Journal of Integrative Medicine

Journal Information
EISSN : 2315-4616
Published by: Bilingual Publishing Co. (10.30564)
Total articles ≅ 39
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, Min Jo Kim, Hyun Ah Jung, Jae Sue Choi, Jin Pyeong Jeon, Takako Yokozawa
Journal of Integrative Medicine, Volume 10; https://doi.org/10.30564/jim.v10i2.3441

Abstract:
Inhibition of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) or glycogen synthase kinase-3β (GSK-3β) is estimated to be the central therapeutic approach for Alzheimer’s disease (AD). In this study, water extract of Kangenkaryu, its crude drug and chemical composition used in oriental medicine were evaluated regarding their BACE1 and GSK-3β inhibitory activities.Fluorescence resonance energy transfer was used to characterize the BACE1 inhibitory effect of Kangen-karyu, its crude drug and chemical composition.GSK-3β activity was determined using the Kinase-Glo Luminescent Kinase Assay Platform. The water extract of Kangen-karyu inhibited BACE1 and GSK-3β in concentration-dependent manners when compared with reference drugs, quercetin and luteolin. Among six components of Kangen-karyu, the water extracts of Salviae Miltiorrhizae Radix or Cyperi Rhizoma exhibited significant inhibitory effects on BACE1 and GSK-3β. Among the constituents of Salviae Miltiorrhizae Radix extract, salvianolic acid C, salvianolic acid A, rosmarinic acid, and magnesium lithospermate B significantly inhibited BACE1. In addition, they inhibited GSK-3β with an IC50 value range of 6.97 to 135.35 μM. From these results, one of the effectiveness and its mechanisms of action of Kangen-karyu against AD may be the inhibition of BACE1 and GSK-3β, and one of the active ingredients of Kangen-karyu is Salviae Miltiorrhizae Radix and its constituents.
Wirat Wasinwong, Mantana Saetang, Thavat Chanchayanon
Journal of Integrative Medicine, Volume 10; https://doi.org/10.30564/jim.v10i2.3459

Abstract:
Internal defibrillation is commonly indicated for shockable rhythm following cross-clamp removal in cardiac surgery. Low energy decreases the success rate of defibrillation but high energy can cause myocardial damage. This study aimed to determine the success rate of internal defibrillation for shockable arrhythmias after cardiac surgery.Retrospective data of 1,424 patients who developed shockable rhythms (ventricular fibrillation or ventricular tachycardia), and required internal defibrillation after aortic cross-clamp removal during cardiac surgery, without deep hypothermic circulatory arrest technique, from August 2015 to July 2017, were reviewed.The overall success rate of internal defibrillation in the first attempt of defibrillation was 61.5%. The success rate of the energy levels at 30, 10, and 7 Jules were 66.7, 64.9, and 61.5%, respectively. The success rate was higher in patients who had a better ejection fraction than those who failed after defibrillation. This was significantly associated with higher pH, higher bicarbonate, lower serum calcium, and lower total cardioplegic volume during cardiopulmonary bypass (CPB). Redo-valve surgery, valvular surgery, and combined coronary artery bypass graft with valvular surgery had a non-significantly lower success rate (p-value = 0.989). Incidence of failure for defibrillate patients in redo-valvular surgery, combined coronary artery bypass graft with valve surgery, adult congenital heart defect, and valvular surgery; requiring four or five shocks was non-significantly increased. Recurrent rate of ventricular fibrillation/ventricular tachycardia was 13.5%.The success rate of internal defibrillation was not related to the dose of energy used after being weaned off CPB.
Martina Cristaldi, Gabriella Lupo, Melania Olivieri, Giorgia Spampinato, Carmelina D. Anfuso, Dario Rusciano
Journal of Integrative Medicine, Volume 10; https://doi.org/10.30564/jim.v10i2.3382

Abstract:
Inflammatory events in the corneal stroma may activate keratocytes and trigger their transition towards myofibroblasts, which now produce different extracellular matrix (ECM) proteins thus causing corneal opacification.Corneal haze is a frequent side effect after photorefractive keratectomy (PRK) to correct high myopia.Currently, a preventive treatment with mitomycin-c can be used to limit the occurrence of this phenomenon. However, mitomycin-c is a toxic drug, not devoid of side effects, which may occasionally involve the corneal endothelium. Therefore, we have searched for a less risky, natural way, to prevent keratocytes transition. To this purpose, we have used as markers of the phenotype switch the proteins lumican (highly expressed by keratocytes and much less by myofibroblasts) and smooth muscle actin (αSMA) (highly expressed by myofibroblasts and poorly found in keratocytes), beside Fibronectin (Fn), the expression of which is also increased by transforming growth factor-beta (TGFβ treatment. Treatment of human keratocytes with TGFβ was used to induce the protein shift. Among different possible candidates, we have found that vitamins A and E, hyaluronic and lactobionic acids may prevent, either alone, or much better in association, the shift in the ratio between lumican and αSMA and the increased Fn expression. In conclusion, it could be speculated that topic treatment of the ocular surface with an association of these four compounds could be able to prevent or at least limit the occurrence of post-PRK corneal haze, with the additional advantage of lubrication, hydration and antioxidant defense exerted by these molecules.
Biwei Chen, Lili Zhang, Shaozong Chen, Changzhen Gong
Journal of Integrative Medicine, Volume 10; https://doi.org/10.30564/jim.v10i2.3373

