ISSN / EISSN : 0366-7022 / 1348-0715
Published by: The Chemical Society of Japan (10.1246)
Total articles ≅ 27,844
Latest articles in this journal
Chemistry Letters; https://doi.org/10.1246/cl.210589
The nucleophilic addition of ketene silyl acetals 2 into 2H-azirines 1 proceeded in the presence of Lewis acids such as InX3 or Sc(OTf)3 to give N-unprotected aziridines 3. The mild Lewis acidity of the catalyst is important for the achievement of this coupling. The generated aziridine 3 could then be transformed into either oxazolines or γ–amino carbonyls.
Chemistry Letters; https://doi.org/10.1246/cl.210572
The hydroxyapatite nanowire (HAnW), a novel synthesized biocompatible material without any transition metals, was applied to catalytic degradation of antibiotics. Importantly, tetracycline (TC), a common drug, could be rapid adsorbed and catalytic degraded by HAnW, and the removal got to 85% within 5 min at room temperature.
Chemistry Letters; https://doi.org/10.1246/cl.210548
The C-terminal binding protein 2 (CtBP2) plays a role in apoptosis and embryogenesis. Genetic knockout studies have been demonstrated to cause severe developmental defects and embryonic lethality. CtBP2 has three key domains and dimerizes for a significant role by binding with nicotinamide adenine dinucleotide (NADH). However, the molecular mechanism of CtBP2 dimerization and the effect of NADH binding are unknown. In this study, we performed molecular dynamics (MD) and docking simulation to reveal the mechanism of C-terminal binding protein 2 (CtBP2) dimerization and the effect of NADH binding to the dimer formation. Our MD simulation results detected seven salt bridges that are important for CtBP2 dimerization. And docking simulation demonstrated that the holo-monomer gave a higher probability of correct docking pose than the apo-monomer. Moreover, in docking simulation using a PXDLS model peptide, that holo form gave more docking poses than that apo form. These results suggested that the holo form has a structure that facilitates the formation of dimers and the binding of PXDLS peptides.
Chemistry Letters; https://doi.org/10.1246/cl.210412
Synergetic effects were observed in oriented-NaNbO3/g-C3N4 heterostructure system synthesized from in situ pyrolysis of urea with hydrothermally prepared NaNbO3 microcuboids. Chemically wrapping NaNbO3 with appropriate amount of g-C3N4 forms an efficient heterojunction which separates photoexcited charges and the internal electric field produced by oriented NaNbO3 grains facilitates their transfer. The mechanism developed here is applicable to enhancing photoelectrical utilization in other perovskite systems.
Chemistry Letters; https://doi.org/10.1246/cl.210544
Gold truncated nanopyramids smaller than 10 nm with clean surfaces were formed on SrTiO3 naocubes (Au TNPy//SrTiO3 NCs, // denotes heteroepitaxial junction) by the deposition precipitation method without surface modifier, while the shape of Au nanoparticles (NPs) on irregular shaped SrTiO3 NPs was hemisphere-like (Au HS/SrTiO3 NPs). As a probe reaction, the oxidation of o-phenylenediamine (OPD) to 2,3-diaminophenazine (DAP) by H2O2 was carried out with the catalysts in the dark at 25°C. Au TNPy//SrTiO3 NCs exhibit significantly higher catalytic activity for the oxidation reaction than Au HS/SrTiO3 NPs. Kinetic analyses indicated that H2O2 can be more effectively activated to be utilized for the OPD oxidation in the former system than the latter system.
Chemistry Letters; https://doi.org/10.1246/cl.210599
We investigated the effect of linkers on the dynamics of cargo proteins by using a protein needle (PN) scaffold linked to superfolder green fluorescent proteins (sfGFPs) via various linkers. High-speed atomic force microscopy (HS-AFM) revealed clear images of the sfGFP motions on the PN. The results showed that the mobility of cargo proteins is affected by the flexibility and length of linker as well as the intermolecular interactions between the cargo protein and the scaffold protein.
Chemistry Letters; https://doi.org/10.1246/cl.210583
Three kinds of heteroleptic Cu(I) complexes having a phenanthroline-based ligand acting as a chromophore and bearing benzoxazole, benzothiazole, and thiazole moieties were synthesized. Introduction in the phenanthroline ligands of electron-withdrawing five-membered aryl groups caused large red-shifts in the metal-to-ligand charge transfer bands, showing visible light absorption up to 500 nm. The obtained Cu(I) complexes exhibited emissions with quantum yields of 0.01–0.04 and long lifetimes of 0.4–3 μs.
Chemistry Letters; https://doi.org/10.1246/cl.210597
Carbazole-containing 1,2-azaborine derivatives bearing various substituents were synthesized by using bora-Friedel–Crafts reactions of 1,8-diphenylcarbazole derivatives, and the substituent effects on their photophysical properties were investigated. Furthermore, three carbazole-containing azaborine dimers with different annulation manners between the azaborine and benzene moieties were also successfully synthesized, and the effects of dimerization and differences in the annulation manners on their photophysical properties were disclosed.
Chemistry Letters; https://doi.org/10.1246/cl.210584
Cytochrome P450BM3 is a haemoenzyme that catalyses the monooxygenation of unactivated C—H bonds. In the absence of an appropriate substrate, however, P450BM3 remains in an inactive state and catalysis does not proceed. Traditionally, mutagenesis has been the mainstay technique employed to overcome this limitation, opening P450BM3 up for non-native substrate hydroxylation. This highlight review will discuss a different approach, wherein native substrate mimics (decoy molecules) are employed to trick P450BM3 into mistakenly hydroxylating non-native substrates. This decoy molecule system has the advantage that the wild-type enzyme can be utilised, and laborious mutagenesis can be avoided. Major developments from the first discovery of decoy molecules to the present day will be briefly covered herein.
Chemistry Letters; https://doi.org/10.1246/cl.210569
We investigated the patterning of organic light-emitting diodes using a blue laser irradiation after making uniform device. Laser patterning was carried out in the atmosphere after the organic layer was deposited. The laser irradiation part was quenched, and it was shown that optional patterning was possible. This technique is expected as a fabrication technique for on-demand pattern emission.