International Journal of Clinical Case Reports and Reviews

Journal Information
EISSN : 2690-4861
Published by: Auctores (10.31579)
Total articles ≅ 170

Latest articles in this journal

Claudio Bazzi
International Journal of Clinical Case Reports and Reviews, Volume 11, pp 01-07;

Background: In glomerulonephritis (GN) with nephrotic syndrome (NS), proteinuric and novel molecular biomarkers do not achieve 100% accuracy in predicting outcome and treatment responsiveness. Aim of study: To verify whether the combined excretion of IgG/C and α2m/C, markers of damage to the epithelial cell layer (podocytes and slit diaphragm) of the glomerular filtration barrier (GFB) can assess disease severity, and predict outcome and responsiveness to steroids and cyclophosphamide. Methods: In 151 patients with glomerulonephritis and nephrotic syndrome a new proteinuric marker was developed based on a combination of different median values of urinary excretion of IgG/C and α2m/C: IgG/C < or > than the median was classified as IgG/C0 or IgG/C1, respectively. The median of α2m/C was calculated independently in IgG/C0 and IgG1, and classified as α2m/C0 and α2m/C1 if < or > than the median. Thus 4 groups were defined: IgG/C0 & α2m/C0, IgG/C0 & a2m/C1, IgG/C1 & α2m/C0, IgG/C1 & α2m/C1. Results: The groups from 1+1 to 0+0 are characterized by increasingly severe disease, with progressively higher eGFR and progressively lower histologic (GGS%, TID and AH scores) and proteinuric parameters (TUP/C, IgG/C, α2m/C and α1m/C). In 151 patients the functional outcomes rates were: IgG/C1&α2m/C1&BP 1: “Remission and persistent NRF”, 15%; “Progression and eGFR reduction”, 85%. In IgG/C0&α2m/C0&BP 0: “Remission and persistent NRF”, 96%; “Progression and eGFR reduction”, 4%. In 84 patients treated with steroids + cyclophosphamide: IgG/C1&α2m/C 1&BP 1: “Progression and eGFR reduction”, 100%: “Remission and persistent NRF”, 0%; IgG/C0&α2m/C0& BP 0: “Remission and persistent NRF”, 100%; “Progression and eGFR reduction”, 0%. Conclusions: Combined urinary excretion of IgG/C and α2m/C in association with blood pressure offers 100% prediction of outcome and responsiveness to steroid and cyclophosphamide treatment
Rajiv Kumar
International Journal of Clinical Case Reports and Reviews, Volume 11, pp 01-02;

Nanomaterials and nanotechnology are quite helpful in disease identification, prevention, treatment, scheming, and monitoring [4]. The properties of multifunctional nanomaterials altered by applying the strategies of nanotechnology and furnished for designing novel remedies for various medical applications. Furthermore, modified features of nanomaterials can influence their fate and also upgrade their claims in inhalation. Thus these types of nanoscale innovations achieved by adopting aforesaid strategies significantly. The nanotools and remedies treat viral infection and, in the end, also improve the health of the lungs
Kanika Chopra
International Journal of Clinical Case Reports and Reviews, Volume 11, pp 01-03;

Super-refractory status epilepticus is known as the seizure that persist beyond 24 hours even after administration of intravenous anesthesia drugs. It is a rare diagnosis especially in pregnant population and thus its management is also limited to case series and reports. Our case presented with this diagnosis and we managed it with three tier system of pharmacological agents and termination of pregnancy. Unfortunately, exact cause of the SRSE in our case was not found and patient has been discharged on dual antiepileptic drugs along with antidepressants with follow up in neurology out-patient department. It is important to keep one self-aware of the treatment protocol in cases of status epilepticus other than due to eclampsia.
Troise Stefania
International Journal of Clinical Case Reports and Reviews, Volume 11, pp 01-16;

Aim: Neurothekeoma is a benign lesion of superficial tissue mainly localized in the head-neck area. The aim of the article is to provide a systematic literature review on the tumor’s main characteristics and its correct surgical treatment. We support our theory with the report of an aggressive case of the lower lip region which required a large excision and reconstruction with local flaps. Materials and Methods: The literature review is based on the scientific materials produced from December 1980 to March 2020 on the head and neck neurothekeomas. In total, 76 papers were included in the study. We presented a classic neurothekeoma S-100 protein positive case that required wide local excision with healthy margins and reconstruction with Bengt-Johanson’s step technique. Results: Most of the papers were case reports (47,4 %) and reviews (19,7 %) with 721 evaluated neurothekeomas. The male to female ratio was 1:1,8 with a mean age of 26,4 years. The most frequent site of lesions was the head (36,1%), and the three subtypes were divided in cellular (65,7%) mixed (17,5%) and classic (16,8%). The classic neurothekeoma resulted more immunoreactive for S-100 Protein while cellular neurothekeomas for NKI/C3. Our case was successful without recurrence at 1 year follow-up. Conclusion: Our review highlights that neurothekeoma mainly occurs in young women in the superficial planes of the head and neck. The most frequent type is the cellular one, but the most aggressive is the classic type due to a high local recurrence of protein S-100. A local excision is sufficient for the cellular neurothekeoma, while for the classic type a wide local excision with healthy tissue margins is necessary. The treatment of our case demonstrates that by following this guide, relapse can be avoided.
Bandar Ali M.D
International Journal of Clinical Case Reports and Reviews, Volume 11, pp 01-05;

