Jurnal Ilmu Farmasi dan Farmasi Klinik

Journal Information
ISSN / EISSN : 1693-7899 / 2716-3814
Published by: Universitas Wahid Hasyim Semarang (10.31942)
Total articles ≅ 56
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Sri Haryanti, Zullies Ikawati, Mustofa Mustofa, Tri Murti Andayani
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 18, pp 8-15; https://doi.org/10.31942/jiffk.v18i01.4894

Abstract:
To produce an effect, the agonist drug 2 will bind to the ADRB2 receptor. The effect of agonist 2 shows variation between individuals due to the presence of encoding gene polymorphisms. There are 80 ADRB2 polymorphisms, including Arg16Gly in amino acids 16. The innate ADRB2 genotype is called wildtype, whereas mutated ones is called mutant. The purpose of this study was to determine whether there was a relationship between genotype rs 1042713 (Arg16Gly) and the effectiveness of β2-agonist drugs in asthma sufferers. This study was an observational study with a cross sectional design and prospective data collection. Examination of the presence of gene polymorphisms and assessment of effe A total of 101 asthma patients who met the inclusion criteria were sorted by genome type by pharmacogenomic examination uses the Asthma Control Test (ACT) questionnaire. The results of the statistical test with chi square to determine the relationship of genome type and asthma control obtained p value 0.131. The comparison of the effectiveness of the wildtype genome is more effective than the mutant of 1.887x, and heterozygote is more effective 1,667x greater than the mutant. There is no significant relation between genotypes rs 1042713 (Arg16Gly) with effectiveness, but the possibility of clinical effectiveness is different. Keywords: Asthma, β2-agonist, ADRB2, genotype, effectiveness.
Marwin Marwin, Dyah Aryani Perwitasari, Susan Fitri Candradewi, Bayu Prio Septiantoro, Fredrick Dermawan Purba
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 18, pp 16-23; https://doi.org/10.31942/jiffk.v18i01.4895

Abstract:
Breast cancer is the most common cancer found in women and is the dominant cancer in Indonesia. Cancer treatments such as chemotherapy can affect the quality of life of patients including physical, psychological, and social. The purpose of this study is to measure the quality of life of breast cancer patients. This research used cross sectional study design. The patient quality of life was measured using the EORTC QLQ-C30 questionnaire. The subjects of this study were breast cancer patients in RSUP Dr. Kariadi Semarang meeting the inclusion criteria. The cognitive function domain, social function, emotional function, role function, and physical function were 86,15 ± 17,82; 84,10 ± 21,13; 82,56 ± 17,72; 77,95 ± 29,77; 76,72 ± 22,95, respectively. Whereas in symptom scale group from pain, fatigue, insomnia, appetite loss, financial difficulties, nausea and vomiting, constipation, dyspnea and diarrhea were 32,82 ± 30,33; 32,65 ± 21,14; 31,79 ± 34,58; 31,79 ± 32,51; 30,77 ± 32,44; 23,59 ± 25,67; 17,95 ± 30,9; 4,62 ± 14,28; 4,10 ± 13,83, respectively. For global health status / quality of life obtained 72.18 ± 18.94. The highest score on the functional scale is the cognitive function domain and the lowest score is the physical function.On the scale of symptom the domain that has the highest score is the pain domain and the lowest score is the diarrhea domain. Keywords: quality of life, breast cancer, EORTC QLQ-C30
Weni Puspita, Heny Puspasari
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 18, pp 24-30; https://doi.org/10.31942/jiffk.v18i01.4896

Abstract:
Premna serratifolia L. leaves contain flavonoids, saponins, polyphenols, and terpenoids, potentially act as sunscreens. The purpose of this study was to determine the flavonoid content and SPF (Sun Protection Factor) ethanol extract of Premna serratifolia L. leaves from Melawi Regency, West Kalimantan Province using UV-Vis spectrophotometer. The Premna serratifolia L. leaves were extracted by maceration using 70% ethanol solvent, then the filtrate obtained was concentrated with a rotary vacuum evaporator to obtain a thick extract. The extract was determined for its flavonoid content using UV-Vis spectrophotometer at a wavelength of 439 nm, and the SPF value was determined at a concentration of 25, 50, 75, and 100 ppm with a UV-Vis spectrophotometer at a wavelength of 290-320 nm. The SPF value was calculated and analyzed descriptively using the Mansur method. The result showed that the average flavonoid content of ethanol extract of Premna serratifolia L. leaves was 3.70±0.02% calculated as quercetin. The SPF EEDB values obtained from variations in concentrations of 25, 50, 75, and 100 ppm respectively were 19.95±0.02; 30.08±0.01; 34.58±0.14; and 38.28 ± 0.12, where the SPF value is included in the ultra protection category. Key words: Premna serratifolia L. leaves, flavonoid content, SPF, UV-Vis Spectrophotometer
Pengantar Redaksi
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 18; https://doi.org/10.31942/jiffk.v18i01.4892

