JFL : Jurnal Farmasi Lampung

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ISSN / EISSN : 2355-2506 / 2598-4896
Published by: Wahana Peternakan (10.37090)
Total articles ≅ 60
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Nofita Nofita, Universitas Malahayati Bandar Lampung Program Studi Farmasi
Published: 28 September 2021
JFL : Jurnal Farmasi Lampung, Volume 10, pp 62-70; https://doi.org/10.37090/jfl.v10i1.496

Abstract:
Dayak onion (Eleutherine polmifolia (L.) Merr) was a typical plant of Kalimantan. Empirically dayak onion (Eleutherine polmifolia (L.) Merr) used by the comunity to treat skin infections. The purpose of this study was to determine the antibacterial activity of ethanol extract of dayak onion power against Salmonella typhi and Escherichia coli bacteria. The highest concentration used was 100%, and the lowest concentration was 0,5%. As a control of cloramfenikol for Salmonella typhi and ciprofloxacin for Escherichia coli bacteria. This research method used agar diffusion. The results showed the ethanol extract of dayak onion (Eleutherine polmifolia (L.) Merr) contained flavonoids, alkaloids, tannins and phenols with the highest levels was by tannins at 7,45%. Dayak onion (Eleutherine polmifolia (L.) Merr) are inhibiting the growth of Salmonella typhi bacteria at a minimum inhibitory concentration (MIC)of 1% with a inhibition zone diameter of 6,24 mm and 0,9% with a inhibition zone diameter of 6,20 mm at Escherichia coli bacteria.Keywords : Eleutherine polmifolia (L.) Merr, Salmonella typhi, Escherichia coli, Agar diffusion, MIC
Universitas Tulang Bawang Lampung Program Studi Farmasi, Samsuar, Akhmad Rokiban, Adityo Hartono, Ratna Setianingsih
Published: 28 September 2021
JFL : Jurnal Farmasi Lampung, Volume 10, pp 71-81; https://doi.org/10.37090/jfl.v10i1.497

Abstract:
Research on the isolation of terpenoid class of compounds from the seeds of papaya (Carica papaya L.) and test its activity against Staphylococcus aureus in vivo in male rabbits. This research aims to prove that the terpenoid compounds isolated from the seeds of papaya (Carica papaya L.) can inhibit the growth of Staphylococcus aureus in vivo. Separation of terpenoid compounds by column chromatography ((eluent n-hexane: ethyl acetate: ethanol)) resulted in 25 eluates, and then merged based on the results of identification by TLC ((nhexane: ethyl acetate (8: 2)) and the color test reagent Lieburmann -Burchard produce 5 fraction groups. fraction D showed positive terpenoids with Rf 0.75 and the color purple with Lieburmann-Burchard reagent. study using 15 rabbits were divided into 5 groups: P1 (negative control), P2 (positive control) , P3 (5% of the test group), P4 (10% of the test group), P5 (test group 15%). each group was given the intracutaneous Staphylococcus aureus as 0,2ml on the backs of rabbits. Having symptoms of infection each group was given the test substance 3 times a day topically, the observed parameter is the diameter of the wound, and histopathological observations performed on days 3,6 and 9 Analysis of the results of research conducted using ANSIRA showed highly significant differences between groups (p <0.05). Then proceed with the analysis of the results of the analysis HSD test showed highly significant differences in the test group 5% to 10% of the test group and the test group 15%. Isolates terpenoid class of compounds from the seeds of papaya (Carica Papaya L.) with a concentration of 10% and 15% can inhibit the growth of Staphylococcus aureus. Keywords: Antibacterial, Staphylococcus aureus, male rabbits
Lilik Koernia Wahidah, Universitas Tulang Bawang Lampung Program Studi Farmasi, Novita Tri Wahyuni, Hijrah, Miftahul Choiriah
Published: 28 September 2021
JFL : Jurnal Farmasi Lampung, Volume 10, pp 16-24; https://doi.org/10.37090/jfl.v10i1.493

