Journal of Ginseng Research

Journal Information
ISSN / EISSN : 1226-8453 / 2093-4947
Published by: Elsevier BV (10.1016)
Total articles ≅ 1,118
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Latest articles in this journal

Sun-Hye Choi, Ra Mi Lee, Han-Sung Cho, Sung Hee Hwang, , Hyewhon Rhim, Hyoung-Chun Kim, Do-Geun Kim, Ik-Hyun Cho,
Published: 15 October 2021
Journal of Ginseng Research; https://doi.org/10.1016/j.jgr.2021.10.004

Abstract:
Gintonin is a ginseng-derived exogenous G-protein-coupled lysophosphatidic acid (LPA) receptor ligand. Gintonin exerts its neuronal and non-neuronal in vitro and in vivo effects through LPA receptor subtypes. However, it is unknown whether gintonin can bind to the plasma membrane of cells and can transactivate the epidermal growth factor (EGF) receptor. In the present study, we examined whether gintonin-biotin conjugates directly bound to LPA receptors and transactivated the EGF receptor.
Soo Hyun Park, Sangwon Chung, Min-Yu Chung, Hyo-Kyoung Choi, Jin-Taek Hwang,
Published: 13 October 2021
Journal of Ginseng Research; https://doi.org/10.1016/j.jgr.2021.10.002

Abstract:
Panax ginseng is a medicinal plant is a material with various pharmacological activities and research suggests that it is particularly effective in representative metabolic diseases such as hyperglycemia, hypertension, and hyperlipidemia. Therefore, in this study, systematic review and meta-analysis were performed to investigate the comprehensive effect of P. ginseng on metabolic parameters representing these metabolic diseases. A total of 23 papers were collected for inclusion in the study, from which 27 datasets were collected. The investigational products included P. ginseng and Korean Red ginseng. Across the included studies, the dose ranged from 200 mg to 8 g and the supplementation period lasted from four to 24 weeks. The study subjects varied from healthy adults to those with diabetes, hypertension, obesity, and/or hyperlipidemia. As a result of the analysis, the levels of glucose and insulin area under the curves, % body fat, systolic and diastolic blood pressures, total cholesterol, triglycerides, and low-density lipoprotein cholesterol were significantly reduced in the P. ginseng group as compared with in the placebo group. In conclusion, P. ginseng supplementation may act as an adjuvant to prevent the development of metabolic diseases by improving markers related to blood glucose, blood pressure, and blood lipids.
Heegu Jin, Hyun-Ji Oh, Seung-Yeol Nah,
Published: 13 October 2021
Journal of Ginseng Research; https://doi.org/10.1016/j.jgr.2021.10.003

Abstract:
Gintonin-enriched fraction (GEF), a non-saponin fraction of ginseng, is a novel glycolipoprotein rich in hydrophobic amino acids. GEF has recently been shown to regulate lipid metabolism and browning in adipocytes; however, the mechanisms underlying its effects on energy metabolism and whether it affects sarcopenic obesity are unclear. We aimed to evaluate the effects of GEF on skeletal muscle atrophy in high-fat diet (HFD)-induced obese mice.
Chang Xu, Liangchang Li, Chongyang Wang, Jingzhi Jiang, Li Li, Lianhua Zhu, Shan Jin, Zhehu Jin, Jung Joon Lee, , et al.
Published: 13 October 2021
Journal of Ginseng Research; https://doi.org/10.1016/j.jgr.2021.10.001

Abstract:
The effect of ginsenoside Rh2 (G-Rh2) on mast cell-mediated anaphylaxis remains unclear. Herein, we investigated the effects of G-Rh2 on OVA-induced asthmatic mice and on mast cell-mediated anaphylaxis.
Seoung Rak Lee, Bum Soo Lee, Jae Sik Yu, Heesun Kang, Min Jeong Yoo, Sang Ah Yi, Jeung-Whan Han, Sil Kim, , Jin-Chul Kim, et al.
Published: 6 October 2021
Journal of Ginseng Research; https://doi.org/10.1016/j.jgr.2021.09.004

