JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik

Journal Information
ISSN / EISSN : 1693-7899 / 2716-3814
Published by: Universitas Wahid Hasyim Semerang (10.31942)
Total articles ≅ 56
Filter:

Latest articles in this journal

Mar’Atus Sholikhah, Rahayu Apriyanti
JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 99-104; doi:10.31942/jiffk.v16i02.3233

Abstract:
Alpinia galanga (L.) Sw or galangal is widely used by Indonesian people as a spice in cooking. The content of catechins and 1-acetoxicavicol acetate in the extract is known to have antioxidant activity. The ability of these antioxidants needs to be applied to pharmaceutical dosage forms to improve aesthetics and ease of use. One of the topical drug delivery systems that is in accordance with the needs of the community today is the preparation of peel-off gel mask. The purpose of this study was to determine the effect of variations in PVA gelling agent concentration as a mask base on the physical characteristics of galangal extract peel-off gel masks. Three mask formulations were made based on variations in the concentration of PVA in the range of 5% -15%. The physical characterization of the preparations included organoleptic tests, homogeneity, pH, viscosity, adhesion, dispersion, and drying time. Homogeneity and organoleptic parameters were analyzed descriptively. The parameters of viscosity, drying time, pH, spreadability, and adhesion were analyzed statistically using Anova Single Factor with a confidence level of 95%. The results showed that the F1 and F2 formulas with PVA concentrations of 10% and 12.5% were the optimum formulas as a mask base. Based on statistical tests, variations in the concentration of PVA significantly influence the parameters of mask adhesion with a p-value of 0.0001 (
Fithri Zahara S, Ebta Narasukma A, Maria Caecilia N.S.H
JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 93-98; doi:10.31942/jiffk.v16i02.3232

Abstract:
Osteoarthritis (OA) is a degenerative joint illness characterized by cartilage destruction and often found on older people. The drugs commonly used to treat OA symptoms is paracetamol, nonsteroidal anti-inflammatory drugs (NSAIDs), food supplements such as glucosamine and chondroitin. The purposes of these studies are identifying the OA patient's characteristics (including gender and age), drug use evaluation based on the right patient, indication, and dose, as well as the potency of drug interactions on OA patients. This research is non-experimental research with a non-analytical descriptive design. The data was collected retrospectively with a purposive sampling method from outpatients OA medical records in RSUD Dr. M. Ashari Pemalang (March to April 2018 period). The results of this study indicate that patients have suffered OA for 1-2 years (40%), generally women (72.94%) with an age range of 46-55 years (39%). Most patients have an elementary school educational background (41%), and 43.53% of them are overweight (BMI 25.00-29.99). All medicines prescribed for OA patient therapy have been the right indication and patient. As many as 80.95% of the prescribed medicines had the right dose, and 19.05% of prescription drugs case categorized as underdosing. Drug interactions potency occurs in 30.58% of patients, with 29 cases. Keywords: Osteoarthritis, drugs use evaluation, outpatient
, Elya Zulfa, Dwara Andriani Astuti
JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 139-148; doi:10.31942/jiffk.v16i02.3239

Abstract:
The ethanol extract of guava leaves (EEGL) is proven to heal various types of wounds.This study aims to determine the physicochemical characteristics of the EEGL ointment with a hydrocarbon base formula and examine the effect of the ointment against cut wounds on wistar male rat. The EEGL was obtained by maceration using 70% ethanol solvent. The ointment made 3 formulas with a ratio of hydrocarbon base composition (cera alba:vaselin album) namely F1 (2.5:92.5)%; F2 (5:90)%; F3 (7.5:87.5)%. The physicochemical characteristics of all ointments examined included organoleptic, homogeneity, pH, viscosity, spreadability, and adhesion. Organoleptic, homogeneity and pH data were analyzed descriptively, while viscosity, spreadability and adhesion data were analyzedstatistically. Testing the effect of all ointment formulas on the wound was done by applying 0.5 gram 2x a day for 9 days compared to wound control without treatment and positive control used commercial product.The parameter of effect measured was the length of the cut wound on the 9th day, then analyzed with the Kruskall Wallis test followed by the Mann Whitney test.The physicochemical characteristics of EEGL ointment (F1, F2, F3) are known that all ointment formulas are brown in color, typical of guava, homogeneous, pH according to skin pH, viscosity and adhesion are significantly different, while the spredability is not significant.The EEGL ointment had an effect on the cut wound of the male wistar rats, ie the length of the wound on the 9th day was reduced and compared to wound controlwas differentsignificantly. Keywords :Guava leaves, ointment, cut of wound.
, Elya Zulfa, Listyana Dewi Prastiwi, Ikha Dyah Yulianti
JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 125-133; doi:10.31942/jiffk.v16i02.3237

