ISSN / EISSN : 2366-7478 / 2366-7478
Published by: Wiley-Blackwell (10.1002)
Total articles ≅ 634
Latest articles in this journal
Advanced Biosystems, Volume 4; https://doi.org/10.1002/adbi.202070123
In article number 2000003, Hyungsoon Im and co‐workers label extracellular vesicles, which are nanoscale phospholipid vesicles secreted by cells, with fluorescently conjugated antibodies. The fluorescence signals are amplified by periodic gold nanohole structures based on surface plasmon resonance. Multi‐fluorescence imaging enables multiplexed analyses of proteins with improved sensitivities.
Advanced Biosystems, Volume 4; https://doi.org/10.1002/adbi.202000475
Advanced Biosystems, Volume 4; https://doi.org/10.1002/adbi.202070122
Advanced Biosystems, Volume 4; https://doi.org/10.1002/adbi.202070121
Intratumoral heterogeneity plays a major role in rendering conventional and targeted therapies for glioblastoma ineffective. In article number 1900312, Bakhos A. Tannous and co‐workers demonstrate that extracellular vesicles can induce mesenchymal transition and treatment resistance in recipient proneural glioblastoma stem cells. The findings may point to novel treatment strategies for glioblastoma and indicate the involvement of extracellular vesicles in mesenchymal transition of other tumor types.
Advanced Biosystems, Volume 4; https://doi.org/10.1002/adbi.202070116
Advanced Biosystems, Volume 4; https://doi.org/10.1002/adbi.202070113
In article number 2000114, Luca Berdondini and co‐workers present 3D neurospheroids with self‐standing silicon microdevices internalized at different levels. Results are obtained by uncovering the control capability of silicon surface engineering to drive microdevices at predefined sites during cellular aggregation and 3D growth. This work paves the way to bionic brain‐tissue models with inbuilt untethered bioelectronic sensors and actuators.
Advanced Biosystems, Volume 4; https://doi.org/10.1002/adbi.202070111
Mitochondrial function is central to human health and has been recently shown to be modulated by magnetic field‐induced TRPC1 (red) activation. In article number 2000146, Petra S. Dittrich, Alfredo Franco‐Obregón, and co‐workers show that cell‐derived vesicles from wild type muscle are capable of reinstating lost mitochondrial sensitivity to magnetic fields in muscle cells in which TRPC1 had been genetically silenced.
Advanced Biosystems, Volume 4; https://doi.org/10.1002/adbi.202070114
In article number 2000127, Clara R. Correia, João F. Mano, and co‐workers describe the high‐throughput production of alginate‐based microgels with defined geometries using an in situ crosslinking procedure. This encapsulation system is surrounded by a permselective polymeric membrane that wraps cells and microparticles in a liquefied environment. The proposed system can potentially be explored as building blocks for bottom‐up strategies within the concept of modular tissue engineering.
Advanced Biosystems, Volume 4; https://doi.org/10.1002/adbi.202070112
In article number 2000123, João F. Mano, José Paulo S. Farinha, Carlos Baleizão, and co‐workers present novel multi‐bioactive mesoporous silica nanoparticles that release calcium, phosphate, and dexamethasone to induce osteogenic differentiation of human bone marrow mesenchymal stem cells with a single‐dose administration and no further osteogenic supplementation. The process simplifies bone regeneration and offers excellent prospects to bio‐instruct stem cells to differentiate in 3D environments. Cover based on the painting “Osteogenesis” by Ana Tristany.
Advanced Biosystems, Volume 4; https://doi.org/10.1002/adbi.202070115
In article number 2000160, Rahim Esfandyarpour and co‐workers present a machine‐learning‐assisted‐nanoparticle‐printed biochip for single‐cell analysis. It integrates powerful machine‐learning techniques, microfluidics, and easily accessible inkjet‐printing. The biochip is envisioned to have potential applications in single‐cell studies, tumor heterogeneity studies, and perhaps in point‐of‐care diagnostics‐ especially in developing countries where the cost, limited infrastructures, and limited access to medical technologies are of utmost importance.