Abstract:
Withania somnifera (Solanaceae), generally known as Indian ginseng, is a medicinal plant that is used in Ayurvedic practice for promoting health and longevity. This study aims to identify the bioactive metabolites from Indian ginseng and elucidate their structures.
, Sung Dae Kim, Seung-Chun Park,
Published: 5 October 2021
Journal of Ginseng Research; https://doi.org/10.1016/j.jgr.2021.09.003

Abstract:
Ginseng has been widely studied due to its various therapeutic properties on various diseases such as cardiovascular disease (CVD). Cardiovascular disease has been canonically known to be caused by high levels of low-density lipoproteins (LDL) in the bloodstream, in addition to the impaired vasodilatory effects of cholesterol. However, current research on CVD has revealed a cascade of mechanisms involving a series of events that contribute to the progression of CVD. Although this has been elucidated and summarized in previous studies the detailed correlation between platelet aggregation and innate immunity that plays an important role in CVD progression has not been thoroughly summarized. Furthermore, immune cell subtypes also contribute to the progression of plaque formation in the subendothelial layer. Thrombus formation and the coagulation cascade also have a vital role in the progression of atherosclerosis. Hence, in this mini review we aim to elucidate, summarize, and propose the potent therapeutic effect of ginseng on CVD, mainly on platelet aggregation, plaque formation, and thrombus formation.
, Hong Wang, Ming Zhang, Mengxue Shi, Cailing Yang, Qiang Ni, Qi Wang, Jing Li, Xuemei Wang, Chen Zhang, et al.
Published: 11 September 2021
Journal of Ginseng Research; https://doi.org/10.1016/j.jgr.2021.09.001

Abstract:
In physical activity or labor, the human body is in a state of high intensity stress, and all parts or physiological functions of the body respond positively to maintain or balance the need for movement. The human body has many physiological changes in the process of movement, and fatigue is the external manifestation of various complex changes inside the human body. Fatigue is also a physiological mechanism of self-protection after the body reaches a certain level of activity, which can prevent the occurrence of life-threatening excessive functional failure. The generation of fatigue is a very complex process, and its mechanism has not been concluded yet. Therefore, it is an important work to search and screen the effective components of natural plants that have anti-fatigue effect and to explore their mechanism.
Tae Jin Kim, Do Hyeon Pyun, Myeong Jun Kim, Ji Hoon Jeong, A.M. Abd El-Aty,
Published: 10 September 2021
Journal of Ginseng Research; https://doi.org/10.1016/j.jgr.2021.09.002

Abstract:
Compound K (CK) is among the protopanaxadiol (PPD)-type ginsenoside group, which produces multiple pharmacological effects. Herein, we examined the effects of CK on muscle atrophy under hyperlipidemic conditions along with its pro-myogenic effects. Further, the molecular pathways underlying the effects of CK on skeletal muscle have been justified.
Haixia Pan, Linhan Yang, Hansong Bai, ,
Published: 30 August 2021
Journal of Ginseng Research; https://doi.org/10.1016/j.jgr.2021.08.004

Abstract:
Ginsenoside Rg3 and gemcitabine have mutual enhancing antitumor effects. However, the underlying mechanisms are not clear. This study explored the influence of ginsenoside Rg3 on Zinc finger protein 91 homolog (ZFP91) expression in pancreatic adenocarcinoma (PAAD) and their regulatory mechanisms on gemcitabine sensitivity.
Jae Eun Park, Hyeon Woo Kim, Sung Hwan Yun,
Published: 27 August 2021
Journal of Ginseng Research; https://doi.org/10.1016/j.jgr.2021.08.006

Abstract:
Ginsenoside Rh2, a major saponin derivative in ginseng extract, is recognized for its anticancer activities. Compared to coding genes, studies on long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) that are regulated by Rh2 in cancer cells, especially on competitive endogenous RNA (ceRNA) are sparse.
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