INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH
Latest articles in this journal
INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH pp 4-6; https://doi.org/10.36106/ijsr/0705552
Thrombotic thrombocytopenic purpura is a haematological disorder which affects the arterioles and capillaries of multiple organs.We report three cases of TTP successfully treated with plasmapheresis & low dosage rituximab.All three cases were diagnosed according to diagnostic criteria of TTP.A Weekly doses of 100 mg rituximab was given for four week(on day 1,day 8, day15 ,day22).Resolution of clinical symptoms and hemotological abnormalities after completion of treatment, all three patient achieved complete Response. The duration of complete response was 5-27 months. During the treatment course, All three patients were treated with plasmapheresis at different times, the recommended quantity of 9 plasmapheresis was 40 ml/kg once a day and the plasmapheresis was stopped when platelet dose went up to 150x10 . This case series indicates that plasmapheresis may positively support early salvage therapy in both acute/refractory and relapsing cases and its combination with rituximab exhibits short and long term favorable effects for the treatment of TTP.
INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH pp 28-29; https://doi.org/10.36106/ijsr/6703505
Lhermitte-Duclos disease (LDD) arises from an uncommon benign lesion which alters the normal cerebellar laminar pattern. This case report shows the imaging ndings of this condition in 39 year-old male, presented with history of headache and dizziness for duration of ten days. Intial assessment included a non-contrast CT which showed a mass in left cerebellar hemisphere with surrounding mass effect. MRI multiplanar sequences showed a well dened T2 hyperintense lesion with a tigroid appearance.The lesion showed a mild bright signal on diffusion-weighted images, whereas MR Spectroscopy shows reduced choline levels. Differential diagnosis in terms of imaging include subacute infarct, cerebellitis, glial tumor,encephalitis but these do not give the classical tigroid appearance on MRI. Lack of contrast enhancement , signicant diffusion and cellularity of the lesions can help in differentiating among them.
INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH pp 74-75; https://doi.org/10.36106/ijsr/7805004
Infertility is known to distress humanity since time is known. It does not merely affect the female or her spouse rather impacts signicantly the family as a whole. Its suffering is very stressful and even leads to a morbid mental health issue of- depression, anxiety, aggression, phobia, sexual dysfunction, dissociation and sleep disturbances. The medical management of these issues further complicates the picture with drug-related sexual side effects. Also, there is a signicant psychological and social dysfunction associated with infertility. Thus, Infertility is a multifactorial disease that needs comprehensive multidisciplinary management and care.
INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH pp 60-61; https://doi.org/10.36106/ijsr/1901806
To evaluate and compare the diagnostic accuracy of detecting malignant cervical lymph nodes using Clinical evaluation, CT scan and Ultrasonography and conrmation with histopathology in patients with squamous cell carcinoma. Atotal number of 30 patients, of both sexes, with carcinoma of different regions of the oral cavity, conrmed with incisional biopsy were included in this study. We found USG to be most sensitive (83.5%), followed by CT (78.3%) and clinical evaluation (63.7%). Similarly, CT scan was found to be most specic (81.5%), followed by USG (78.2%) and clinical evaluation (60.7%).
INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH pp 13-14; https://doi.org/10.36106/ijsr/4205859
Objective:- This study was planned to estimate the level of Serum Malondialdehyde (MDA) and Vitamin E in patients with senile cataracts and compare these with healthy controls. Methodology:-Atotal number of 100 pre-diagnosed senile cataract cases and 100 controls of age group 45 to 70 years were included in the study. Statistical analysis was done using t-test. Signicance was set at p < 0.05. Results:- Signicantly increased levels of serum lipid peroxide in the form of Malondialdehyde (MDA) (p<0.0001) were observed in the cataract patients as compared to the controls. Signicantly decreased levels of Vitamin E (p<0.0001) were observed in all the patients. Conclusion:- This suggests that oxidative stress and reduced antioxidant defense mechanism play an important role in the pathogenesis of Senile cataract which needs further studies
INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH pp 19-21; https://doi.org/10.36106/ijsr/1906106
Background:The rate of success of a physiotherapy treatment programme is strongly inuenced by the adherence of the patient with prescribed treatment programme. Non-adherence with the therapy given to the patient is often overlooked and is one of the reasons for failure to achieve desired results aimed for a given disease/condition. Methods:Atotal of 40 geriatric subjects (20 urban and 20 rural) were surveyed for information using self-questionnaire from Rohtak district. Results: Out of 40 subjects (10 urban males and 10 urban females and 10 rural males and 10 rural females) 70% of urban (30% females and 40% males) and 30% of rural (10% females and 20% males) population was found to be adherent to physical therapy treatment. Impediments identied in the current study that were statistically signicantly associated with non-adherence to physical therapy treatment among the geriatric population included residential locality (p=0.02), accessibility to physiotherapy clinics (p=0.001), paying capacity (p=0.003), compliance to unsupervised home based exercise treatment (p=0.01) and cooperation by family members (p= 0.01). A non-signicant relationship was found with ability of doing ADLs (p=0.06). Conclusion: The study shows that geriatric population of Rohtak district residing in urban areas are more adherent to physical therapy treatment programme as compared to those residing in rural areas.
INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH pp 71-72; https://doi.org/10.36106/ijsr/4508031
Dandy-Walker malformation (DWM) or syndrome is a posterior fossa anomaly characterized by agenesis or hypoplasia of the vermis and cystic enlargement of the fourth ventricle causing upward displacement of tentorium and torcula. Most patients have hydrocephalus at the time of diagnosis. DMW is the most common posterior fossa malformation, and it typically occurs sporadically. This is a case report of male fetus that was diagnosed to have Dandy Walker Malformation during the antenatal obstetric scans.
INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH pp 51-52; https://doi.org/10.36106/ijsr/7304331
SARS Cov-2 is a new strain of coronavirus that’s appeared at the last quarter of 2019 in China. Malaria is an communicable disease caused by Plasmodium protozoa that is transmitted through a mosquitoes bite it is severe and fatal disease if not properly diagnosed and appropriately managed. Here we present the case of 39 years old male patient was attended to the outpatient department of internal medicine in tertiary care hospital in Hyderabad with chief complains of fever, chills, body pains. After all investigations she was diagnosed with SARS Cov-2 Positive. But after using all appropriate medications, there was no improvement in the patient condition. Then she was underwent for other investigations in that she was diagnosed with malaria disease. After using proper combination of anti-malarial medications, symptoms were subsided gradually or completely resolved.
INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH pp 24-25; https://doi.org/10.36106/ijsr/0306321
Despite of advances in surgical techniques and adjuvant chemotherapeutic regimens, colorectal cancer remains one of the major leading causes of deaths worldwide. Histopathology is an important factor in the treatment and prognosis of cancer. The purpose of this study was to describe the different histopathological pattern in colorectal cancer. 81 cases of colorectal carcinoma received in pathology department over a period of four years were included in the study. The surgical specimen and colonoscopic biopsies' gross features were noted and samples were stained with Haematoxylin and Eosin. Detailed microscopic examination of tumor with lymph node status was done followed by histological typing. Grading of the tumor, age and sex distribution of cases were also noted. The commonest histopathological nding was adenocarcinoma 75.32% followed by mucinous adenocarcinoma 9.88% and signet ring cell carcinoma 8.64%. Among 61 cases of adenocarcinoma most commonly moderately differentiated adenocarcinoma 60.66% was noted.
INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH pp 55-59; https://doi.org/10.36106/ijsr/2604593
Background: Ghrelin and leptin are the key hormones involved in the energy homeostasis and plays a relevant role in regulating hunger and satiety stimuli afferent to the brain. Abnormalities in the levels of ghrelin and leptin are often associated with the obesity and type 2 diabetes complications. However, there are no studies clarifying whether ghrelin and leptin levels have stronger association with obesity or Type 2 diabetes (T2DM). Aims:To evaluate and compare the independent effect of major dening factors of obesity and diabetes on ghrelin and leptin concentrations. Materials And Methods: Anthropometric measures such as height, weight, waist (WC) and hip circumference (HC), Body mass index (BMI), Basal metabolic rate (BMR), fat percentage, lean body mass, were taken. Assessed daily physical activity and energy intake. Biochemical parameters such as fasting glucose, postprandial glucose, HBA1c, ghrelin, leptin and insulin levels were measured. Statistical Analysis: One-way analysis of variance (ANOVA), Chi-square (χ2) test Pearson's correlation coefcients, Multiple stepwise linear regression model analysis were performed. Result: The diabetic subjects irrespective of obesity showed signicantly higher waist to hip ratio, HOMAIR levels of fasting blood glucose, postprandial glucose and signicantly lower levels of Ghrelin than non-diabetics. Similarly, obese subjects irrespective of diabetes have signicantly higher BMR and higher levels of Leptin than non-diabetics. Asignicantly higher BMI, fat mass percentage and lower lean body mass percentage were observed in obese subjects irrespective of diabetes than non-obese subjects. Among non-obese, diabetics have higher BMI, Fat mass percentage and lower lean body mass percentage. The levels of insulin were signicantly higher in diabetic obese subjects. HOMAIR (P≤0.0001) and Postprandial glucose (P≤0.05) showed negative independent effect and QUICKI (P≤0.0001) showed positive independent effect on the levels of ghrelin. BMI (P≤0.05) showed a positive effect and lean body mass percentage (P≤0.0001) showed an inverse effect on levels of leptin. Conclusion: It is evident from the study that low levels of ghrelin are predominantly associated with diabetes parameters when compared to parameters of obesity and on the contrary increased leptin levels have much stronger association with measures of obesity than diabetes. Evidence of altered leptin and ghrelin levels in these disorders infers vice versa, their respective roles in obesity and lean diabetes.