Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

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Current Publisher: Faculty Opinions Ltd (10.3410)

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Jens-Michael Schröder, Wang C, Wang S, Li D, Wei Dq, Zhao J, Wang J
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, Volume 159; doi:10.3410/f.737998271.793579551

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Sharad Kumar, Jantina Manning, Manford Ag, Rodríguez-Pérez F, Shih Ky, Shi Z, Berdan Ca, Choe M, Titov Dv, Nomura Dk, et al.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, Volume 183; doi:10.3410/f.738676152.793579490

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Michael Symonds
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, Volume 396; doi:10.3410/f.738735164.793579491

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Achillefs Kapanidis, Kapadia N, El-Hajj Zw, Zheng H, Beattie Tr, Yu A, Reyes-Lamothe R
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, Volume 80; doi:10.3410/f.738646437.793579496

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Anthony Michael Carter, Thomas Jr, Appios A, Zhao X, Dutkiewicz R, Donde M, Lee Cyc, Naidu P, Lee C, Cerveira J, et al.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, Volume 218; doi:10.3410/f.738853234.793579497

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Neal Millar, Ilaltdinov Aw, Gong Y, Leong Dj, Gruson Ki, Zheng D, Fung Dt, Sun L, Sun Hb
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature; doi:10.3410/f.738091187.793579456

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Neal Millar, Dan M, Phillips A, Johnston Rv, Harris Ia
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, Volume 9; doi:10.3410/f.736655952.793579462

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Neal Millar, Kroslak M, Murrell Gac
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, Volume 46; doi:10.3410/f.732787982.793579463

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Wayne Koff
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature; doi:10.3410/f.738769194.793579435

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Wayne Koff, Tortorici Ma, Beltramello M, Lempp Fa, Pinto D, Dang Hv, Rosen Le, McCallum M, Bowen J, Minola A, et al.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature; doi:10.3410/f.738733832.793579440

Abstract:
Efficient therapeutic options are needed to control the spread of SARS-CoV-2 that has caused more than 922,000 fatalities as of September 13th, 2020. We report the isolation and characterization of two ultrapotent SARS-CoV-2 human neutralizing antibodies (S2E12 and S2M11) that protect hamsters against SARS-CoV-2 challenge. Cryo-electron microscopy structures show that S2E12 and S2M11 competitively block ACE2 attachment and that S2M11 also locks the spike in a closed conformation by recognition of a quaternary epitope spanning two adjacent receptor-binding domains. Cocktails including S2M11, S2E12 or the previously identified S309 antibody broadly neutralize a panel of circulating SARS-CoV-2 isolates and activate effector functions. Our results pave the way to implement antibody cocktails for prophylaxis or therapy, circumventing or limiting the emergence of viral escape mutants.Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).
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