Journal of Integrative Medicine
EISSN : 2315-4616
Published by: Bilingual Publishing Co. (10.30564)
Total articles ≅ 46
Latest articles in this journal
Journal of Integrative Medicine, Volume 11, pp 22-28; https://doi.org/10.30564/jim.v11i1.4691
Immune thrombocytopenia (ITP), also known as idiopathic thrombocytopenic purpura, is a hematologic disease in which platelet destruction increases and production decreases, mainly mediated by immunity. However, up to now, the pathogenesis of ITP is not clear, which has caused great trouble in treatment. Therefore, this paper intends to review the recent literature on ITP treatment to provide some reference for clinical treatment. This paper combines the evidence of ASH immune thrombocytopenia and the Chinese Guidelines for the Diagnosis and Treatment of Adult primary immune thrombocytopenia (2020 edition). In this paper, the treatment process of ITP was divided into first-line treatment and second-line treatment, and it was concluded that first-line treatment was often used when newly diagnosed with ITP: combination of high-dose dexamethasone and low-dose gamma globulin. However, it should be noted that only 60%-80% of patients responded to first-line treatment, and most of them relapsed during dosing reduction or drug withdrawal. Second-line treatment is recommended in this case. The standard treatment is splenectomy, but due to its uncontrollable nature and side effects, it should be used cautiously. A new treatment approach, thrombogenin receptor agonist, has great development potential, and multidrug combination therapy for ITP has positive clinical significance.
Journal of Integrative Medicine, Volume 11, pp 8-11; https://doi.org/10.30564/jim.v11i1.4466
Objective:To observe the changes of cytokines in serum of rabbits with acute pulmonary embolism, and to provide scientific basis for clinical treatment of the disease.Methods: The animal models of pulmonary embolism were established in 26 healthy rabbits by autologous thrombus reinfusion and normal saline injection, and the serum levels of cytokines (TNF-α, IL-1β, HGF) in the two groups were monitored by enzyme-linked immunosorbent assay.Results: The expression levels of serum inflammatory cytokines (TNF-α, IL-1β) increased in both groups of rabbits within 1-3 hours of the acute stage of embolism, but the expression levels of serum inflammatory cytokines in experimental group of rabbits with pulmonary embolism caused by thrombosis increased more obviously；There was no significant change in serum HGF of rabbits before and after embolization in group B. The serum HGF content of experimental rabbits at 1h, 3h, 12h, 24h and 48h after embolization was significantly higher than that before embolization.And in the acute stage of embolism (1-12 hours), it showed a gradual upward trend.Conclusion: The expression level of serum growth factor is different in different acute stages of pulmonary embolism. Detecting serum cytokines in rabbits with acute pulmonary embolism is of great reference significance for improving clinical diagnosis.
Journal of Integrative Medicine, Volume 11, pp 1-7; https://doi.org/10.30564/jim.v11i1.4112
Conventional medicine-based Chinese herbal prescriptions, have fascinatedmuch attention due to their extensive and unique diversity of biologicaleffects without toxicity and/or adverse effects. Treatment with Hachimijio-gan (Ba-Wei-Di-Huang-Wan in Chinese) improved the dysregulatedlevels of hyperglycemic condition-related oxidative stress generation,advanced glycation endproduct generation, and renal function parameters.These results indicate that Hachimi-jio-gan is a prospective therapeuticagent against the pathogenesis of diabetic nephropathy. Cornel iridoidglycosides and polyphenol are the active compounds of Corni Fructus, theactive component of Hachimi-jio-gan, against kidney damage caused bydiabetes. Additionally, major components of the Corni Fructus, morronisideand 7-O-Galloyl-D-sedoheptulose (GS) are considered to be importantcontributors to prevent and/or delay the onset of kidney damage caused bydiabetes. Chief of all, GS is expected to be developed as a novel therapeuticdrug for the diabetes-accelerated kidney damage.