Abstract:
Hypertension is a condition in which systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg. Hypertension is often found in geriatrics that can affect the onslence of heart disease and blood vessels. Increased cases of hypertension, the rational use of drugs by hypertensive patients is one of the important elements in achieving health quality. The purpose of this study is to find out the harsh use of antihypertensive drugs in outpatient geriatric patients at Dr. A. Dadi Tjokrodipo Hospital bandar Lampung. This type of research is non experimental with a descriptive design using retrospective data with purposive sampling methods. The results of the study were based on the pattern of use of antihypertensive with the ATC/DDD method in hypertension patients in Dr. A. Dadi Tjokrodipo Bandar Lampung city is 5331,03 DDD/1000 KPRJ, there are nine types of antihypertensive used, namely amlodipine, lisinopril, candesartan, irbesartan, furosemide, spironolactone, ramipril, bisoprolol and captopril. Antihypertensive in the drug uses segment 90%, namely amlodipine 44.37%, lisinopril 16.88%, candesartan 15.46% and irbesartan 13.65%. The study was based on 100% patient accuracy criteria, 100% indication accuracy, 89.3% drug accuracy and 92% dose accuracy. The conclusion of this study, the pattern of use of antihypertensive widely used is amlodipine amounting to 2365.52 DDD/1000 KPRJ, antihypertensive that enters the drug uses segment 90% namely amlodipine, lisinopril, candesartan and irbesartan.Keywords: Antihypertensive, Geriatrics, Outpatient, Drug Use
Arsy Fauziah, Isna Mulyani, Rizki Nisfi Ramdhini
JFL : Jurnal Farmasi Lampung, Volume 10, pp 1-10; https://doi.org/10.37090/10.37090/jfl.v9i1.325

Abstract:
Oksidasi bisa terjadi bukan hanya pada kulit saja melainkan rambut juga bisa mengalamiproses oksidasi. Paparan sinar UV-A, UV-B, polutan dan bahan kimia yang digunakanpada rambut berpotensi untuk menyebabkan oksidasi. Antosianin diketahui memiliki efekantioksidan karena merupakan senyawa turunan flavonoid. Penelitian ini bertujuan untukmengembangkan formula sampo yang mengandung ekstrak ubi jalar ungu sebagaisumber antioksidan. Formula dibuat dengan menggunakan bahan natrium lauril sulfat,NaCl, propilen glikol, metil dan rpopil paraben dan ekstrak ubi jalar ungu. Optimasi sediaanhanya dilakukan pada variasi konsentrasi NaCl sebagai peningkat viskositas di konsentrasi2%, 3% dan 4%. Evaluasi sediaan meliputi uji organoleptik, pH, bobot jenis, dayapembersihan, tinggi dan stabilitas busa. Sediaan memiliki pH yang memenuhi rentangpersyaratan sediaan maupun stabilitas antosianin. Perbandingan tinggi busa pada waktu20 menit terhadap waktu 1 menit yang dihasilkan oleh formula 1,2,3 berturut-turut 1 ; 0,8dan 0,5. Bobot jenis yang dihasilkan sediaan pada formula 1, 2, 3 secara berturut-turutadalah 1,0409 ; 1,1 dan 1,116 . Sampo dengan formula 2 yang dengan variasi NaCl padakonsentrasi 3% secara aplikasi paling nyaman untuk digunakan karena memilikikekentalan paling sesuai.Kata Kunci: Sampo antioksidan, ubi jalar, antosianin.
Yuli Wahyu Tri Mulyani, Akhmad Rokiban, Galih Cipto Mahendra
JFL : Jurnal Farmasi Lampung, Volume 10, pp 10-15; https://doi.org/10.37090/jfl.v10i1.492

