Child's Nervous System

Journal Information
ISSN / EISSN : 0256-7040 / 1433-0350
Current Publisher: Springer Science and Business Media LLC (10.1007)
Former Publisher:
Total articles ≅ 7,995
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, Steven R. Miller, Joshua J. Kovoor
Child's Nervous System pp 1-5; doi:10.1007/s00381-021-05195-8

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John S. Sullivan, Alicia E. Snider, Jeffrey Farrington, J. Mason Shiflett, Kristin J. Weaver, Laura S. Humphries,
Child's Nervous System pp 1-6; doi:10.1007/s00381-021-05202-y

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, European Society for Paediatric Oncology (SIOPE)-Brain Tumour Imaging Group, , , , Monika Warmuth-Metz,
Child's Nervous System pp 1-12; doi:10.1007/s00381-021-05199-4

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Child's Nervous System pp 1-6; doi:10.1007/s00381-021-05198-5

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, Beatriz Mantese, Flavio Requejo
Child's Nervous System pp 1-6; doi:10.1007/s00381-021-05181-0

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Shota Yamashita, , Toshiaki Hayashi, Reizo Shirane, Teiji Tomonaga
Child's Nervous System pp 1-7; doi:10.1007/s00381-021-05045-7

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Wai Cheong Soon, Edward Goacher, Sandeep Solanki, Josie Hayes, Melpo Kapetanstrataki, Susan Picton, ,
Child's Nervous System pp 1-10; doi:10.1007/s00381-021-05165-0

Abstract:
Purpose Evidence exists, in CNS germinomas and medulloblastomas (MB), that patient sex significantly influences incidence and outcome. The role of sex genotype in other paediatric CNS tumours remains unclear. This study sought to examine the role of sex genotype in CNS tumour incidence and overall survival (OS). Methods Age-adjusted incidence and OS rates were collected from the Surveillance Epidemiology and End Result (SEER) registry between 2000 and 2011 for common paediatric (<=19 years) CNS tumours: pilocytic astrocytoma (PA), anaplastic astrocytoma, glioblastoma (GBM), medulloblastoma, supratentorial CNS embryonal tumour, ependymoma, and germinoma. All patients with histologically confirmed, ICD-03 coded, first tumours, were included. Kaplan-Meier and Cox regression analyses were used to calculate hazard ratios (HR). Results The total cases are as follows: males=3018 and females=2276. Highest incidence was seen in PA (n=2103). GBM displayed the worst OS, whilst PA displayed the best. Higher incidence was observed in males for all tumours, except PA. Females with ependymoma had significantly better OS compared to males, whereas males with germinomas had better OS compared to females. Females <1 year with AA had better OS than males. Increasing age significantly improved male and female survival in ependymoma and medulloblastoma. Conclusion Interrogating population-based registries such as SEER minimises bias and provides credible data. Observed differences in incidence and OS between the sexes for different paediatric CNS tumours provide useful prognostic information for clinicians. Sex genotype was a significant independent prognostic factor in ependymomas and germinomas. Further investigation of possible epigenetic and hormonal differences may provide sex-specific vulnerabilities that may be exploitable for targeted therapy.
, Tesifón Parrón-Carreño, José María Narro-Donate, Antonio José Vargas-López, María José Castelló-Ruiz, Fernando García-Pérez, José Javier Guil-Ibáñez, José Masegosa-González
Child's Nervous System; doi:10.1007/s00381-021-05190-z

Micah K. Harris, Margaret Shatara, Zachary Funk, Joseph Stanek, Daniel R. Boué, Jeremy Jones, Jonathan L. Finlay,
Child's Nervous System pp 1-8; doi:10.1007/s00381-021-05197-6

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, Parthasarathi Mondal, Pravin Salunke, Kirti Gupta, Anshul Siroliya
Child's Nervous System pp 1-4; doi:10.1007/s00381-021-05196-7

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