Abstract:
Assalamualaikum Wr.Wb Alhamdulillah seiring dengan perjalanan Fakultas Farmasi Universitas Wahid Hasyim Semarang, Jurnal Ilmu Farmasi dan Farmasi Klinik (JIFFK) telah memasuki tahun ke-17 semenjak penerbitan perdana tahun 2004. Kami tetap berharap bahwa JIFFK dapat memberikan kontribusi bagi perkembangan ilmu farmasi dan farmasi klinik. Kami berharap bahwa JIFFK ini dapat digunakan sebagai wadah bagi para peneliti, akademisi dan pemerhati ilmu farmasi dan farmasi klinik untuk mempublikasikan hasil penelitian atau pemikirannya. Demi menjaga eksistensi dan sustainabilitas JIFFK kami senantiasa memohon sumbangan tulisan atau artikel dari para peneliti. Kami selalu berusaha untuk dapat meningkatkan kualitas dari setiap penerbitan JIFFK ini, karena kami memiliki cita-cita supaya JIFFK dapat terakreditasi dari dikti. Akhir kata kami sampaikan terima kasih yang sebesar-besarnya kepada semua pihak yang telah membantu terlaksananya penerbitan ini. Kritik dan saran kami nantikan dari pembaca sekalian demi perbaikan dan kemajuan JIFFK. Wassalamu’alaikum Wr. Wb Semarang, Juni 2021 Hormat Kami Redaksi
Yance Anas, Ika Nilam Cahyani, Ulum Firnanda Sukma
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 18, pp 1-7; https://doi.org/10.31942/jiffk.v18i01.4893

Abstract:
Previous studies accomplished that the chayote ethanol extract (Sechium edule (Jack) Sw) had an antihypertensive effect. To get and identify the active compound, we fractionated the extract and evaluated its antihypertensive activity. This study aims to investigate the antihypertensive effect of the n-hexane fraction (HF-CEE) and ethyl acetate fraction of chayote ethanol extract (EAF-CEE) in monosodium glutamate (MSG)-induced hypertensive rats. We made the chayote extract using the maceration method by soaking the chayote simplicia in ethanol 70%. HF-CEE and EAF-CEE were obtained by stratified fractionation using n-hexane and ethyl acetate. An antihypertensive effect of the fraction measured on MSG-induced hypertension male Wistar rats after MSG 100 mg/kg BW/day (p.o) treatment for 14 days. The study concluded that HF-CEE and EAF-CEE had an antihypertensive effect in MSG-induced hypertensive rats. The EAF-CEE antihypertensive effect is higher than HF-CEE. Therefore, the FEAF-CEE active compounds need to be isolated, identified, developed, and their potential as an antihypertensive candidate. Keywords: Antihypertensive, chayote, ethyl-acetate fraction, Sechium edule, monosodium glutamate
Daftar Isi
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 18; https://doi.org/10.31942/jiffk.v18i01.4891

