The Gazette of Medical Sciences

Journal Information
EISSN : 2692-4374
Published by: Inovacus Publication (10.46766)
Total articles ≅ 69
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K. E. Thorp, James A. Thorp
The Gazette of Medical Sciences, Volume 2, pp 14-25; https://doi.org/10.46766/thegms.medphys.21100603

Abstract:
At the turn of the 20th century medicine and physics seemed to be heading in two opposing if not mutually exclusive directions: medical science had asserted the primacy of the cell and had set out to integrate known chemical principles into cellular functioning; physics, on the other hand, had broken through the barriers of classical Newtonian mechanical laws and established the energetic basis of all physical substance. Something was bound to give.
Hamid Ghaznavi
The Gazette of Medical Sciences, Volume 2, pp 35-43; https://doi.org/10.46766/thegms.radiology.21082006

Abstract:
To diagnose diseases during gestation period including renal stones, appendicitis, and pulmonary embolism in pregnant patients, computed tomography (CT) can be a golden standard. Due to CT examination, the fetus is prone to receiving a considerable dose which is the result of direct or scattered (external and internal scattered radiation) beams. The effects of ionization radiation on fetus include mutagenesis and carcinogenesis, therefore, it is essential to reduce fetus dose for pregnant patients who undergo CT examination during gestation period. This article aims to review approaches that are effective in reducing fetal dose in pregnant patients.
James A. Thorp, K. E. Thorp
The Gazette of Medical Sciences, Volume 2, pp 32-34; https://doi.org/10.46766/thegms.pubheal.21081005

Chahinez Houacine, Jaipaul Singh, Raphael Singh, Karishma Jeeboo, Abdullah Adil Ansari, Kamalinder K Singh, Emanuel Cummings
The Gazette of Medical Sciences, Volume 2, pp 16-29; https://doi.org/10.46766/thegms.pharma.21062806

Abstract:
Traditional medicines, derived from plants, could present alternative treatment strategy for cancer therapy. One such plant is Momordica charantia (MC) which possesses anti-carcinogenic properties. This study investigated the anticancer effect of an ethanol extract of MC fruit, Kuguacin-J (K-J), an isolated compound from the leaves of MC and cisplatin, either alone or combination on healthy MCF-10A mammary cells and compared with breast cancer MCF-7 and MDAMB-231 cell lines. Cell viability was tested using 8 μg/mL and 80 μg/mL doses of MC extract, K-J and cisplatin individually or combined for 24 and 48 hours. Caspase-3- activity was measured in MCF-7 and MDA-MB-231 cells using established methods. The results revealed that MC extract and K-J had no effect on healthy MCF-10A cell viability as compared to cisplatin which induced dose and time-dependent cell death. Similarly, treatment of MCF-7 cells with cisplatin induced cell death at high concentration at both the time points, while MC extract and K-J only induce MCF-7 cell death at high dose after 48 hours only. During combination therapy, both doses of cisplatin enhanced MCF-7 cell death when combined with MC extract or K-J after 24 and 48 hours. In MDAMB-231 cells, the three drugs, either alone or combined, evoked significant cell death at both the doses and time points. All three drugs, at high dose, elicited significant increase in caspase-3- activity in MCF-7 and MDA-MB-231 cells as compared to untreated cells. The results revealed that either MC extract or K-J alone or combined with cisplatin, can elicit significant increase in cell death and caspase–3-activity in MCF-7 and MDA-MB-231cells as compared to untreated cells.
James A. Thorp, K. E. Thorp, Emily K. Lile, John Viglione, Gulf Breeze Consultant
The Gazette of Medical Sciences, Volume 2, pp 1-15; https://doi.org/10.46766/thegms.pubheal.21071202

Abstract:
Introduction & Background: In recent months unexpected reports have surfaced claiming the presence of magnetic attraction in the shoulder regions of subjects who had recently received the COVID-19 vaccination. Purpose: To determine if such claims are legitimate or spurious. Methods: A prospective observational study was performed utilizing standard neodymium magnets and non-magnetized paper clips in a rigorously standardized application protocol. Magnets and paper clips were applied over various regions of both deltoid muscles. The attraction score was calculated by adding one point for each pole of the magnet that attached to each arm over the deltoid muscle for a maximum score of 4. Likewise, three sizes of paper clips were tested with a maximum score of 6. The field score was calculated by adding the magnet score to the paper clip score for a maximum score of 10 points
, Mohammad Saud Khan, Kevin John John, Ajay Kumar Mishra
The Gazette of Medical Sciences, Volume 2, pp 50-52; https://doi.org/10.46766/thegms.intmed.21062302

Abstract:
Interest in modulating the immune response beyond glucocorticoids has existed since the COVID-19 pandemic began. Recent trials have shown promising results with IL-6 inhibitors such as tocilizumab although similar data on Sarilumab is lacking. In this report, we analyze the current evidence on Sarilumab in hospitalized COVID-19 patients to evaluate its efficacy.
Juan Luis Delgado-Gallegos, Facultad de Medicina Universidad Autónoma de Nuevo León, Aurora de Jesus Garza-Juarez, Zuca G-Buentello, Jose Francisco Islas
The Gazette of Medical Sciences, Volume 2, pp 53-64; https://doi.org/10.46766/thegms.nufosci.21062404

Abstract:
Chronic degenerative diseases like obesity, metabolic syndrome, diabetes, fatty liver, have gained high prevalence in the world, due to sedentarism, improper nutritional habits as well as alcohol and tobacco consumption. Studies have shown that regular consumption of breakfast leads to a wide range of benefits, especially for the liver. The liver is a key organ for metabolic homeostasis regulating and governing energy metabolism, mostly providing nutrients for reabsorption. Benefits of a nutrimental quality breakfast seem to help lower body mass index, prevent metabolic diseases, and overall improve quality of life. Unfortunately, these include either high cholesterol or high-sugar foods including cold cuts, bread, eggs, and sugary beverages. Also, much of the population’s work schedule relates to long hours and high-level of stress, therefore malnutrition, and inadequate eating schedules are common.
Ahmad Mirza, Imran Gani, Ravi Mallavarapu, Laura Mulloy, Rajan Kapoor, Irfan Saeed
The Gazette of Medical Sciences, Volume 2, pp 46-49; https://doi.org/10.46766/thegms.surgery.21062403

Abstract:
Multi-organ procurement was performed on a 48-year-old donor after the patient was declared brain dead. A standard approach was performed for two dissections of abdominal organs. During the cold phase of dissection, an additional left sided retro-aortic vein was identified. The second vein had separate opening to the inferior vena cava in addition to the normal positioned pre-aortic left renal vein. Both veins were divided close to the origin from the inferior vena cava. During the back table preparation, it was noticed that same volume of preservative fluid was identified to be draining from both veins. Both veins were isolated and anastomosed separately on the 61-year-old recipient. Patient was initiated on anti-platelet therapy and made successful recovery.
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