Abstract:
To assess the efficacy of acupuncture for treatment of irritable bowel syndrome through meta-analysis of randomized controlled trials in recent 20 years. Online databases, including CNKI, VIP, WANFANG,PubMed, Cochrane Library, Web of Science and Embase were searched for randomized controlled trials (RCTs) of acupuncture for IBS. Retrieval time was from January 1, 2000 to January 31, 2021. According to Jadad scoring criteria,the bias risk and quality assessment of each RCT included were evaluated by two researchers. RevMan 5.3 software was used for the meta analysis. Eight RCTs were selected which include a total of 1181 patients.The control group has 425 patients and the experimental group has 756 patients. The result of meta-analysis indicates that the total effective rate for the experimental group was superior to that of the control group [OR=3.29,95%CI [2.16~5.03](P<0.01)], and the funnel plot was basically symmetric. Acupuncture therapy is shown to have a good safety and compliance record. However, the number of high-quality trials is small, and there are some deficiencies in the methodology of clinical research. Acupuncture, as a supplementary therapy for irritable bowel syndrome, has positive clinical significance and prospects for application. The methodology of clinical research needs to be further improved.
C.P. Ong
Journal of Integrative Medicine, Volume 10; https://doi.org/10.30564/jim.v10i2.3365

Abstract:
The slow-motion practice of Taijiquan, operationally, cultivates the cognitive perception of fascia tension as it is being harnessed to discipline body motion to be in accord with Yin-Yang Balance. The ideal motion that results, bestows liveliness of change and harmonizes body momentum,the hallmarks of maneuverability and force potential for performance. The paper puts forth the proposition that the manifestation of Qi in Taijiquan is primarily the cognitive perception of fascial tension in the functional efficacy of bipedal balance for performance. Though the cultivated cognition may be subjective, the process of Qi nurturing is grounded on the reduction of the errors of imbalances, which carves a practice path to balance with tangible effects. The force that arises from body motion so imbued with Yin-Yang Balance, is of the phenomenon of internal strength or neijin—consummate, of the right force vector in spontaneous response and rooted in balance. Taijiquan practice nurtures Qi for both health wellbeing and neijin as the body's core strength, depending on the practice efforts put in.
Lee Suan Chua, Nurhirza Shaiful Yamin
Journal of Integrative Medicine, Volume 10; https://doi.org/10.30564/jim.v10i1.3287

Abstract:
Pueraria mirifica (PM) has traditionally been used to relieve postmenopausal symptoms. Recently, its extract has been developed into various cosmetic products to promote skin rejuvenation and youthfulness. This study investigated the phytochemicals of PM tuber and compared between the tuber flesh and its outer peel. Puerarin which is one of the major isoflavones and being considered as the marker compound was used to determine the presence of PM extract in local cosmetic products. Puerarin could be ionized by a mass spectrometer at both negative and positive modes. The peak ionized at the negative mode showed to have a narrower peak width (0.2 min) and higher signal-to-noise ratio (30) for pueararin (1 mg/L). The results also found PM extract contained many C- and O-glycosylated isoflavones, especially from its peel extract. This explains the peel extract showed to have four times higher antiradical activity than those of flesh extract. Puerarin from the cosmetic products was recovered via successive methanolic sonication and followed by liquid-liquid extraction using ethyl acetate. Puerarin was successfully partitioned from the highly complex chemical mixture of cosmetic products with the recovery ranged from 89.1 % to 115 %. Hence, isoflavones was found to be higher at the outer peels than its tuber flesh. A simple and reliable method has been developed to analyse the presence of PM extract in cosmetic products based on the detection of puerarin after successive extraction via methanolic sonication and ethyl acetate partition.
Jing Wang
Journal of Integrative Medicine, Volume 10; https://doi.org/10.30564/jim.v10i1.2955

