British Journal of Dermatology

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ISSN / EISSN : 0007-0963 / 1365-2133
Current Publisher: Wiley (10.1111)
Former Publisher:
Total articles ≅ 61,698
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, , A. Alavi, S. Brooks, V. Piguet
Published: 9 June 2021
by Wiley
British Journal of Dermatology; doi:10.1111/bjd.20566

The publisher has not yet granted permission to display this abstract.
, K.B. Gordon, , , M. Miller, Y.K. Shen, Y. You, C. Han, Y.W. Yang, P. Foley, et al.
Published: 9 June 2021
by Wiley
British Journal of Dermatology; doi:10.1111/bjd.20568

Abstract:
Background Psoriasis is a chronic disease requiring long-term therapy. Objectives Physician- and patient-reported outcomes (PROs) were evaluated through week 252 in VOYAGE 1 and VOYAGE 2. Methods A total of 1829 patients were randomized at baseline to receive guselkumab 100 mg every-8-weeks, placebo, or adalimumab; placebo patients crossed-over to guselkumab at week 16. Adalimumab patients crossed-over to guselkumab at week 52 in VOYAGE 1, and randomized-withdrawal/retreatment occurred at weeks 28-76 in VOYAGE 2; all patients then received open-label guselkumab through week 252. Efficacy and HRQoL endpoints were analyzed through week 252. Safety was monitored through week 264. Results The proportions of patients in the guselkumab group who achieved clinical responses at week 252 in VOYAGE 1 and VOYAGE 2, respectively, were: 84.1% and 82.0% (PASI90); 82.4% and 85.0% (IGA0/1); 52.7% and 53.0% (PASI100); and 54.7% and 55.5% (IGA0). HRQoL endpoints were achieved as follows: 72.7% and 71.1% of patients (Dermatology Life Quality Index 0/1 or no effect on patient’s life); 42.4% and 42.0% (Psoriasis Symptoms and Signs Diary [PSSD] symptom score=0); and 33.0% and 31.0% (PSSD sign score=0). In VOYAGE 2 only, approximately 45% of patients achieved ≥5-point reduction in SF-36 Physical/Mental component scores and 80% reported no anxiety/depression (Hospital Anxiety and Depression scores <8). Similar findings were reported for adalimumab crossovers. These effects were maintained from week 52 in VOYAGE 1 and week 100 in VOYAGE 2. No new safety signals were identified. Conclusions Guselkumab maintains high levels of clinical response and PRO improvement through 5 years in patients with moderate-to-severe psoriasis.
, M. Harries, A. Tosti, W. Bergfeld, U. Blume‐Peytavi, V. Callender, V. Chasapi, O. Correia, G. Cotsarelis, R. Dhurat, et al.
Published: 9 June 2021
by Wiley
British Journal of Dermatology; doi:10.1111/bjd.20567

The publisher has not yet granted permission to display this abstract.
, V. Ren
Published: 9 June 2021
by Wiley
British Journal of Dermatology; doi:10.1111/bjd.20565

The publisher has not yet granted permission to display this abstract.
E. Hwang,
Published: 9 June 2021
by Wiley
British Journal of Dermatology; doi:10.1111/bjd.20571

Abstract:
Autoimmune blistering diseases (AIBD) are often treated with immunosuppressive medications, including rituximab, yet the implications of these approaches during the COVID-19 pandemic are not fully understood. COVID-19 outcome studies in AIBD patients are limited by small sample sizes and interpretation complicated by advanced ages and comorbidities common in this population.
T. Guillaume, E. Puzenat, D. Popescu, F. Aubin,
Published: 9 June 2021
by Wiley
British Journal of Dermatology; doi:10.1111/bjd.20569

The publisher has not yet granted permission to display this abstract.
Published: 6 June 2021
by Wiley
British Journal of Dermatology, Volume 184; doi:10.1111/bjd.20121

Abstract:
Linked Article: Laskar et al. Br J Dermatol 2021; 184:1085–1093. 黑色素瘤是一种癌症形式, 可以发生在任何部位的皮肤上。它是澳大利亚第三常见的侵入性癌症, 也是英国第五常见的癌症。风险因素包括日晒、皮肤类型、发色、痣和遗传因素。然而, 根据黑色素瘤所出现部位的不同, 其在人体内的形成途径可能不同。这意味着, 在不同身体部位, 这些风险因素导致黑色素瘤的程度可能会有所不同。 我们在英国和澳大利亚进行了一项研究来调查这一想法, 研究对象为 2,617 名黑色素瘤患者和 975 名非黑色素瘤患者。我们研究了各种风险因素对不同身体部位造成的黑色素瘤风险是否不同, 这些风险因素包括痣、头发、眼睛和肤色、雀斑、晒伤倾向、日晒或日光浴以及基因。 我们发现, 痣多的人, 躯干、手臂和手部患黑色素瘤的风险显著提升, 头部或颈部患黑色素瘤的风险略有提升。肤色白皙的人腿部、脚部、头部和颈部患黑色素瘤的风险高于躯干。相比之下, 其他风险因素导致不同身体部位患黑色素瘤的风险程度相当, 包括遗传风险因素。 我们的结果支持这样的观点, 即黑色素瘤有不同的形成途径。
Published: 6 June 2021
by Wiley
British Journal of Dermatology, Volume 184; doi:10.1111/bjd.20127

