hardness, friability, weight variation and drug content were determined and results of the formulations (F1 to F6) found to be within the limits specified in official books. The drug content of all the formulation were found to be in the range of 99.59 to 99.83 % w/w, which is within the specified limit as per Indian Pharmacopoeia 1996 (i.e. 90-110% w/w). The drug released from formulation F1 to F3 was found to be 93.7, 92.9 and 92.2 % for Nimesulide respectively. The drug released from formulation F4 to F6 was found to be 94.1, 93.9 and 92.8% for Nimesulide respectively. The release rate of F1 and F4 was found to be higher when compared to other formulations this is due to increase in the concentration of polymer. These results are indicating that has higher drug retarding ability for long duration. All the formulations were analyzed for stability testing. All the formulations from F1 to F6 were found to be stable.
Harshada Kanjane, Neil Sonawane, Sunanda Kokare
International Journal of Pharmaceutical Sciences and Medicine, Volume 7, pp 1-10; https://doi.org/10.47760/ijpsm.2022.v07i07.001

Abstract:
The study of medicine is a science as well as an art. Pharmaceutical oral solid dosage forms have been used widely for decades, mainly due to their ease of administration and suitability for systemic drug delivery. The tablets may be produced directly from powders, granule pellets, or film-coated multiple units. Nowadays, tablets are the most widely used dosage form, making up over 70% of all manufactured ethical pharmaceutical formulations. Tablets are solid pharmaceutical unit dosage forms that can be manufactured by compression or moulding. They can include medicinal ingredients with or without acceptable diluents. The treatment of numerous disastrous diseases in the modern day has benefited greatly from the traditional. Ashwagandha powder, an ayurvedic remedy made from the herb withania somnifera is used to treat a variety of conditions including osteoarthritis, type 2 diabetes, anxiety-related issues, and tumour healing abilities. Withaferin-A, Stigmosterol glucoside, and withanolide-D are the three chemical components of ashwagandha.
Rathore Antim, Tikariya Komal, Mukherjee Jayanti
International Journal of Pharmaceutical Sciences and Medicine, Volume 7, pp 39-58; https://doi.org/10.47760/ijpsm.2022.v07i06.002

Abstract:
Cubosomes can be considered as novel lipid-based nanosystems similar to well-known vesicular systems such as liposomes and niosomes. Cubosomes have been widely formulated using certain amphiphilic lipids (e.g. glyceryl monooleate and phytantriol) in the presence of a suitable stabilizer. They can represent a novel drug delivery system which could be loaded with hydrophilic, lipophilic and amphiphilic drug molecules. They are widely used for various drug delivery applications such as oral, ocular, transdermal and chemotherapy drug delivery. In this study, preparation and characterization of cyclosporine loaded cubosomes have done for the management of psoriasis. The preformulation study and formulation of cubosomes was performed. Evaluation parameters of the cubosomes were performed and results were reported.
Lawrence Mayo, Georgiana Farrugia Bonnici, Andrei Agius Anastasi
International Journal of Pharmaceutical Sciences and Medicine, Volume 7, pp 70-82; https://doi.org/10.47760/ijpsm.2022.v07i06.004

Abstract:
BACKGROUNDː Exercise forms a crucial part of any rehabilitation program and is a key tool in inpatient therapy. The patients’ own perceived roles and benefits of exercise after discharge from hospital is pivotal in determining whether physical activity and exercise are continued within the community. Furthermore, the perception of the role of sports, as a separate entity from exercise, is also unknown, in spite of its several known benefits. METHODSː All patients under 75 years of age, that were admitted for inpatient rehabilitation between 2018 and 2019 to Karin Grech Rehabilitation Hospital (Malta) were invited to participate in a telephone based questionnaire. This questionnaire was aimed at identifying the patients’ views related to the roles of exercise and sports in their lives prior to their admission to hospital, and how such views have changed after being discharged from inpatient rehabilitation. RESULTSː Out of 165 patients that were recruited for the study, 93 patients have responded to the telephone based questionnaire. Most participants have reported that they have strongly agreed that exercise has helped in improving their quality of life (QOL) (62%), mental well-being (61%) and social life (52%). Similar results for views related to sports have also been obtained. Post rehabilitation, 65% of patients have stated that they were participating in a form of exercise, compared to 37% before rehab (χ2 = 42.3, p = 0.00 (p < 0.05)). The barriers limiting participation in exercise and sports were found to be personal (financial = 61%, lack of time =47% and dependence on others = 33%) as well as environmental (lack of suitable facilities = 42%, lack of assistance by trained personnel = 36% and lack of accessibility =33%). CONCLUSIONS: Individuals discharged following inpatient rehabilitation were significantly more prone to be participating in exercise or sports 1 year after discharge. Both personal and environmental barriers have been identified limiting participation. Work is needed in promoting changes in infrastructure that would facilitate participation as well as guidelines aimed at maximising exercise promotion in patients post rehabilitation.
International Journal of Pharmaceutical Sciences and Medicine, Volume 7, pp 1-38; https://doi.org/10.47760/ijpsm.2022.v07i06.001

