Russian Journal of Cardiology

Journal Information
ISSN / EISSN : 1560-4071 / 2618-7620
Current Publisher: Silicea - Poligraf, LLC (10.15829)
Total articles ≅ 1,418
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D. A. Lebedev, E. A. Lyasnikova, A. A. Vasilyeva, E. Yu. Vasilyeva, A. Yu. Babenko, E. V. Shlyakhto
Russian Journal of Cardiology, Volume 25; doi:10.15829/1560-4071-2020-3967

Abstract:
Aim. To study molecular biomarkers in patients with type 2 diabetes (T2D) in combination with heart failure with preserved (HFpEF) and mid-range ejection fraction (HFmrEF) and compare the data obtained with clinical characteristics of myocardial remodeling.Material and methods. The study included 42 patients with T2D (men — 53%, mean age — 60 years) with clinical manifestations of class II HF: 29 patients with HFpEF (group 1) and 13 patients with HFmrEF (group 2). The control group consisted of 13 healthy people, which were comparable in sex and age and had a normal body mass index (BMI). Patients received stable glucose-lowering and optimal drug therapy for HF for 3 months prior to enrollment in the study. Patients with HFpEF and HFmrEF were comparable in clinical and demographic parameters, had glycated hemoglobin (HbA ) of 8,5% and 8,8%, respectively (p>0,05), increased BMI or grade I-II obesity.We studied following biomarkers: NT-proBNP, highly sensitive C-reactive protein (hsCRP), sST2, galectin-3, procollagen type I C-terminal propeptide (PICP), matrix metalloproteinase 9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1).Results. Volumetric parameters of the left ventricle (LV),LV mass indexed to growth and NT-proBNP were higher in the group of HFpEF patients (pConclusion. Patients with HFmrEF and T2D have higherLV volume and mass, higher concentrations of NT-proBNP and PICP in comparison with patients with HFpEF. The direction of MMP-9/TIMP-1 changes may reflect a decrease in antifibrotic processes. Further prospective studies on large samples using a multiple biomarker model are required in T2D and various HF phenotypes.
С. И. Карась, E. V. Grakova, M. V. Balakhonova, M. B. Arzhanik, E. E. Kara-Sal
Russian Journal of Cardiology, Volume 25; doi:10.15829/1560-4071-2020-4116

Abstract:
Aim. To create a methodological base for distance learning of cardiology healthcare professionals — multimedia clinical diagnostic tasks.Material and methods. The interdisciplinary team used text and multimedia formats for clinical diagnostic data. Web technologies provided remote access to information located on the server.Results. The report presents the experience of the practical implementation of multimedia clinical diagnostic tasks in cardiology, including the augmented reality. The variability of presenting information to students is implemented in the multimedia clinical diagnostic tasks, which is integrated with the rating system for evaluating decisions. The solution paths are determined by the actions of the students in the trigger interactive blocks and is evaluated by the rating system. Personal rating is a numerical value that integrally characterizes the decisionmaking competence of students. The conversion of the quantitative rating into the conventional form (‘pass/fail’, ‘excellent’, ‘good’, ‘passing grade’) will be provided after the trial period of the software.Conclusion. The created Web service and computer simulations can become a methodological basis for the distance learning in cardiology. This technology can be in demand in the continuing medical education.
T. B. Pecherina, A. G. Kutikhin
Russian Journal of Cardiology, Volume 25; doi:10.15829/1560-4071-2020-3933

Abstract:
Currently, the development of chronic heart failure (CHF) is considered from the perspective of pathological structural remodeling of myocardium and fibrosis. Despite the widespread use of molecular genetic markers in clinical practice, only a small number of them are used to evaluate remodeling processes, as well as to predict potential complications associated with heart failure (HF). In addition, the relationship between many biomarkers with instrumental and histological confirmation of myocardial fibrosis has not yet been determined. Myocardial fibrosis remains quite debatable and controversial subject, which actualizes the further study of this direction. The discovery of pathogenetic and diagnostic markers of myocardial fibrosis could contribute to the development of targeted therapy. Of particular interest is the search for possible pathogenetic markers, since this is relevant for clinical practice.
Yu. A. Karpov, V. M. Gorbunov, N. A. Logunova
Russian Journal of Cardiology, Volume 25; doi:10.15829/1560-4071-2020-4130

Abstract:
The article presents the main results of the Russian post-marketing multicenter open-label program TRICOLOR (Triple fixed-dose combination in the treatment of hypertension).Aim. To evaluate the antihypertensive efficacy and tolerability of the triple amlodipine/indapamide/perindopril fixed-dose combination, as well as the adherence of hypertensive (HTN) patients to this therapy in actual clinical practice.Material and methods. The program enrolled 1247 outpatients aged 18 to 79 of both sexes with essential HTN. All patients included in the study receive amlodipine/ indapamide/perindopril fixed-dose combination. The patient’s condition was assessed according to four visits: visit 1 — at inclusion, visit 2 — after 2 weeks, visit 3 — after 4 weeks, visit 4 — after 12 weeks of follow-up. At each visit, the achievement of the target blood pressure (BP) Results. After 12 weeks, a significant decrease in systolic and diastolic BP was recorded — by 33,5 and 14,3 mm Hg, respectively (pConclusion. The results of the TRICOLOR program demonstrate a high antihypertensive efficacy, good tolerance and medical adherence of triple amlodipine/indapamide/perindopril fixed-dose combination in patients with essential HTN in actual clinical practice in Russia.
A. O. Konradi, A. L. Maslyansky, E. P. Kolesova, E. N. Shlyakhto, P. L.M. Kerkhof
Russian Journal of Cardiology, Volume 25; doi:10.15829/1560-4071-2020-3929

The publisher has not yet granted permission to display this abstract.
S. Yu. Nikulina, O. O. Kuznecova, A. A. Chernova, V. N. Maksimov
Russian Journal of Cardiology, Volume 25; doi:10.15829/1560-4071-2020-3960

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T. G. Vaikhanskaya, L. N. Sivitskaya, T. V. Kurushko, T. V. Rusak, O. D. Levdansky, N. G. Danilenko, O. G. Davydenko
Russian Journal of Cardiology, Volume 25; doi:10.15829/1560-4071-2020-3863

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O. N. Tkacheva, N. M. Vorob’Eva, Yu. V. Kotovskaya, O. D. Ostroumova, M. S. Chernyaeva, M. V. Silyutina, A. V. Chernov, S. G. Testova, L. N. Ovcharova, E. V. Selezneva
Russian Journal of Cardiology, Volume 25; doi:10.15829/1560-4071-2020-3985

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B. N. Kozlov, D. S. Panfilov, E. L. Sonduev, V. L. Lukinov
Russian Journal of Cardiology, Volume 25; doi:10.15829/1560-4071-2020-3887

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Yu. A. Vakhrushev, T. I. Vershinina, P. A. Fedotov, A. A. Kozyreva, A. M. Kiselev, Yu. V. Fomicheva, E. S. Vasichkina, T. M. Pervunina, A. A. Kostareva
Russian Journal of Cardiology, Volume 25; doi:10.15829/1560-4071-2020-4027

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