Journal of Integrative Medicine
EISSN : 2315-4616
Published by: Bilingual Publishing Co. (10.30564)
Total articles ≅ 37
Latest articles in this journal
Journal of Integrative Medicine, Volume 10; https://doi.org/10.30564/jim.v10i2.3441
Inhibition of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) or glycogen synthase kinase-3β (GSK-3β) is estimated to be the central therapeutic approach for Alzheimer’s disease (AD). In this study, water extract of Kangenkaryu, its crude drug and chemical composition used in oriental medicine were evaluated regarding their BACE1 and GSK-3β inhibitory activities.Fluorescence resonance energy transfer was used to characterize the BACE1 inhibitory effect of Kangen-karyu, its crude drug and chemical composition.GSK-3β activity was determined using the Kinase-Glo Luminescent Kinase Assay Platform. The water extract of Kangen-karyu inhibited BACE1 and GSK-3β in concentration-dependent manners when compared with reference drugs, quercetin and luteolin. Among six components of Kangen-karyu, the water extracts of Salviae Miltiorrhizae Radix or Cyperi Rhizoma exhibited significant inhibitory effects on BACE1 and GSK-3β. Among the constituents of Salviae Miltiorrhizae Radix extract, salvianolic acid C, salvianolic acid A, rosmarinic acid, and magnesium lithospermate B significantly inhibited BACE1. In addition, they inhibited GSK-3β with an IC50 value range of 6.97 to 135.35 μM. From these results, one of the effectiveness and its mechanisms of action of Kangen-karyu against AD may be the inhibition of BACE1 and GSK-3β, and one of the active ingredients of Kangen-karyu is Salviae Miltiorrhizae Radix and its constituents.
Journal of Integrative Medicine, Volume 10; https://doi.org/10.30564/jim.v10i2.3459
Internal defibrillation is commonly indicated for shockable rhythm following cross-clamp removal in cardiac surgery. Low energy decreases the success rate of defibrillation but high energy can cause myocardial damage. This study aimed to determine the success rate of internal defibrillation for shockable arrhythmias after cardiac surgery.Retrospective data of 1,424 patients who developed shockable rhythms (ventricular fibrillation or ventricular tachycardia), and required internal defibrillation after aortic cross-clamp removal during cardiac surgery, without deep hypothermic circulatory arrest technique, from August 2015 to July 2017, were reviewed.The overall success rate of internal defibrillation in the first attempt of defibrillation was 61.5%. The success rate of the energy levels at 30, 10, and 7 Jules were 66.7, 64.9, and 61.5%, respectively. The success rate was higher in patients who had a better ejection fraction than those who failed after defibrillation. This was significantly associated with higher pH, higher bicarbonate, lower serum calcium, and lower total cardioplegic volume during cardiopulmonary bypass (CPB). Redo-valve surgery, valvular surgery, and combined coronary artery bypass graft with valvular surgery had a non-significantly lower success rate (p-value = 0.989). Incidence of failure for defibrillate patients in redo-valvular surgery, combined coronary artery bypass graft with valve surgery, adult congenital heart defect, and valvular surgery; requiring four or five shocks was non-significantly increased. Recurrent rate of ventricular fibrillation/ventricular tachycardia was 13.5%.The success rate of internal defibrillation was not related to the dose of energy used after being weaned off CPB.
Journal of Integrative Medicine, Volume 10; https://doi.org/10.30564/jim.v10i2.3382
Inflammatory events in the corneal stroma may activate keratocytes and trigger their transition towards myofibroblasts, which now produce different extracellular matrix (ECM) proteins thus causing corneal opacification.Corneal haze is a frequent side effect after photorefractive keratectomy (PRK) to correct high myopia.Currently, a preventive treatment with mitomycin-c can be used to limit the occurrence of this phenomenon. However, mitomycin-c is a toxic drug, not devoid of side effects, which may occasionally involve the corneal endothelium. Therefore, we have searched for a less risky, natural way, to prevent keratocytes transition. To this purpose, we have used as markers of the phenotype switch the proteins lumican (highly expressed by keratocytes and much less by myofibroblasts) and smooth muscle actin (αSMA) (highly expressed by myofibroblasts and poorly found in keratocytes), beside Fibronectin (Fn), the expression of which is also increased by transforming growth factor-beta (TGFβ treatment. Treatment of human keratocytes with TGFβ was used to induce the protein shift. Among different possible candidates, we have found that vitamins A and E, hyaluronic and lactobionic acids may prevent, either alone, or much better in association, the shift in the ratio between lumican and αSMA and the increased Fn expression. In conclusion, it could be speculated that topic treatment of the ocular surface with an association of these four compounds could be able to prevent or at least limit the occurrence of post-PRK corneal haze, with the additional advantage of lubrication, hydration and antioxidant defense exerted by these molecules.