Abstract:
Yellow kepok banana peel (Musa balbisiana) contains antibacterial compounds against S. epidermidis, S. aureus and P.acne. This study aims to proved the antibacterial activity of the yellow kepok banana peel extract fractionated using ethanol as a solvent against S.epidermidis, S.aureus and P.acne. The yellow kepok banana peel extraction process was carried out by maceration method with 70% ethanol followed by fractionation to obtain ethanol fraction. Antibacterial activity testing using nutrient agar (NA) media with wells method with a concentration of 25,000 ppm, 50,000 ppm, 100,000 ppm, aquadest as a negative control and clindamycin as a positive control. The phytochemical test of the ethanol fraction showed the content of alkaloids, flavonoids, saponins, tannins and quinones. The results of the inhibition zone diameter of the ethanol fraction at a concentration of 100,000 ppm against S. epidermidis (11.87 mm), S. aureus (12.04 mm) and P. acne (11.35 mm). The test is to determined the minimum inhibitory concentration (MIC) the minimum inhibitory concentration value of the ethanol fraction of S. epidermidis, S. aureus is 20,000 ppm and for P. acne is 17,500 ppm. The conclusion of this studied was that the ethanol fraction of kepok yellow banana peel extract has inhibitory and bacteriostatic properties against S. epidermidis, S. aureus and P.acne bacteria.Keywords: alkaloids,Ant ibacter ial , flavonoids , Fractionated, Musa balbisiana
Winda Trisna Wulandari, Gina Nur Fitria Mulyana Putri, Hisni Nurul Fajri, Indah Alvina Damayanti, Silvia Rahmawati, Dina Lestari
JFL : Jurnal Farmasi Lampung, Volume 10, pp 25-53; https://doi.org/10.37090/jfl.v10i1.494

Abstract:
COVID-19 (Coronavirus Disease-2019) is an infectious disease caused by the acute respiratory syndrome SARS-CoV-2. Currently, the COVID-19 disease outbreak is experienced by various countries around the world, including Indonesia. In overcoming it, there are several ways of deterrence that can be done, such as by increasing the body's immunity. During the COVID-19 pandemic, maintaining immunity is something that needs to be considered. In addition to vitamins, herbal plants that have the potential as immunomodulators can also be consumed. Therefore, through efforts to improve theimmune system, this review aims to obtain plants that have the potential as immunomodulators to enhance the immune system during the COVID-19 pandemic. The research method in the review used journals available online at Google Scholar with Sinta or Garuda accredited journals. The main focus of this review is herbal plants that have a role as an immunomodulator that can improve the body's immune system. The journals used are journals published in 2011-2021 with inclusion criteria, namely using Indonesian or English about plants that have the potential as immunomodulators, then the journalsobtained are analyzed. The results obtained were 30 types of plants that have potential as immune system enhancers including Dayak Onion Tubers, Papaya Leaves, Kecombrang Fruits, Pineapple Fruits, Kesambi, Soursop Leaves, Purslane, Garlic, Dates, Celery Leaves, Andaliman, Mahkota Dewa Fruit. , Moringa, Meniran, Noni Fruit, Gotu Kola, Sambiloto, Kiseureuh, Javanese Chili, Tempuyung Leaves, Basil Leaves, Ceplukan, Seaweed, Neem Leaves, Red Betel Leaf, Salam Leaves, Guava, Turmeric, Lime and Red Ginger Rhizome with compounds that act as flavonoids, alkaloids, saponins, triterpenoids,xeronin, tannins, quersentin, -tocopherol, lycopene, catechins, diterpenoids, deoxyandrographolide, andrographolide, epicatechin isothiocyanate and curcumin. Keywords: COVID-19, Potency of Immumodulator Plants, Flavonoids
Isna Mulyani, Rizki Nisfi Ramdhini, Syaikhul Aziz
JFL : Jurnal Farmasi Lampung, Volume 10, pp 54-61; https://doi.org/10.37090/jfl.v10i1.495

