Analytical and Bioanalytical Chemistry

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ISSN / EISSN : 0937-0633 / 1432-1130
Current Publisher: Springer Science and Business Media LLC (10.1007)
Former Publisher: , Springer Science and Business Media LLC (10.1007) , Springer Science and Business Media LLC (10.1007) , Springer Science and Business Media LLC (10.1007) , Springer Singapore (10.1007) Springer Science and Business Media LLC (10.1007)
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, Kathryn M. Nesbitt, Adrian C. Michael
Analytical and Bioanalytical Chemistry pp 1-11; doi:10.1007/s00216-021-03300-z

Abstract:
The neurochemical transmitter dopamine (DA) is implicated in a number of diseases states, including Parkinson’s disease, schizophrenia, and drug abuse. DA terminal fields in the dorsal striatum and core region of the nucleus accumbens in the rat brain are organized as heterogeneous domains exhibiting fast and slow kinetic of DA release. The rates of dopamine release are significantly and substantially faster in the fast domains relative to the slow domains. The striatum is composed of a mosaic of spatial compartments known as the striosomes (patches) and the matrix. Extensive literature exists on the spatial organization of the patch and matrix compartments and their functions. However, little is known about these compartments as they relate to fast and slow kinetic DA domains observed by fast scan cyclic voltammetry (FSCV). Thus, we combined high spatial resolution of FSCV with detailed immunohistochemical analysis of these architectural compartments (patch and matrix) using fluorescence microscopy. Our findings demonstrated a direct correlation between patch compartments with fast domain DA kinetics and matrix compartments to slow domain DA kinetics. We also investigated the kinetic domains in two very distinct sub-regions in the striatum, the lateral dorsal striatum (LDS) and the medial dorsal striatum (MDS). The lateral dorsal striatum as opposed to the medial dorsal striatum is mainly governed by fast kinetic DA domains. These finding are highly relevant as they may hold key promise in unraveling the fast and slow kinetic DA domains and their physiological significance. Graphical abstract
Ángel L. Morales-Cruz, Bonny M. Ortiz-Andrade, Joselyn Del Pilar-Albaladejo, , Uriel Rivera-González,
Analytical and Bioanalytical Chemistry pp 1-9; doi:10.1007/s00216-021-03243-5

Jan Kotoucek, Renata Hezova, Alena Vrablikova, Frantisek Hubatka, Pavel Kulich, Stuart Macaulay, Dierk Roessner, Milan Raska, Ivan Psikal,
Analytical and Bioanalytical Chemistry pp 1-13; doi:10.1007/s00216-021-03323-6

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Rebecca Brendel, Sascha Rohn,
Analytical and Bioanalytical Chemistry pp 1-10; doi:10.1007/s00216-021-03306-7

Abstract:
The ion mobility spectra of the isomeric monoterpenes α-pinene, β-pinene, myrcene, and limonene in drift tube ion mobility spectrometry (IMS) with 3H radioactive ionization are highly similar and difficult to distinguish. The aim of this work was to enhance the selectivity of IMS by the addition of nitrogen monoxide (NO) as dopant and to investigate the underlying changes in ion formation responsible for the modified ion signals observed in the ion mobility spectra. Even though 3H-based-IMS systems have been used in hyphenation with gas chromatography (GC) for profiling of volatile organic compounds (VOCs), the investigation of ion formation still remains challenging and was exemplified by the investigated monoterpenes. Nonetheless, the formation of monomeric, dimeric, and trimeric ion clusters could be tentatively confirmed by a mass-to-mobility correlation and the highly similar pattern of ion signals in the monomer region was attributed to isomerization mechanisms potentially occurring after proton transfer reactions. The addition of NO as dopant could finally lead to the formation of additional product ions and increased the selectivity of IMS for the investigated monoterpenes as confirmed by principal component analysis (PCA). The discrimination of monoterpenes in the volatile profile is highly relevant in the quality control of hops and was given as the example for application. The results indicate that additional product ions were obtained by the formation of NO+ adduct ions, next to hydride abstraction, charge transfer, or fragmentation reactions. This approach can potentially leverage selectivity issues in VOC profiling of complex matrices, such as food matrices or raw materials in combination with chemometric pattern recognition techniques. Graphical abstract
Zhenqing Li, Debao Xu, ,
Analytical and Bioanalytical Chemistry pp 1-7; doi:10.1007/s00216-021-03292-w

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Amanda Vaughn, Rachel J. DeHoog, Livia S. Eberlin,
Analytical and Bioanalytical Chemistry pp 1-10; doi:10.1007/s00216-021-03308-5

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M. S. Goryunova, V. K. Arzhanik, S. K. Zavriev,
Analytical and Bioanalytical Chemistry pp 1-12; doi:10.1007/s00216-021-03322-7

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Kehui Zhang, , Xin Xue, Mingyue Luo, Xiuhui Liu,
Analytical and Bioanalytical Chemistry pp 1-11; doi:10.1007/s00216-021-03312-9

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Lili Zhang, Ziyu Zhang, Yu Tian, Meihui Cui, Beibei Huang, , Shufang Zhang,
Analytical and Bioanalytical Chemistry pp 1-11; doi:10.1007/s00216-021-03316-5

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