Journal of Integrative Medicine, Volume 10; https://doi.org/10.30564/jim.v10i2.3373
To assess the efficacy of acupuncture for treatment of irritable bowel syndrome through meta-analysis of randomized controlled trials in recent 20 years. Online databases, including CNKI, VIP, WANFANG,PubMed, Cochrane Library, Web of Science and Embase were searched for randomized controlled trials (RCTs) of acupuncture for IBS. Retrieval time was from January 1, 2000 to January 31, 2021. According to Jadad scoring criteria,the bias risk and quality assessment of each RCT included were evaluated by two researchers. RevMan 5.3 software was used for the meta analysis. Eight RCTs were selected which include a total of 1181 patients.The control group has 425 patients and the experimental group has 756 patients. The result of meta-analysis indicates that the total effective rate for the experimental group was superior to that of the control group [OR=3.29,95%CI [2.16~5.03](P<0.01)], and the funnel plot was basically symmetric. Acupuncture therapy is shown to have a good safety and compliance record. However, the number of high-quality trials is small, and there are some deficiencies in the methodology of clinical research. Acupuncture, as a supplementary therapy for irritable bowel syndrome, has positive clinical significance and prospects for application. The methodology of clinical research needs to be further improved.
Journal of Integrative Medicine, Volume 10; https://doi.org/10.30564/jim.v10i2.3365
The slow-motion practice of Taijiquan, operationally, cultivates the cognitive perception of fascia tension as it is being harnessed to discipline body motion to be in accord with Yin-Yang Balance. The ideal motion that results, bestows liveliness of change and harmonizes body momentum,the hallmarks of maneuverability and force potential for performance. The paper puts forth the proposition that the manifestation of Qi in Taijiquan is primarily the cognitive perception of fascial tension in the functional efficacy of bipedal balance for performance. Though the cultivated cognition may be subjective, the process of Qi nurturing is grounded on the reduction of the errors of imbalances, which carves a practice path to balance with tangible effects. The force that arises from body motion so imbued with Yin-Yang Balance, is of the phenomenon of internal strength or neijin—consummate, of the right force vector in spontaneous response and rooted in balance. Taijiquan practice nurtures Qi for both health wellbeing and neijin as the body's core strength, depending on the practice efforts put in.
Journal of Integrative Medicine, Volume 10; https://doi.org/10.30564/jim.v10i1.3220
Qi-nurturing exercises like Taijiquan and Qigong produce significant changes in the body's emissions of electromagnetic energy, which evidence the science in Qi. Reviewing Qi in its functional forms of bioenergy brings scientific familiarity of the abstruse concept. The complexity of Qi transformations in the function of food breakdown and the formation of vital Qi essences reflect the biochemistry of metabolism and the production of ATPs. The review leads to the basic Qi form of Zhen Qi as a representation of ATP and to a new interpretation of the premise of prenatal Qi, relating it to the transmission of mitochondrial DNA. While the basis of Qi and Chinese Medicine is the Taiji Philosophy of Yin and Yang, the regulation of Qi flow in accord with the Principle of Yin-Yang Balance translates to the discipline of the dynamics of bioenergy in homeostasis. The trained cognition of Qi allows for the manipulation of Qi energy at functional pathways to reduce the errors of excessive or deficient Qi levels, that leads to Qi harmony and homeostasis. This opens up a role for Artificial Intelligence via the cognitive perception of Qi to establish the science of Qi.