Abstract:
The nanoparticle system encapsulates and protects flavonoids of suji leaves from photolysis and oxidation instability. Chitosan is a biocompatible, biodegradable and non-toxic nanoparticles forming polymer. Ultrasonication is a materials mixing technique under high vibration energy. The ultrasonication time affects the particle size. The aim of this study was to determine the effect of the ultrasonication time on physical characteristics of chitosan nanoparticles of suji (Pleomele angustifolia) leaf ethanol extract and its physical stability after cycling test. Ethanol extract of suji leaves (EEDS) was obtained by maceration using 70% ethanol. Chitosan EEDS nanoparticles were made under ionic gelation method using an ultrasonication time of 3 minutes (FI), 6 minutes (FII), and 9 minutes (FIII). The physical characterization of nanoparticles includes particle size, polydispersity index, and zeta potential. Chitosan EEDS nanoparticles with the best physical characteristics (FIII) were tested for stability using cycling test method. The data obtained were analyzed using the Anova statistical method with a 95% confidence level. The size of EEDS chitosan nanoparticles (nm) was significantly different in all formulas, FI (374.47), FII (288.43), and FIII (233.37). The polydispersity index of FI (0.38) and FIII (0.65) were significantly different, while FII (0.41) was not significantly different. The zeta potential (mV) FI (51.70), FII (46.10), and FIII (48.60) were not significantly different in all formulas. The physical characteristics of Formula III after Cycling Test showed a particle size of 455.0 nm, a polydispersity index of 0.174, and a zeta potential of 20.1 mV. Keywords: ultrasonication, nanoparticles, chitosan, cycling test, suji leaf (Pleomele angustifolia)
, Regina Andayani, Aulia Rahmi, Wida Ningsih
JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 134-138; doi:10.31942/jiffk.v16i02.3238

Abstract:
Whitening lotion is a mixture of chemicals or other ingredients with properties that can whiten the skin or blemish black (brown) on the skin. The use of mercury in whitening lotions can cause a variety of things, ranging from skin discoloration which can ultimately cause black spots on the skin, allergies and skin irritation. The using of mercury in high dose can cause permanent brain damageand cancer. An analysis of mercury content in the whitening lotion brands A, B and C circulating at market in Padang city has been conducted. Extraction of mercury in the whitening lotion was done by wet destruction with a concentrated HNO3 solution and concentrated H2SO4 for 2 hours at a temperature of ± 95°C until a clear solution is obtained. The clear solution was measured by absorption with an Atomic Absorption Spectrophotometer using a mercury hollow cathode lamp at a wavelength of 253.7 nm. The results of this study were samples of brands A, B and C detected containing mercury metals with successive levels of 0.3347 μg /g; 0,7917 μg /g and 0,7981 μg/ g. The whitening lotions that circulate in market do not meet the Head of BPOM RI Regulation No.18 of 2015 whose contents prohibit the use of mercury in cosmetics preparations. Keywords: mercury, whitening lotion, Atomic Absorption Spectrophotometer
, Dhia Salsabilla, Evi Sukawati
JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 105-110; doi:10.31942/jiffk.v16i02.3234

Abstract:
The chemicals contained in an extract must be maintained its quality. The aim of this study is to prove both that the ethanol extract of kecapi (Sandoricum koetjape, Merr.) and keluwih (Artocarpus communis) leaves meet the non-specific parameters on the standardization of the extract. The ethanol extract of kecapi and keluwih leaves were extracted using the ultrasonic method. The extract was tested with non-specific parameters including water content, total ash content and metal contamination level. The test results are compared with standard parameter references. Ethanol extract of kecapi leaf have water content of 27.75% ± 1.708, total ash content of 4.856% ± 0.040 and levels of As metal contamination < 0.030 mg/Kg, Hg < 0.002 mg/Kg, Pb < 0.400 mg/Kg, while ethanol extract of keluwih leaf have water content of 23.206 ± 0.091%, total ash content of 9,678 ± 0.306% and levels of heavy metal contamination of As < 0.03 mg/Kg, Hg < 0.006 mg/Kg, Pb < 0.02 mg/Kg. The both extract meet the standard parameters of water content, total ash content and levels heavy metal contamination. Key words: kecapi leaves (Sandoricum koetjape, Merr.), keluwih leaves (Artocarpus communis), non-specific standardization
Margareta Retno Priamsari, Rina Ayu Krismonikawati
JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 86-92; doi:10.31942/jiffk.v16i02.3231

