ISSN / EISSN : 2051-7599 / 2051-7599
Published by: Faculty of 1000, Ltd. (10.12703)
Total articles ≅ 239
Latest articles in this journal
F1000Prime Reports, Volume 7; https://doi.org/10.12703/p7-64
Cystic fibrosis is the most common autosomal recessive genetic disease in Caucasians and has been extensively studied for many decades. The cystic fibrosis transmembrane conductance regulator gene was identified in 1989. It encodes a complex protein which has numerous cellular functions. Our understanding of cystic fibrosis pathophysiology and genetics is constantly expanding and being refined, leading to improved management of the disease and increased life expectancy in affected individuals.
F1000Prime Reports, Volume 7; https://doi.org/10.12703/p7-65
Globally, intimate partner violence (IPV) is a pervasive and insidious human rights problem with significant adverse physical health outcomes for women. Intimate partner violence has also been closely associated with poor mental health and substance use problems. However, little is known about the relationship among these co-occurring problems and how to best intervene or manage them. Here, we present findings from recent systematic reviews and meta-analyses (where available) to highlight developments in understanding and managing the complex co-occurring problems of intimate partner violence and mental health and substance use in women.
F1000Prime Reports, Volume 7; https://doi.org/10.12703/p7-62
Giardia lamblia is a flagellated protozoan that is the most common cause of intestinal parasitic infection in children living in resource-limited settings. The pathogenicity of Giardia has been debated since the parasite was first identified, and clinical outcomes vary across studies. Among recent perplexing findings are diametrically opposed associations between Giardia and acute versus persistent diarrhea and a poorly understood potential for long-term sequelae, including impaired child growth and cognitive development. The mechanisms driving these protean clinical outcomes remain elusive, but recent advances suggest that variability in Giardia strains, host nutritional status, the composition of microbiota, co-infecting enteropathogens, host genetically determined mucosal immune responses, and immune modulation by Giardia are all relevant factors influencing disease manifestations after Giardia infection.
F1000Prime Reports, Volume 7; https://doi.org/10.12703/p7-61
The purpose of this article is to review recent advances in the treatment of epilepsy. It includes five antiepileptic drugs that have been recently added to the pharmacologic armamentarium and surgical techniques that have been developed in the last few years. Finally, we review ongoing research that may have a potential role in future treatments of epilepsy.
F1000Prime Reports, Volume 7; https://doi.org/10.12703/p7-63
Sleep disturbance is common during the menopausal transition, with numerous downstream consequences to health and functioning, including reduced quality of life, impaired mental health, and increased physical health morbidity. Insomnia affects approximately 50% of midlife women and is characterized by nocturnal symptoms of difficulties initiating or maintaining sleep (or both) and daytime symptoms that impair occupational, social, or other components of functioning. In addition, approximately 20% of midlife women develop sleep-disordered breathing during the menopausal transition. This commentary summarizes the prevalence, risk factors, and treatment options for each of these sleep disorders in midlife women, with specific focus on first-line treatments for insomnia (cognitive behavioral therapy for insomnia) and sleep-disordered breathing (continuous positive airway pressure) and unique considerations for treating sleep disorders in midlife women. Future directions are also discussed.
F1000Prime Reports, Volume 7; https://doi.org/10.12703/p7-66
The molecular and genetic mechanisms in most patients with inherited platelet dysfunction are unknown. There is increasing evidence that mutations in hematopoietic transcription factors are major players in the pathogenesis of defective megakaryopoiesis and platelet dysfunction in patients with inherited platelet disorders. These hematopoietic transcription factors include RUNX1, FLI1, GATA-1, and GFI1B. Mutations involving these transcription factors affect diverse aspects of platelet production and function at the genetic and molecular levels, culminating in clinical manifestations of thrombocytopenia and platelet dysfunction. This review focuses on these hematopoietic transcription factors in the pathobiology of inherited platelet dysfunction.
F1000Prime Reports, Volume 7; https://doi.org/10.12703/p7-56
The search for novel analgesics: targets and mechanisms
F1000Prime Reports, Volume 7; https://doi.org/10.12703/p7-50
Advances in the prevention of Alzheimer's Disease
F1000Prime Reports, Volume 7; https://doi.org/10.12703/p7-59
Recent advances in understanding and managing rhabdomyosarcoma
F1000Prime Reports, Volume 7; https://doi.org/10.12703/p7-60
Tachycardia, conventionally, but arbitrarily, defined as an atrial and/or ventricular rate of >100 beats per minute, is encountered commonly and can be physiological or pathological in origin. Various adverse consequences from tachycardia have been recognized, and an important one is the association between persistent tachycardia and cardiomyopathy. In this article, we provide an up-to-date review on the etiology of tachycardia, management strategies, and the prognosis of patients presenting with tachycardia and cardiomyopathy.