Archives of Dermatology
ISSN / EISSN : 0003-987X / 1538-3652
Published by: Rockefeller University Press (10.1001)
Total articles ≅ 45,639
Latest articles in this journal
Archives of Dermatology, Volume 148, pp 1425-1427; https://doi.org/10.1001/2013.jamadermatol.215
We read with interest, the study by Tey et al,1 describing the usefulness of a portable video player for preschool children undergoing removal of cutaneous viral warts. The authors report significant reduction in anxiety scores with this intervention. However, actual clinical benefits seem to be modest, if at all present. There were no significant differences in treatment time, time required to persuade the child to cooperate, or the need for restraints. The authors, quoting qualitative data, mention that using the video player lessened the likelihood of prematurely stopping treatment, but the number of such stoppages is not reported, and the number of patients for whom restraints were required (a proxy measure) did not differ between groups.
Archives of Dermatology, Volume 148, pp 1428-1429; https://doi.org/10.1001/2013.jamadermatol.23
We report a case of hidradenitis suppurativa and eruptive melanocytic nevi associated with a keratosis pilaris (KP)-like eruption from vemurafenib, lending further insight into keratinocyte differentiation and melanocyte proliferation pathways. A 51-year-old man with a history of an 8-mm nodular melanoma on the scalp underwent wide local excision with radical lymph node dissection. Nineteen of 23 lymph nodes were found to be positive for disease, and he underwent 1 year of high-dose interferon alfa-2b therapy in 2009. After recurrent lymphatic disease was found on positron-emission tomography in March 2010, he underwent another right posterior neck lymph node dissection followed by irradiation. Over the next year, multiple chemotherapy regimens including temozolomide and carboplatin/paclitaxel failed to halt disease progression.
Archives of Dermatology, Volume 148, pp 1-3; https://doi.org/10.1001/2013.jamadermatol.357
Archives of Dermatology, Volume 148, pp 1411-1411; https://doi.org/10.1001/archderm.148.12.1411-b
Case Report from JAMA Dermatology — Acrally Distributed Purpuric and Necrotic Lesions With Pustular Features—Quiz Case
Archives of Dermatology, Volume 148, pp 1357-1359; https://doi.org/10.1001/archdermatol.2012.2221
Case Report from JAMA Dermatology — Successful Treatment of Recurrent Idiopathic Plantar Eccrine Hidradenitis With Colchicine
Archives of Dermatology, Volume 148, pp 1360-1363; https://doi.org/10.1001/archdermatol.2012.2894
Lasers were first used to treat tattoos in the 1960s.1 The use of quality-switching lasers (also known as Q-switching or QS lasers) beginning in the 1980s revolutionized the way tattoos and pigmented lesions were treated and became the gold standard treatment for tattoo removal.2 To achieve selective photothermolysis, sufficient energy to damage the target needs to be delivered with a pulse duration that is less than the thermal relaxation time of the target, which is itself defined by the size and shape of the target.3 The smaller the target, the shorter the thermal relaxation time and therefore the shorter the laser pulse duration required.
Archives of Dermatology, Volume 148, pp 1386-1392; https://doi.org/10.1001/archdermatol.2012.2974
Dermoscopy improves the diagnostic accuracy for melanocytic and nonmelanocytic pigmented lesions compared with inspection with the unaided eye.1-4 It is a valuable tool for pigmented and nonpigmented skin lesions. Dermoscopic criteria have been described for pigmented and nonpigmented Bowen disease (intraepithelial carcinoma)5-9 and actinic keratosis,10,11 two superficial forms of squamous cell carcinoma (SCC). However, few studies12-18 have reported dermoscopic features of invasive cutaneous SCC or keratoacanthoma. A recent study19 focused on a progression model of actinic keratosis and intraepidermal carcinomas to invasive carcinoma but was limited to facial cases and did not contrast dermoscopic features of SCC with those of other malignant or benign nonpigmented neoplasms. The study aims to better characterize the dermoscopic features of SCC and keratoacanthoma and to explore dermoscopic criteria that differentiate them from each other and from other nonpigmented skin lesions.
Archives of Dermatology, Volume 148, pp 1399-1402; https://doi.org/10.1001/archdermatol.2012.3022
Background Paronychia has been reported in as many as 10% of patients treated with gefitinib. Although conservative management and treatment with topical or systemic antibiotics are beneficial, no effective method exists for intractable cases. Platelet-rich plasma (PRP) consists of a high concentration of platelets that promote wound healing through chemotaxis, cell proliferation, angiogenesis, and tissue remodeling. Observations We herein report a refractory case of gefitinib-induced paronychia successfully treated with autologous PRP. A 68-year-old woman who had been diagnosed as having lung adenocarcinoma with multiple bone and brain metastases initiated gefitinib therapy at an oral dose of 250 mg/d. After 1 month, multiple paronychia with periungual granulation appeared on the nail fold of the first, second, and third toenails of both feet. Because the paronychia recurred repeatedly despite use of a topical antibiotic, topical corticosteroid, and short-term systemic antibiotic, she started PRP treatment. After 3 months, the lesion showed marked improvement with minimal pain or discharge. Conclusion This case highlights the therapeutic challenges of using PRP to promote tissue repair in intractable gefitinib-induced paronychia and merits further investigation.
Archives of Dermatology, Volume 148; https://doi.org/10.1001/archderm.148.12.1412-d