Journal of Integrative Medicine, Volume 10; https://doi.org/10.30564/jim.v10i1.3177
In the routine of dental care, complaints of burning sensation, burning tongue and dry mouth are frequent. Due to the complexity of etiology and diagnosis, treating patients with these sensations is a challenge for clinicians. This study aimed to assess acupuncture as an alternative therapy for patients with burning mouth syndrome (BMS). Clinical data were collected from visits of patients to the School of Dentistry of Piracicaba, State University of Campinas, with the application of a protocol of acupuncture points: LI-4 (Hegu), HT-7 (Shenmen), SP-6 (Sanyinjiao), ST36 (Zusanli), REN-23 (Lianquan), REN-6 (Qihai), LI-11 (Quchi), ExHn3 (Yintang), LV-3 (Taichong), ExHn12 (Jinjin), and ExHn13 (Yuye) to treat the symptoms of BMS, from August 2017 to March 2020. The sample consisted of 6 volunteers �?5 female and 1 male patients �?aged 40 to 79 years. The intensity of BMS was assessed before and after each session with self-reported verbal numerical rating scale (VNRS) during the treatment. On average, each patient had 8.16 sessions using 9.92 acupuncture points per session. Variation of VNRS during the treatment showed a decline in burning mouth in most patients, and 83.34% of the sample showed partial or total improvement of symptoms. This study showed that acupuncture was effective in relieving burning mouth, reducing it by 43%, representing an alternative therapy in the management of symptoms of burning mouth syndrome.
Journal of Integrative Medicine, Volume 10; https://doi.org/10.30564/jim.v10i1.3200
The kinds of special prescriptions in the book of Chengfang Qieyong cover a wide range of subjects such as internal medicine, gynecology, pediatrics and surgery, etc. These prescriptions have gathered the original discussions of doctors of all ages, condensed the author's own in-depth insights, and displayed the profound connotation of traditional Chinese medicine prescriptions or clinical efficacy characteristics. Guided by the function and categories of the original monograph, 26 prescriptions were integrated into seven categories, i.e.treating Qi and regulating Blood, nourishing and eliminating, exterior dispersing and dispelling cold, compromising and purging fire, drying dampness and expelling phlegm, fetal birth and baby, and carbuncle. Based on the characteristics of clinical efficacy, the connotation of legislative prescriptions, the modification of prescriptions and medicines, and the degree of decoction and prescription, etc, this paper analyzes the connotation of traditional Chinese medicine of these special prescriptions, and provides important reference for the research of modern prescriptions, the expansion of clinical application and the development of new drugs of traditional Chinese medicine.
Journal of Integrative Medicine, Volume 10; https://doi.org/10.30564/jim.v10i1.3230
Metabolic syndrome is the cluster of diseases, which is manifested by central obesity, impaired glucose tolerance, lipodystrophy, and high blood pressure. These metabolic syndrome-related traits significantly increase the risk of type 2 diabetes, adverse cardiac events, stroke, and hepatic steatosis. In the past decade, several organizations have proposed different diagnostic criteria. The use of traditional Chinese medicine to treat metabolic syndrome has received increasing attention due to its wide availability. In this paper, we report a case of three patients with metabolic syndrome with improved administration of 7.5 g of Kangen-karyu extract per day for 6 months. We present and discuss evidence supporting the possibility of using Kangenkaryu for metabolic syndrome.
Journal of Integrative Medicine, Volume 10; https://doi.org/10.30564/jim.v10i1.2992
The study is to describe a patient with urticarial lesions which was successfully treated with mindfulness and nutraceuticals. A 20-year-old female patient with an unmarked past medical history presented with diffuse pruritic urticarial lesions associated with breathless and severe fatigue, lasting for 5 months. The lesions covered all body, except palms and plants. Hospitalized for three days, she received dexamethasone, promethazine, and subcutaneous adrenalin and discharged with fexofenadine, prednisone, and ranitidine. Mindfulness and relaxation practice were instructed and some nutraceuticals. After two months, she returned asymptomatic, without any new episodes of urticaria or fatigue. Most of the chronic urticaria patients are treated with antihistamines and/or steroids. This case illustrates an alternative holistic approach, combining mindfulness and relaxation practices with nutraceuticals. This alternative therapeutical strategy should be explored by back to back comparison to the conventional pharmaceutical approach.