Journal of Integrative Medicine, Volume 11, pp 12-21; https://doi.org/10.30564/jim.v11i1.4654
The Three Harmony Principle helps to regulate whole-body motion in harmony by balancing and aligning the movements of the body segments. Taijiquan uses the fangsong-relaxtion modality to resolve the switching back and forth of the active muscle forces and the passive tensional forces of tendons, ligaments and fascial tissues. Fangsong induces the modulation of the muscles to resettle in a better state of balance, thus is necessarily a manipulation of the fascial tissues enveloping the muscles, organs and structures. In so doing, fangsong-relaxation cultivates the cognition and sensation of the fascial tensional network, which traditional Taiji theory refers to as Qi. Taijiquan harnesses Qi in the discipline of body motion to balance and align the momenta of the body segments in force transmission. This gives rise to maximal force potential in balance—the force of neijin (internal strength)—in response of application. Crucially, the settling into balance by fangsong functions as a neutral countermovement in the stretch-shorten cycle that primes the muscle-tendon unit in an ever-ready state of action, which endows neijin with the liveliness of response. Secondly, the fangsong manipulation of the fascial tissues serves as a fascial massage and release that provides relief to chronic pain syndrome caused by tenseness of muscles and fascia, a therapy that accrues with the many health benefits of Taijiquan. Lastly, but not least, the attentiveness required in the fangsong process develops into the meditation component of the practice which brings tranquility and the insight of mindfulness. Taijiquan thus bestows the triple gems of neijin, health well-being, and equanimity.
Journal of Integrative Medicine, Volume 10; https://doi.org/10.30564/jim.v10i2.3373
To assess the efficacy of acupuncture for treatment of irritable bowel syndrome through meta-analysis of randomized controlled trials in recent 20 years. Online databases, including CNKI, VIP, WANFANG,PubMed, Cochrane Library, Web of Science and Embase were searched for randomized controlled trials (RCTs) of acupuncture for IBS. Retrieval time was from January 1, 2000 to January 31, 2021. According to Jadad scoring criteria,the bias risk and quality assessment of each RCT included were evaluated by two researchers. RevMan 5.3 software was used for the meta analysis. Eight RCTs were selected which include a total of 1181 patients.The control group has 425 patients and the experimental group has 756 patients. The result of meta-analysis indicates that the total effective rate for the experimental group was superior to that of the control group [OR=3.29,95%CI [2.16~5.03](P<0.01)], and the funnel plot was basically symmetric. Acupuncture therapy is shown to have a good safety and compliance record. However, the number of high-quality trials is small, and there are some deficiencies in the methodology of clinical research. Acupuncture, as a supplementary therapy for irritable bowel syndrome, has positive clinical significance and prospects for application. The methodology of clinical research needs to be further improved.
Journal of Integrative Medicine, Volume 10; https://doi.org/10.30564/jim.v10i2.3382
Inflammatory events in the corneal stroma may activate keratocytes and trigger their transition towards myofibroblasts, which now produce different extracellular matrix (ECM) proteins thus causing corneal opacification.Corneal haze is a frequent side effect after photorefractive keratectomy (PRK) to correct high myopia.Currently, a preventive treatment with mitomycin-c can be used to limit the occurrence of this phenomenon. However, mitomycin-c is a toxic drug, not devoid of side effects, which may occasionally involve the corneal endothelium. Therefore, we have searched for a less risky, natural way, to prevent keratocytes transition. To this purpose, we have used as markers of the phenotype switch the proteins lumican (highly expressed by keratocytes and much less by myofibroblasts) and smooth muscle actin (αSMA) (highly expressed by myofibroblasts and poorly found in keratocytes), beside Fibronectin (Fn), the expression of which is also increased by transforming growth factor-beta (TGFβ treatment. Treatment of human keratocytes with TGFβ was used to induce the protein shift. Among different possible candidates, we have found that vitamins A and E, hyaluronic and lactobionic acids may prevent, either alone, or much better in association, the shift in the ratio between lumican and αSMA and the increased Fn expression. In conclusion, it could be speculated that topic treatment of the ocular surface with an association of these four compounds could be able to prevent or at least limit the occurrence of post-PRK corneal haze, with the additional advantage of lubrication, hydration and antioxidant defense exerted by these molecules.
Journal of Integrative Medicine, Volume 10; https://doi.org/10.30564/jim.v10i2.3365
The slow-motion practice of Taijiquan, operationally, cultivates the cognitive perception of fascia tension as it is being harnessed to discipline body motion to be in accord with Yin-Yang Balance. The ideal motion that results, bestows liveliness of change and harmonizes body momentum,the hallmarks of maneuverability and force potential for performance. The paper puts forth the proposition that the manifestation of Qi in Taijiquan is primarily the cognitive perception of fascial tension in the functional efficacy of bipedal balance for performance. Though the cultivated cognition may be subjective, the process of Qi nurturing is grounded on the reduction of the errors of imbalances, which carves a practice path to balance with tangible effects. The force that arises from body motion so imbued with Yin-Yang Balance, is of the phenomenon of internal strength or neijin—consummate, of the right force vector in spontaneous response and rooted in balance. Taijiquan practice nurtures Qi for both health wellbeing and neijin as the body's core strength, depending on the practice efforts put in.