Abstract:
Linked Article: Assaf et al. Br J Dermatol 2021; 184:1153–1160. 寻常型天疱疮 (PV) 是一种危及生命的疾病, 可能会导致皮肤以及口腔、鼻子、喉咙、眼睛和生殖器部位的粘膜出现严重水疱。皮肤上的水疱是由于针对组织中负责细胞间相互附着 (细胞-细胞粘附) 的蛋白质的自身抗体形成的。 我们之前发现, 一种名为 ST18 的基因的变异体会导致患这种疾病的风险增加。我们发现, 该基因变异体会导致皮肤细胞产生更多的 ST18 蛋白, 进而导致促炎介质 (特别是肿瘤坏死因子-α,TNF-α) 的分泌增加, 并削弱细胞之间的联结强度。因此, 我们开始探索能够促使 ST18 破坏细胞-细胞粘附的机制。 通过几种方法, 我们发现 ST18 会直接激活 TNF-α 的生成, 从而破坏细胞-细胞粘附的稳定性, 进而导致水疱的形成。然后, 我们观察了患者自身的皮肤, 发现携带 ST18 风险变异体的受影响个体同时表达 ST18 和 TNF-α 的数量更多; 这些人员的疾病种类也更广泛。综上所述, 这些观察结果表明了 TNF-α 在与 ST18 基因变异相关的 PV 形成中发挥的作用。 ST18 的基因检测可能有助于预测哪些 PV 患者更有可能从 TNF-α 阻断剂的治疗中获益。
Published: 6 June 2021
by Wiley
British Journal of Dermatology, Volume 184; doi:10.1111/bjd.20103

Abstract:
Linked Article: Wang et al. Br J Dermatol 2021; 184:1068–1076. Atopic dermatitis (also known as atopic eczema) is a common inflammatory skin disease characterized by intense itch. Approximately 20% of children and 3% of adults are affected by this skin disease worldwide, and the number of individuals with it has increased threefold in industrialized nations since the 1970s. Although occurring primarily during childhood, atopic dermatitis has become more common in Chinese adults in recent years, potentially because of interactions between genetic and environment factors. In this Chinese study, we assessed the short-term association between air pollution and hospital visits because of atopic dermatitis. We obtained patients’ records for atopic dermatitis from the Guangzhou Municipal Clinical Center for Dermatology between January 2013 and December 2017. We further divided up our study population by age and season to assess links in different subgroups. From 29,972 hospital visits for atopic dermatitis in Guangzhou, China, we found both acute effects and delayed effects of air pollution on hospital visits for this condition. Stronger effects were observed in the cool season, approximately 1·7–3·0 times higher than those in the warm season. Stronger effects were also observed among children, approximately 1·3–1·8 times higher than those among adults. In conclusion, air pollution might be an important trigger for atopic dermatitis in subtropical Guangzhou, China. Children are more vulnerable than adults and effects are stronger in the cooler season. This result alerts dermatologists to the potential effect of air pollution on atopic dermatitis.
Published: 6 June 2021
by Wiley
British Journal of Dermatology, Volume 184; doi:10.1111/bjd.20104

Abstract:
Linked Article: Ebens et al. Br J Dermatol 2021; 184:1161–1169. Epidermolysis bullosa (EB) is a group of genetic disorders with abnormally fragile skin. Recessive dystrophic EB (RDEB) is a particular subtype in which the skin lacks type VII collagen and cannot form anchoring fibrils essential for skin integrity. Blisters turn into painful, scarring wounds that persist and recur despite standard treatments. Skin grafting using the patient’s own skin does not solve the problem, and healthy donor skin is rejected. Better treatments are needed. Bone marrow transplantation (BMT) has been tried in RDEB with limited success. Immune-suppressing drugs, given after BMT to prevent rejection, are stopped when the patient becomes tolerant of the donor cells. Perhaps those patients might now tolerate skin grafts from their original bone marrow donor. As part of a study of BMT in RDEB, doctors in Minnesota, USA tested this, using a CelluTomeTM device to harvest 5 cm2 skin patches from donors. Starting 6 months after BMT they grafted up to nine wounds in each of eight patients with RDEB. Donors and patients found the outpatient procedures acceptable. Treated wounds became on average 75% smaller after 6 weeks, 95% smaller after 12 weeks and completely healed at 1 year. A skin biopsy from a grafted wound at 12 months showed healthy type VII collagen and normal anchoring fibrils, with 42% of donor cells compared with 16% in nongrafted skin. This method also healed surgical wounds following an operation on RDEB scarred hands. The authors conclude that grafting of chronic RDEB wounds with BMT donor tissue is simple, safe and successful.
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