Chemistry Letters

Journal Information
ISSN / EISSN : 0366-7022 / 1348-0715
Published by: The Chemical Society of Japan (10.1246)
Total articles ≅ 27,844
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Itaru Suzuki, Yuya Takenaka, Yoshitaka Morishita, Ikuya Shibata
Published: 14 October 2021
Abstract:
The nucleophilic addition of ketene silyl acetals 2 into 2H-azirines 1 proceeded in the presence of Lewis acids such as InX3 or Sc(OTf)3 to give N-unprotected aziridines 3. The mild Lewis acidity of the catalyst is important for the achievement of this coupling. The generated aziridine 3 could then be transformed into either oxazolines or γ–amino carbonyls.
Bozhen Li, Zejun Wang, Yiming Li, Yaping Zhang, Yufeng He, Pengfei Song, Rongmin Wang
Published: 14 October 2021
Abstract:
The hydroxyapatite nanowire (HAnW), a novel synthesized biocompatible material without any transition metals, was applied to catalytic degradation of antibiotics. Importantly, tetracycline (TC), a common drug, could be rapid adsorbed and catalytic degraded by HAnW, and the removal got to 85% within 5 min at room temperature.
Tsukasa Aoyagi, Ryunosuke Yoshino, Yuki Mitsuta, Rikuri Morita, Ryuhei Harada, Yasuteru Shigeta
Published: 14 October 2021
Abstract:
The C-terminal binding protein 2 (CtBP2) plays a role in apoptosis and embryogenesis. Genetic knockout studies have been demonstrated to cause severe developmental defects and embryonic lethality. CtBP2 has three key domains and dimerizes for a significant role by binding with nicotinamide adenine dinucleotide (NADH). However, the molecular mechanism of CtBP2 dimerization and the effect of NADH binding are unknown. In this study, we performed molecular dynamics (MD) and docking simulation to reveal the mechanism of C-terminal binding protein 2 (CtBP2) dimerization and the effect of NADH binding to the dimer formation. Our MD simulation results detected seven salt bridges that are important for CtBP2 dimerization. And docking simulation demonstrated that the holo-monomer gave a higher probability of correct docking pose than the apo-monomer. Moreover, in docking simulation using a PXDLS model peptide, that holo form gave more docking poses than that apo form. These results suggested that the holo form has a structure that facilitates the formation of dimers and the binding of PXDLS peptides.
Baodian Fan, Ping Li, Linqin Jiang, Aijun Yang, Jiansheng Li, Haiyan Luo, Hao Xiong, Lingyan Lin, Yu Qiu
Published: 14 October 2021
Abstract:
Synergetic effects were observed in oriented-NaNbO3/g-C3N4 heterostructure system synthesized from in situ pyrolysis of urea with hydrothermally prepared NaNbO3 microcuboids. Chemically wrapping NaNbO3 with appropriate amount of g-C3N4 forms an efficient heterojunction which separates photoexcited charges and the internal electric field produced by oriented NaNbO3 grains facilitates their transfer. The mechanism developed here is applicable to enhancing photoelectrical utilization in other perovskite systems.
Kota Kurokawa, Hisashi Sugime, Shin-Ichi Naya, Hiroaki Tada
Published: 14 October 2021
Abstract:
Gold truncated nanopyramids smaller than 10 nm with clean surfaces were formed on SrTiO3 naocubes (Au TNPy//SrTiO3 NCs, // denotes heteroepitaxial junction) by the deposition precipitation method without surface modifier, while the shape of Au nanoparticles (NPs) on irregular shaped SrTiO3 NPs was hemisphere-like (Au HS/SrTiO3 NPs). As a probe reaction, the oxidation of o-phenylenediamine (OPD) to 2,3-diaminophenazine (DAP) by H2O2 was carried out with the catalysts in the dark at 25°C. Au TNPy//SrTiO3 NCs exhibit significantly higher catalytic activity for the oxidation reaction than Au HS/SrTiO3 NPs. Kinetic analyses indicated that H2O2 can be more effectively activated to be utilized for the OPD oxidation in the former system than the latter system.
Que D. Nguyen, Kosuke Kikuchi, Mariko Kojima, Takafumi Ueno
Published: 14 October 2021
Abstract:
We investigated the effect of linkers on the dynamics of cargo proteins by using a protein needle (PN) scaffold linked to superfolder green fluorescent proteins (sfGFPs) via various linkers. High-speed atomic force microscopy (HS-AFM) revealed clear images of the sfGFP motions on the PN. The results showed that the mobility of cargo proteins is affected by the flexibility and length of linker as well as the intermolecular interactions between the cargo protein and the scaffold protein.
Hiroyuki Takeda, Makoto Shimo, Gai Yasuhara, Ken Kobori, Motoko S. Asano, Yutaka Amao
Published: 14 October 2021
Abstract:
Three kinds of heteroleptic Cu(I) complexes having a phenanthroline-based ligand acting as a chromophore and bearing benzoxazole, benzothiazole, and thiazole moieties were synthesized. Introduction in the phenanthroline ligands of electron-withdrawing five-membered aryl groups caused large red-shifts in the metal-to-ligand charge transfer bands, showing visible light absorption up to 500 nm. The obtained Cu(I) complexes exhibited emissions with quantum yields of 0.01–0.04 and long lifetimes of 0.4–3 μs.
Koji Yamamoto, Itsuki Yamada, Masaru Kameyama, Yosuke Nakamura
Published: 14 October 2021
Abstract:
Carbazole-containing 1,2-azaborine derivatives bearing various substituents were synthesized by using bora-Friedel–Crafts reactions of 1,8-diphenylcarbazole derivatives, and the substituent effects on their photophysical properties were investigated. Furthermore, three carbazole-containing azaborine dimers with different annulation manners between the azaborine and benzene moieties were also successfully synthesized, and the effects of dimerization and differences in the annulation manners on their photophysical properties were disclosed.
Joshua Kyle Stanfield, Osami Shoji
Published: 14 October 2021
Abstract:
Cytochrome P450BM3 is a haemoenzyme that catalyses the monooxygenation of unactivated C—H bonds. In the absence of an appropriate substrate, however, P450BM3 remains in an inactive state and catalysis does not proceed. Traditionally, mutagenesis has been the mainstay technique employed to overcome this limitation, opening P450BM3 up for non-native substrate hydroxylation. This highlight review will discuss a different approach, wherein native substrate mimics (decoy molecules) are employed to trick P450BM3 into mistakenly hydroxylating non-native substrates. This decoy molecule system has the advantage that the wild-type enzyme can be utilised, and laborious mutagenesis can be avoided. Major developments from the first discovery of decoy molecules to the present day will be briefly covered herein.
Ryota Sugimoto, Masahiro Morimoto, Shigeki Naka
Published: 14 October 2021
Abstract:
We investigated the patterning of organic light-emitting diodes using a blue laser irradiation after making uniform device. Laser patterning was carried out in the atmosphere after the organic layer was deposited. The laser irradiation part was quenched, and it was shown that optional patterning was possible. This technique is expected as a fabrication technique for on-demand pattern emission.
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