Abstract:
Inflammation is a normal response to injury due to release of chemical mediators such as prostaglandins. Solanum betaceum Cav. skin contains flavonoid compounds. This study aims to determine the antiinflammatory power and the effect of variations in the dose of ethanolic extract of the skin of Solanum betaceum Cav on Swiss male strain mice caragenin-induced. The ethanolic extract of Solanum betaceum Cav skin was obtained using remaseration method with 96% ethanol solvent. Antiinflammatory power test using edema formation method with induction of caragenin 1% intraplantar 30 minutes before administration of the test material. Tests were carried out on 25 mice records which were divided into 5 groups namely negative control (0.5% CMC Na suspension), positive control (diclofenac sodium suspension in 0.5% CMC Na dose 7 mg/kgBW) and given suspension respectively. Dutch eggplant skin ethanolic extract in CMC Na 0.5% dose 70 mg/kgBW; 140 mg/kgBW; 280 mg/kgBW orally. The parameters observed were edema thickness measured using calipers at 30 minute intervals for 360 minutes. The results of edema thickness difference are used to calculate the Area Under Curve (AUC) and the percentage of antiinflammatory power (% AIP). Dat a were analyzed statistically with the One Way Anova test and continued by the Post Hoc Test with a 95% confidence level. The results showed that the ethanolic extract of Solanum betaceum Cav skin contains flavonoid compounds and has antiinflammatory power. The greater the dose of ethanolic extract of Solanum betaceum Cav skin, the greater the anti-inflammatory power. Keywords: Solanum betaceum Cav., antinflammation, caragenin
, Heru Fitranto, Yana Astiana, Mufrod Mufrod
JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 119-124; doi:10.31942/jiffk.v16i02.3236

Abstract:
Breadfruit leaves (Artocarpus altilis) was contain compound of flavonoids, tannins and phenol that the ability as antibacterial against Staphylococcus aureus bacteria. The extracts of breadfruit leaves formulated became ointment that made practice to used. The combine of ointment bases can obtain of good consistency like the combine of adeps lanae with vaselin album and cera flava with vaselin album. The aims of this study to know the profile of antibacterial activity of the breadfruit leaves extract ointment with two kind of the combine of ointment bases. The breadfruit leaves extract has obtained by maceration method used etanol 70% solvents. The breadfruit leaves ointment was made by melting method with combination bases A is adeps lanae:vaselin album as F1 (13.5%:76.5%), F2 (45%:45%) dan F3 (76.5%:13.5%), while combination B is cera alba:vaselin album as F1 (85.5%:4.5%), F2 (81%:9%), F3 (76.5%:13.5%). antibacterial activity assay was used well diffusion method and analyzed descriptively. The research result that the all formulas has breadfruit flavor, smooth texture and brown color. Two variatons of combination bases ointment has antibacterial activity against Staphylcoccus aureus bacteri with formed of inhibition zone around the well. Keywords: Breadfruit leaves extract, ointment, antibacterial, combination of ointment bases
Maria Mita Susanti, Syela Puspitaningtyas
JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 111-118; doi:10.31942/jiffk.v16i02.3235

Abstract:
The free radicals exposure from daily activities can cause the damage the skin, therefore to avoid this damage effect can use antioxidants compounds . Brown rice bran is rice milling waste which has high antioxidant with IC50 is 43,2349 ppm. Efforts to increase the economic value of rice bran high in antioxidant compounds is by processing rice bran into transparent soap products. This research was conducted to analyze the quality characteristics of transparent red rice bran soap (Oryza nivara) based on used cooking oil. The quality characteristics of transparent rice soap which includes organoleptic soap, pH, foam power, free alkali, and water content. The data were analyzed descriptively by comparing the results of research with SNI 06-3532 -1994 Based on the results of the study obtained the results of the characteristics of soap that meets the quality characteristics of SNI 06-3532-1994 soap requirements with a pH of 10,2 , foam power of 2,54 cm, free alkali of 0,034%, and 3,85% moisture content. Keywords : transparent soap, brown rice bran, used cooking oil, solid soap quality characteristics
Maria Mita Susanti, Syela Puspitaningtyas
JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 26-33; doi:10.31942/jiffk.v16i02.3124

Abstract:
The free radicals exposure from daily activities can cause the damage the skin, therefore to avoid this damage effect can use antioxidants compounds . Brown rice bran is rice milling waste which has high antioxidant with IC50 is 43,2349 ppm. Efforts to increase the economic value of rice bran high in antioxidant compounds is by processing rice bran into transparent soap products. This research was conducted to analyze the quality characteristics of transparent red rice bran soap (Oryza nivara) based on used cooking oil. The quality characteristics of transparent rice soap which includes organoleptic soap, pH, foam power, free alkali, and water content. The data were analyzed descriptively by comparing the results of research with SNI 06-3532 -1994 Based on the results of the study obtained the results of the characteristics of soap that meets the quality characteristics of SNI 06-3532-1994 soap requirements with a pH of 10,2 , foam power of 2,54 cm, free alkali of 0,034%, and 3,85% moisture content. Keywords : transparent soap, brown rice bran, used cooking oil, solid soap quality characteristics
Back to Top Top