Abstract:
This Review focuses on the Recent Developments in Analytical Techniques for Estimation of Valsartan and Sacubitril Alone or in combination with other drugs in various Biological media like Human plasma and urine. The main Objective of this Review is to Unify and Interpret widely Scattered information of reported studies on Potential, Reliable and efficient Analytical Methodologies which can Estimate All the Major Components of Antihypertensive drugs. The information and suggested outlined below may facilitate and guide further Needed studies to optimise the use of Analytical Techniques like HPLC (High Performance Liquid Chromatography), HPTLC ( High Performance Thin Layer Chromatography), GC ( Gas Chromatography) etc. for determination of Antihypertensive Analytes in formulation. The presented work is focused on the use of different Analytical Methods for the estimation of Valsartan and Sacubitril in API as well as formulation. From the Reviewed Literature it is obvious that HPLC is a commonly Available method of testing in Pharmaceutical Laboratory.
Bhadoria Juhi, Likhariya Manoj
International Journal of Pharmaceutical Sciences and Medicine, Volume 7, pp 59-69; https://doi.org/10.47760/ijpsm.2022.v07i06.003

Abstract:
Oral delivery is current standard in the pharmaceutical industry wherever it is regarded as the safest, most suitable and most economical method of drug delivery. The oral cavity is an attractive site for the administration of drugs because of ease of administration. Oro-dispersible drug delivery system are Novel Drug Delivery techniques that make the tablets disintegrate in the mouth without chewing and water, and immediate release and enhanced bioavailability, with better patient compliance. Orodispersible tablets (ODTs), also known as fast melt, quick melts, fast disintegrating have the unique property of disintegrating in the mouth in seconds without chewing and the need of water. Recently, the European Pharmacopeia adopted the term Orodispersible tablet for a tablet that disperses or disintegrates within a minute or second in the mouth before swallowing. Natural polymers remain attractive primarily because they are natural products of plants, readily available, inexpensive, and capable of multitude of chemical modification. Leaves of Hibiscus rosa sinensis Linn (Family: Malvaceae) contains high proportion of mucilage which can be used as additives in pharmaceutical formulations. The investigation of polysaccharides isolated from leaves of Hibiscus rosa sinensis Linn mucilage as a superdisintegrant in the formulation development of Orodispersible Tablets.
Grusha Kamat, Kunal Naidu, Shweta Pandey, Renu Kunkekar, Rutuja Jadhav
International Journal of Pharmaceutical Sciences and Medicine, Volume 7, pp 87-96; https://doi.org/10.47760/ijpsm.2022.v07i05.008

Abstract:
Transdermal patches containing antihypertensive drugs are preferable to conventional-dose forms because they minimize administration frequency, are less intrusive, and cause no gastrointestinal upset. Candesartan is an angiotensin-converting enzyme inhibitor that can be used alone or in combination with other drugs to treat hypertension. It may also be used as an alternative agent for the treatment of heart failure, myocardial infarction, and coronary artery disease. A transdermal patch is superior to oral administration as it avoids first past metabolism and delivers the drug for a prolonged duration. It might be the best option for the treatment and management of hypertension. The objective of this study is to develop a well-designed, stable, effective, and safe dosage form for the delivery of antihypertensive drugs.
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