Journal of Integrative Medicine, Volume 10, pp 60-74; https://doi.org/10.30564/jim.v10i2.4111
During the past decades, populous expansion in mast cell scientific literature came forth with more, than forty-four thousand PubMed publications available to date. Such surge is due to the appreciation of the momentous role of mast cells in the evolution of species, in the development and maintenance of vital physiological functions, such as reproduction, homeostasis, and fluids, diverse immunological roles, and the potential of far-reaching effects despite minute numbers. While the emerging knowledge of the importance of mast cells in equilibrium comes of age when looking at the matter from an evolutionary perspective, the recognition of mast cells beyond detrimental performance in allergies and asthma, during protection against parasites, falters. Beyond well known classical functions, mast cells can process and present antigens,can serve as a viral reservoir, can respond to hormones and xenobiotics,initiate antiviral and antibacterial responses, phagocytosis, apoptosis, and participate in important developmental cornerstones. During evolution,upon the development of a sophisticated niche of innate and adaptive cell populations, certain mast cell functions became partially transmutable,yet the potency of mast cells remained considerable. Reviewing mast cells enables us to reflect on the certitude, that our sophisticated, complex physiology is rooted deeply in evolution, which we carry ancient remnants of, ones that may have decisive roles in our functioning. This communication sets out the goal of characterizing mast cells, particularly the aspects less in limelight yet of immense significance, without the aspiration exhaust it all.
Journal of Integrative Medicine, Volume 10; https://doi.org/10.30564/jim.v10i2.3441
Inhibition of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) or glycogen synthase kinase-3β (GSK-3β) is estimated to be the central therapeutic approach for Alzheimer’s disease (AD). In this study, water extract of Kangenkaryu, its crude drug and chemical composition used in oriental medicine were evaluated regarding their BACE1 and GSK-3β inhibitory activities.Fluorescence resonance energy transfer was used to characterize the BACE1 inhibitory effect of Kangen-karyu, its crude drug and chemical composition.GSK-3β activity was determined using the Kinase-Glo Luminescent Kinase Assay Platform. The water extract of Kangen-karyu inhibited BACE1 and GSK-3β in concentration-dependent manners when compared with reference drugs, quercetin and luteolin. Among six components of Kangen-karyu, the water extracts of Salviae Miltiorrhizae Radix or Cyperi Rhizoma exhibited significant inhibitory effects on BACE1 and GSK-3β. Among the constituents of Salviae Miltiorrhizae Radix extract, salvianolic acid C, salvianolic acid A, rosmarinic acid, and magnesium lithospermate B significantly inhibited BACE1. In addition, they inhibited GSK-3β with an IC50 value range of 6.97 to 135.35 μM. From these results, one of the effectiveness and its mechanisms of action of Kangen-karyu against AD may be the inhibition of BACE1 and GSK-3β, and one of the active ingredients of Kangen-karyu is Salviae Miltiorrhizae Radix and its constituents.
Journal of Integrative Medicine, Volume 10, pp 43-48; https://doi.org/10.30564/jim.v10i2.3716
An adequate vitamin D (vitD) intake (Recommended Daily Allowance,RDA= 5µg) is crucial for health maintenance and its deficiency isassociated with several health problems. The increase in hypovitaminosisD cases and the proliferation of food supplements (FS) that are easilyaccessible by the population, have led to an unrestrained chronicconsumption of FS. VitD may accumulate in the body and originatetoxicity (Tolerable Upper Limit, UL=100 µg). The aim of this study was toevaluate if daily vitD doses mentioned in FS labels are in conformity withRDA. 210 solid and liquid FS (for pediatrics and adults) sold in Portuguesepharmacies, supermarkets, health shops and on the internet were examinedfor indicated daily intake of vitD and compared to RDA and UL values.51.43% of FS have values higher than RDA, 8.57% higher than UL. Theaverage vitD daily dose in FS is 24.48 µg, with a high variability betweensamples (0.25 - 250 µg). Majority of FS labels recommend vitD daily dosesabove RDA and some even above UL, regardless of being for adults orchildren. Therefore, it is crucial that vitD dose in FS is reviewed to ensurethe safety of these products.