Indian Journal of Dermatology, Venereology and Leprology

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ISSN / EISSN : 0378-6323 / 0973-3922
Published by: Scientific Scholar (10.4103)
Total articles ≅ 4,735
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Latest articles in this journal

Daniel Rizo-Potau, Ignasi Marti-Marti, Encarnación Martin-Ortega
Indian Journal of Dermatology, Venereology and Leprology pp 1-2; https://doi.org/10.4103/ijdvl.ijdvl_1095_19

Chi-Hui Wang, Chau Yee Ng
Indian Journal of Dermatology, Venereology and Leprology, Volume 87, pp 831-832; https://doi.org/10.4103/ijdvl.ijdvl_257_19

Vishal Gupta, Ananya Sharma, Neena Khanna, Swati Mahajan, Asit Ranjan Mridha
Indian Journal of Dermatology, Venereology and Leprology pp 1-3; https://doi.org/10.4103/ijdvl.ijdvl_448_19

Shekhar Neema, S. Radhakrishnan
Indian Journal of Dermatology, Venereology and Leprology pp 1-2; https://doi.org/10.4103/ijdvl.ijdvl_333_20

Zülküf Arslan, Tubanur Çetinarslan, Zülfikar Ulaş Bali, Mustafa Kürşat Evrenos, Peyker Temiz, Aylin Türel Ermertcan
Indian Journal of Dermatology, Venereology and Leprology, Volume 87, pp 878-880; https://doi.org/10.4103/ijdvl.ijdvl_265_19

Xue Gang Xu, Chao Zhang, Jie Qin, Xing Hua Gao, Liang Zhang
Indian Journal of Dermatology, Venereology and Leprology pp 1-2; https://doi.org/10.4103/ijdvl.ijdvl_1094_19

Geetali Kharghoria, Prashant Ramteke, Asit Ranjan Mridha, Vishal Gupta
Indian Journal of Dermatology, Venereology and Leprology pp 1-2; https://doi.org/10.4103/ijdvl.ijdvl_1016_19

Mona Abdel-Halim Ibrahim, Abdelrahman Mohamed,
Indian Journal of Dermatology, Venereology and Leprology, Volume 87, pp 819-825; https://doi.org/10.4103/ijdvl.ijdvl_1011_18

Abstract:
Hypopigmented mycosis fungoides is a rare variant of mycosis fungoides that may mimic many benign inflammatory hypopigmented dermatoses, and as yet there is no identified marker to differentiate between them. The aim of this study was to study the expression of thymocyte selection–associated high-mobility group box (TOX) in hypopigmented mycosis fungoides and one of its inflammatory mimickers (early active vitiligo) to assess its potential as a differentiating diagnostic marker. A case–control study was done using immunohistochemical analysis of TOX expression in 15 patients with hypopigmented mycosis fungoides and 15 patients with early active vitiligo. Immunohistochemical analysis was done via a semi-quantitative method and an image analysis method. Hypopigmented mycosis fungoides showed a statistically significant higher expression of TOX than early active vitiligo. The expression of TOX was positive in a majority of hypopigmented mycosis fungoides cases (14 cases, 93.3%), while only one case (6.7%) of vitiligo was weakly positive. TOX also displayed 93.3% sensitivity and specificity, with a cut-off value of 1.5. This was a pilot study testing hypopigmented mycosis fungoides against only a single benign inflammatory mimicker (early vitiligo). Other benign mimickers were not included. Our findings showed that TOX expression can differentiate hypopigmented mycosis fungoides from early active vitiligo which is one of its benign inflammatory mimickers, with a high degree of sensitivity and specificity.
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