Abstract:
Kepok banana peel is an organic waste that has potential to be reused. Several studies proofed that banana peels have antioxidant activity, antimicrobial, inhibit the formation of cholesterol crystals and gallstones, diuretic effect, and mutagenic effect. This study aims to identify secondary metabolites contained in kepok banana peels using qualitative test methods (phytochemical screening) and thin layer chromatography analysis. The results of the phytochemical screening of kepok banana peel indicated the presence of alkaloids, monoterpenes/sesquiterpenes, phenols/tannins, saponins,and quinones. Thin layer chromatographic profile of ethanol extract showed the presence of flavonoid, phenol, and quinone compounds.Keywords: Phytochemical, chromatography, banana peel
Rizki Nisfi Ramdhini, Isna Mulyani, Syaikhul Aziz
JFL : Jurnal Farmasi Lampung, Volume 10, pp 82-91; https://doi.org/10.37090/jfl.v10i1.498

Abstract:
Peanut peel are a waste product of the peanut processing industry with little commercial value. Some of studies have been conducted indicating peanut peel can be beneficial as a source for traditional medicinal products since it is also rich of antioxidants. The aim of this research was to identify the content of secondary metabolites on the peanut peel. The method used was maseration with 96% ethanol. Phytochemical screening and assaying were performed using thin layer chromatography (TLC) method. The results of TLC analysis showed that the secondary metabolites in peanut peel were positive for flavonoids, alkaloids, tannins and quinon. Keywords: Peanut peel, Phytochemical, Thin-Layer chromatography (TLC)
Ramadhan Triyandi, Fakultas Kedokteran Program Studi Farmasi Universitas Lampung, Akhmad Rokiban, Catur Setia Pratiwi Ms, Fakultas Mipa Jurusan Farmasi
JFL : Jurnal Farmasi Lampung, Volume 9, pp 1-9; https://doi.org/10.37090/jfl.v9i1.325

Abstract:
This study aims to determine the anti-inflammatory effect of the water extract of Daun wungu (Graptophyllum pictum L.) extract which was observed from the decrease in the volume of edema of rat’s feet which was induced by 1 % carrageenan as much as 0,1 ml, was carried out in 25 male white rats divided into 5 groups. Negative controlwas given distilled water given 5 % Na CMC, diclofenac sodium as a positive control with a dose of 0,9 mg/200 g BB and water fraction of wungu leaf extract with a dose 1 (1,125 mg/kg bb), dose 2 (2,25 mg/kg bb) dan dose 3 (4,5 mg/kg bb). The measurement of edema volume is carried out every hour for six hours after induced carrageenan. From the results of testing the water fraction of wungu leaf extract, % inhibition showed that the dose group 3 (4,5 mg/kg bb) had anti-inflammatory activity that was comparable to the positive control group. Of all dosage variatons in this study the effective dose which has the highest percentage of edema is the dose 3 (4,5 mg/kg bb). Based on the results of statistical analysis, the percentage of edema inhibition data on the water fraction of wungu lear extract from all dose variations showed significant differences with negative controls. Keyword : Graptophyllum pictum L Anti-Inflamasi
Resna Sari Asih, Program Studi Farmasi Stikes Bakti Tunas Husada, Ilham Alifiar, Yedy Purwandy
JFL : Jurnal Farmasi Lampung, Volume 9, pp 78-83; https://doi.org/10.37090/jfl.v9i2.335

Abstract:
Chronopharmacology is a therapy based on circadian rhythms that can be said to be relevant if the risk and symptoms of the disease are predicted to vary over time. This study aims to determine the effect of chronopharmacology on total cholesterol and triglyceride levels in the blood of patients with fibrates and statin groups, so that patients with certain diseases are encouraged to take drugs according to the organ picket hours or circadian rhythms. This study was an observational descriptive study with a cross sectional study design involving 18 patients. Primary data were obtained through interviews and checking total cholesterol and triglyceride levels while secondary data were obtained from the patient's medical record. Based on the results of the analysis using SPSS for statin drug use in the morning and at night getting a value of P = 0.003. whereas for drug use in the fibrat group in the morning and evening, P = 0.083 was obtained. Based on the results of the research that has been done, it can be concluded from 18 patients using statins and fibrates in RSUD Dr. Soekardjo Tasikmlaya, for the use of statin drugs at night is more beneficial, but in the use of fibrates in the morning or evening the same effectiveness. Keyword : chronopharmacology, statin, fibrat
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