Acute Acalculous Cholecystitis “AAC” is defined by inflammation of the gallbladder without the presence of gallstones. It is by far less common than acute calculous cholecystitis where it only counts 5-10% of all cases of acute cholecystitis. In a patient with the disease of systemic lupus erythematous (SLE) having a gallbladder disorder is not common. Herein, we present a 43-year- old lady who is known case of hypertension, SLE, and End-stage renal disease on hemodialysis due to lupus nephritis presented to the emergency department with a right upper abdominal pain, and abdominal ultrasound revealed acalcular cholecystitis. Further diagnostic tools supported the diagnosis, and she underwent after preparation uneventful laparoscopic cholecystectomy (LC).
Kazumi Fujioka
International Journal of Clinical Case Reports and Reviews, Volume 10, pp 01-04;

The prevalence and incidence of non-alcoholic fatty liver disease (NAFLD) is increasing due to the epidemics of obesity and type 2 diabetes mellitus (T2DM). Many studies provided the evidence of the decreased flow-mediated vasodilation (FMD), increased carotid intima-media thickness (IMT), and increased brachial ankle pulse wave velocity (baPWV) in patients with NAFLD. Recently, a link between NAFLD and hypertension along with new genetic expression, ADIPOQ C11377G and AGTR1 has been shown. It is putative that NAFLD may induce systemic inflammation, insulin resistance, oxidative stress, and increased vasoconstriction and decreased vasodilation, subsequently leading to hypertension. Under the systemic inflammation, it has been suggested that NAFLD may promote sympathetic nervous system (SNS) and renin-angiotensin system (RAS) activation, and local vasculature and renal inflammation, subsequently leading to hypertension. The author has reviewed the current knowledge of the link between NAFLD and hypertension along with new genetic expression in this article. It plausible that NAFLD is a multisystem disease and is associated with hepatic and extrahepatic disease.
Emadia Alaki, Aziza Donques, Abdulwahab Al-Ayoubi, Ghannam Al –Ghannam, Abdul-Aziz Alsayegh
International Journal of Clinical Case Reports and Reviews, Volume 10, pp 01-08;

To describe the impact of the COVID-19 pandemic and lockdown on pediatric asthma housings and on disease burden in patients and their family. To study the effect of minimizing outdoor allergen exposure that done by the effect of lockdown and the compliance to give the inhalers because of availability of the parents in decreasing the bronchial asthma attacks. To improve clinical practice post COVID-19, not default to the past.
Fe Fernandez Hernandez
International Journal of Clinical Case Reports and Reviews, Volume 10, pp 01-04;

Introduction: The Medical Education development´s around the world appoint the real necessity to assume the most significant subject from the economic subjects related to the Public Health given that Economy is considered an important determining for the Public Health sector. Because of the previous reason, the health university managers must analyze the social context since an economic perspective. This process may identify the relation between the Public Health and its context for a better management from the health university manager. Objective: To describe the importance from the economic culture for the health university manager upping´s. Materials and methods: Was made a descriptive research from the importance from the economic culture for the health university manager upping´s. Were used the documental and the bibliographic research as empiric methods. Results: The economic culture defines a rational life style. That´s why is present in all persons from the society, including the medic educational managers. The human and the social development is conditioned and supported by the real available resources. Thus, the economic culture must be a practice and teoric reference for the medical educational manager for their efficient manager behavior. Conclusion: The economic culture is a main element from the whole continue and permanent formation of medic educational managers. This upping form contribute to a wholer formation for these managers close related to the human develop and the life quality. Then, the upping process around the economic culture for medic educational managers is an always present need for all health universities.
Farid Gharagozloo
International Journal of Clinical Case Reports and Reviews, Volume 10, pp 01-03;

Congenital absence of the left circumflex artery is a very rare congenital anomaly of the coronary arteries. Few cases have been reported in the literature. It is often an incidental finding following the request for cardiac imaging investigations due to the presence of chest pain of uncertain nature associated with a doubtful or positive stress test for suspected inducible ischemia. Consequently, computed tomography coronary angiography is the ideal diagnostic tool that is often used nowadays to confirm this suspicion and thus reliably diagnose this unique morphology. In this report the author describes the clinical case of a middle-aged patient with chest discomfort during effort followed by a positive cycle-ergometer Ex_ECG stress test for inducible myocardial ischemia.
Claribel Plain Pazos, Anel Pérez de Alejo Alemán, Luis Orlides Perdomo Rodríguez, Naidy Rojo Quintero, Anisbel Pérez De Alejo Plain, Yaquelin Herrera Cabello, José Raúl Ríos Medina
International Journal of Clinical Case Reports and Reviews, Volume 10, pp 01-04;

Aortic dissection is infrequent and affects mainly males. We present a 44-year-old male patient with a history of arterial hypertension who presented chest pain which was alleviated spontaneously, in the guardhouse a restless patient was seen, with pain in the upper abdomen, BP 170/100, saturation 98%, FC 100x´, FR 20x´, oliguria. Complementary tests were indicated and while the patient was on guard duty, he suffered sudden death. Aortic dissection is life threatening, an immediate diagnosis is essential, although in many cases it is carried out postmortem.
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