Abstract:
Jurnal Ilmu Farmasi & Farmasi Klinik Journal of Pharmaceutical Science & Clinical Pharmacy Pemimpin Umum/ Penanggung jawab Dekan Fakultas Farmasi Universitas Wahid Hasyim Pemimpin Redaksi Ketua Program Studi Farmasi Fakultas Farmasi Universitas Wahid Hasyim Dewan Penyunting Jurnal Dr. Yulias Ninik W., M.Si., Apt. Redaktur Ahli Dr. Ahmad Ainur Rofiq, M.Si., Apt. (Universitas Sebelas Maret), Burhan Ma’arif Zaenal Arifn, M.Farm. Apt. (UIN Maulana Malik Ibrahim), Dr. Isnaeni, M.S., Apt. (Universitas Airlangga), Kuni Zu’aimah Barikah, M.Farm., Apt. (Universitas Jember), Dr. Nurkhasanah, M.Si., Apt. (Universitas Ahmad Dahlan), Khoerul Anwar, M.Sc., Apt. (Universitas Lambung Mangkurat), Dr. Gunawan Pamudji Widodo, M.Si., Apt. (Universitas Setia Budi), Dr. Laela Hayu Nurani, M.Si., Apt. (Universitas Ahmad Dahlan), Dr. Iis Wahyuningsih, M.Si., Apt. (Universitas Ahmad Dahlan), Dr. Wahyu Widyaningsih, M.Si., Apt. (Universitas Ahmad Dahlan), Muhammad Ikhwan Rizki, M.Farm., Apt. (Universitas Lambung Mangkurat), Dr. Yulias Ninik W., M.Si., Apt. (Universitas Wahid Hasyim), Maulita Cut Nuria, M.Sc., Apt. (Universitas Wahid Hasyim), Yance Anas, M.Sc., Apt. (Universitas Wahid Hasyim), Risha Fillah Fithria, M.Sc., Apt. (Universitas Wahid Hasyim), Aqnes Budiarti, S.F..Sc., Apt. (Universitas Wahid Hasyim), Ririn Lispita Wulandari, M.Si.Med., Apt. (Universitas Wahid Hasyim), Maria Ulfah, M.Sc., Apt. (Universitas Wahid Hasyim), Elya Zulfa, M.Sc., Apt. (Universitas Wahid Hasyim), Anita Dwi Puspitasari, S.Si., M.Pd. (Universitas Wahid Hasyim), Dewi Andini Kunti Mulangsri, M.Farm., Apt. (Universitas Wahid Hasyim), Devi Nisa Hidayati, M.Sc., Apt (Universitas Wahid Hasyim), M. Fatchur Rochman, M.Farm. (Universitas Wahid Hasyim), Malinda Prihantini, M.Si., Apt. (Universitas Wahid Hasyim) Redaktur Pelaksana Elya Zulfa, S.Farm., M.Sc., Apt Staf Redaksi : Dewi Andini Kunti Mulangsri, M.Farm., Apt. Ririn Lispita W., S. Farm., M.Si.Med, Apt. Devi Nisa Hidayati, M.Sc., Apt Danang Novianto, S.Farm., Apt Erika Indah Safitri, M.Farm. Imam Asrofi, S.Farm. Distributor Fahmi Wildasani, A.Md Alamat Redaksi/Tata Usaha Fakultas Farmasi Universitas Wahid Hasyim Jl. Menoreh Tengah X/22 Sampangan Semarang Telp. 024-8505680, 8505681 Fax. 024-8505680 E-mail : [email protected] Terbit 2 kali setahun sejak September 2004
Septiana Laksmi Ramayani, Eka Amalia Permatasari, Indah Novitasari, Maryana Maryana
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 18, pp 40-46; https://doi.org/10.31942/jiffk.v18i01.4898

Abstract:
Excessive Reactive Oxygen Species (ROS) can cause hypertension. Prevention of the risk of hypertension is consume an antioxidant. Noni (Morinda citrifolia L). is a plant that empirically proven to lower blood pressure and has antioxidant activity. Antihypertensive activity of noni leaves is influenced by phenolic and flavonoid compounds. The extraction method affects the levels of compound in extracts. The aims of study is determine the effect of the extraction method on the total phenolic level, total flavonoid level and antioxidant activity of noni leaf extract. The extraction methods are maceration, Microwave Assisted Extraction and Soxhlet. The results showed that the different extraction methods affected the total phenol level, total flavonoid level and antioxidant activity of the noni leaf extract. The Soxlet method provides the highest total phenolic level, total flavonoid level and antioxidant activity than other extraction methods. Keywords: Noni leaf extract, extraction method, total phenolic level, total flavonoid level and antioxidant activity
Seri Agustini, Sari Wijayanti, Irma Novrianti
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 18, pp 31-39; https://doi.org/10.31942/jiffk.v18i01.4897