Abstract:
To establish HPLC characteristic spectrum of Huoxiang (Herba Agastachis) Eliminating Summer-heat Soft Capsule. Chromatographic separation was performed on Tech Mate C18-ST (5 um, 4.6×250 nm) column by Agilent 1260 high performance liquid chromatograph, eluted with acetonitrile and 0.05% phosphoric acid in a gradient elution at a flow rate of 1.0 mL∙min-1. The detection wavelength was set at 270 nm. Hesperidin was selected as the reference peak to calculate the RSD of the relative retention time. Precision, stability and reproducibility were investigated as well. 80 different samples from 5 manufacturers were included in this study. The HPLC characteristic spectrum of Huoxiang Eliminating Summer-heat Soft Capsule was constructed with 11 specific chromatographic peaks in 80 samples. The method is accurate, reliable and with good reproducibility, and could overall control the quality of Huoxiang Eliminating Summerheat Soft Capsule.
Yi Zhu, Yibo Wang, Fan Yang, Hao Yue, Yi Zhu, Yibo Wang, Fan Yang, Hao Yue
Journal of Integrative Medicine, Volume 10; https://doi.org/10.30564/jim.v10i1.2755

Abstract:
The exploration of fracture internal fixation materials has been one of the research hotspots in the field of biomedical materials. The traditional internal fixation material for fracture is metal fixation. Although its mechanical strength is very large, it can not be degraded and absorbed in human body after implantation of human body or canine joint, which requires a secondary operation to remove, which not only brings pain to patients, but also causes economic pay.[1] Therefore, the development of a biodegradable fracture internal fixation material has become the goal of many researchers. Polylactic acid (PLA) is nontoxic and harmless, has good biocompatibility and strong mechanical properties. It can be degraded in vivo after implantation. The degradation products are CO2 and H2O.[2] For the study of the feasibility of polylactic acid as a substitute for common fracture fixation materials ,18 northern Chinese pastoral dogs were randomly divided into blank group, PLA group and plate group. The data were recorded according to the Wakitani score from the first week to the fifteenth week after operation. First, all the indexes were divided into two categories by principal component analysis [3], then the blank group, steel plate group and PLA group were fitted and compared. Finally, it is concluded that PLA is more beneficial to joint repair than steel plate.
Letícia Dussarrat Brito Oliveira, Maria Da Luz Rosário De Sousa, Maria Lúcia Bressiani Gil, Cássia Maria Grillo, Vera Lúcia Rasera Zotelli, Edson Shizuo Tanaka
Journal of Integrative Medicine, Volume 10; https://doi.org/10.30564/jim.v10i1.3177

Abstract:
In the routine of dental care, complaints of burning sensation, burning tongue and dry mouth are frequent. Due to the complexity of etiology and diagnosis, treating patients with these sensations is a challenge for clinicians. This study aimed to assess acupuncture as an alternative therapy for patients with burning mouth syndrome (BMS). Clinical data were collected from visits of patients to the School of Dentistry of Piracicaba, State University of Campinas, with the application of a protocol of acupuncture points: LI-4 (Hegu), HT-7 (Shenmen), SP-6 (Sanyinjiao), ST36 (Zusanli), REN-23 (Lianquan), REN-6 (Qihai), LI-11 (Quchi), ExHn3 (Yintang), LV-3 (Taichong), ExHn12 (Jinjin), and ExHn13 (Yuye) to treat the symptoms of BMS, from August 2017 to March 2020. The sample consisted of 6 volunteers �?5 female and 1 male patients �?aged 40 to 79 years. The intensity of BMS was assessed before and after each session with self-reported verbal numerical rating scale (VNRS) during the treatment. On average, each patient had 8.16 sessions using 9.92 acupuncture points per session. Variation of VNRS during the treatment showed a decline in burning mouth in most patients, and 83.34% of the sample showed partial or total improvement of symptoms. This study showed that acupuncture was effective in relieving burning mouth, reducing it by 43%, representing an alternative therapy in the management of symptoms of burning mouth syndrome.
C.P. Ong
Journal of Integrative Medicine, Volume 10; https://doi.org/10.30564/jim.v10i1.3220

Abstract:
Qi-nurturing exercises like Taijiquan and Qigong produce significant changes in the body's emissions of electromagnetic energy, which evidence the science in Qi. Reviewing Qi in its functional forms of bioenergy brings scientific familiarity of the abstruse concept. The complexity of Qi transformations in the function of food breakdown and the formation of vital Qi essences reflect the biochemistry of metabolism and the production of ATPs. The review leads to the basic Qi form of Zhen Qi as a representation of ATP and to a new interpretation of the premise of prenatal Qi, relating it to the transmission of mitochondrial DNA. While the basis of Qi and Chinese Medicine is the Taiji Philosophy of Yin and Yang, the regulation of Qi flow in accord with the Principle of Yin-Yang Balance translates to the discipline of the dynamics of bioenergy in homeostasis. The trained cognition of Qi allows for the manipulation of Qi energy at functional pathways to reduce the errors of excessive or deficient Qi levels, that leads to Qi harmony and homeostasis. This opens up a role for Artificial Intelligence via the cognitive perception of Qi to establish the science of Qi.
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