Abstract:
The plant that is believed by the public as a medicinal plant is Globe Amarant (Gomprena globosa L) which allegedly contains flavonoids and saponins compounds that can modulate wound healing acceleration. The flower has been shown to have an effect on wound healing in test animals, but so far there has been no research on the effectiveness of the knob flower on burns. Therefore, this study aims to identify the content of flavonoids and saponins in Kenop flowers and to see the effectiveness of healing burns in rabbits. The design of this study was an experimental study that used 5 groups of test animals, namely 2 control groups, and 3 groups of Kenop flower extract. Burn induction was performed using a 2x2 plate. The length of the wound was measured every 2 days using a caliper. Meanwhile, the identification test of flavonoid and saponin compounds was carried out using the forth and wilstatter methods. Based on the results of the study, it was found that the ethanol extract of the Kenop flower contains flavonoid and saponin compounds. The effectiveness test of the Knob flower extract on burns showed that the 30% extract group showed 92% wound healing with a wound diameter on the 14th day of 0.16; followed by a 20% extract group with a wound healing percentage of 84.3% with a wound diameter of 0.31 cm. The ethanol extract of the flower of the Kenop flower can heal burns at that concentration. Keywords: Kenop Flower, Flavonoids, Burns
, Elya Zulfa, Dwara Andriani Astuti
JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 139-148; https://doi.org/10.31942/jiffk.v16i02.3239

Abstract:
The ethanol extract of guava leaves (EEGL) is proven to heal various types of wounds.This study aims to determine the physicochemical characteristics of the EEGL ointment with a hydrocarbon base formula and examine the effect of the ointment against cut wounds on wistar male rat. The EEGL was obtained by maceration using 70% ethanol solvent. The ointment made 3 formulas with a ratio of hydrocarbon base composition (cera alba:vaselin album) namely F1 (2.5:92.5)%; F2 (5:90)%; F3 (7.5:87.5)%. The physicochemical characteristics of all ointments examined included organoleptic, homogeneity, pH, viscosity, spreadability, and adhesion. Organoleptic, homogeneity and pH data were analyzed descriptively, while viscosity, spreadability and adhesion data were analyzedstatistically. Testing the effect of all ointment formulas on the wound was done by applying 0.5 gram 2x a day for 9 days compared to wound control without treatment and positive control used commercial product.The parameter of effect measured was the length of the cut wound on the 9th day, then analyzed with the Kruskall Wallis test followed by the Mann Whitney test.The physicochemical characteristics of EEGL ointment (F1, F2, F3) are known that all ointment formulas are brown in color, typical of guava, homogeneous, pH according to skin pH, viscosity and adhesion are significantly different, while the spredability is not significant.The EEGL ointment had an effect on the cut wound of the male wistar rats, ie the length of the wound on the 9th day was reduced and compared to wound controlwas differentsignificantly. Keywords :Guava leaves, ointment, cut of wound.
, Elya Zulfa, Listyana Dewi Prastiwi, Ikha Dyah Yulianti
JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 125-133; https://doi.org/10.31942/jiffk.v16i02.3237

Abstract:
The nanoparticle system encapsulates and protects flavonoids of suji leaves from photolysis and oxidation instability. Chitosan is a biocompatible, biodegradable and non-toxic nanoparticles forming polymer. Ultrasonication is a materials mixing technique under high vibration energy. The ultrasonication time affects the particle size. The aim of this study was to determine the effect of the ultrasonication time on physical characteristics of chitosan nanoparticles of suji (Pleomele angustifolia) leaf ethanol extract and its physical stability after cycling test. Ethanol extract of suji leaves (EEDS) was obtained by maceration using 70% ethanol. Chitosan EEDS nanoparticles were made under ionic gelation method using an ultrasonication time of 3 minutes (FI), 6 minutes (FII), and 9 minutes (FIII). The physical characterization of nanoparticles includes particle size, polydispersity index, and zeta potential. Chitosan EEDS nanoparticles with the best physical characteristics (FIII) were tested for stability using cycling test method. The data obtained were analyzed using the Anova statistical method with a 95% confidence level. The size of EEDS chitosan nanoparticles (nm) was significantly different in all formulas, FI (374.47), FII (288.43), and FIII (233.37). The polydispersity index of FI (0.38) and FIII (0.65) were significantly different, while FII (0.41) was not significantly different. The zeta potential (mV) FI (51.70), FII (46.10), and FIII (48.60) were not significantly different in all formulas. The physical characteristics of Formula III after Cycling Test showed a particle size of 455.0 nm, a polydispersity index of 0.174, and a zeta potential of 20.1 mV. Keywords: ultrasonication, nanoparticles, chitosan, cycling test, suji leaf (Pleomele angustifolia)
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