Lung cancer seriously endangers human health and is a major public health problem. The Xuanwei region in northeastern Yunnan province has one of the highest lung cancer mortality rates in the world. In the past ten years, researchers have explored and revealed the causes and molecular mechanisms of the high incidence of lung cancer in Xuanwei from different perspectives. Significant progress has been made in the study of its special environmental factors to molecular mechanisms such as genetic susceptibility, DNA methylation, and noncoding RNA. This paper reviews the research progress on the characteristics and risk factors of lung cancer in Xuanwei area.

Objective: To investigate the risk factors of complicated pelvic lymph cyst after lymph node dissection in patients with endometrial cancer to guide the control of lymph cyst. Methods: The 168 cases of endometrial cancer patients undergoing laparoscopic lymph node dissection of Qingdao were selected to analyze the postoperative risk factors of lymphocyst. Results: The incidence of lymphocysts was 26.8%; univariate analysis showed that the number of lymphadenectomies, serum albumin level, abdominal surgery, omentectomy, intraoperative amount of bleeding (P < 0.05); multiple logistic regression analysis showed that the number of lymphadenectomy and serum albumin levels were independent risk factors for lymphadenectomy in patients with endometrial cancer. Conclusion: The incidence of pelvic lymph cyst is high after lymph node dissection, and the number and range of lymphadenectomy, serum albumin levels are their independent risk factors, which should be paid attention to and prevented.

Objective: Targeted killing of laryngeal cancer stem cells has become a consensus in the treatment of laryngeal cancer. Methods: The chitosan-polyethylene glycol sustained-release nanoparticles (mPEG-CS-cRGD/Bmi-1RNAi-PTX) co-loaded with PTX and Bmi-1RNAi previously constructed were used. The effects of mPEG-CS-cRGD/Bmi-1RNAi-PTX nanoparticles on the proliferation and apoptosis of laryngeal carcinoma Hep-2 cells and laryngeal carcinoma Hep-2 cells in tumor-bearing nude mice models and their safety were confirmed by in vitro and in vivo experiments. The expression ratios of CD133 and C-myc genes before and after treatment with PTX and mPEG-CS-cRGD/Bmi-1RNAi-PTX nanoparticles were compared. Results: Compared with the single application of PTX chemotherapy, the nanoparticles combined with chemotherapy drugs can significantly inhibit the proliferation of laryngeal carcinoma Hep-2 cells, promote apoptosis, and significantly inhibit the growth of transplanted tumors, with biological safety. At the same time, the expression levels of CD133 and C-myc in laryngeal cancer stem cells can be reduced in vitro and in vivo, respectively. Conclusion: cRGD peptide, paclitaxel and Bmi-1RNAi can kill laryngeal cancer stem cells with multiple targets and have overlapping synergistic mechanism.

Objective: To explore the influence of 6 MV X-ray and 10 MV X-ray on the VMAT plan of rectal cancer in flattening filter-free (FFF) mode, and to provide a reference for the selection of radiation quality for rectal cancer radiotherapy. Methods: Twenty patients with rectal cancer after surgery were selected for retrospective analysis, and the VMAT plan of FFF-6 MV and the VMAT plan of FFF-10 MV were designed on the Eclipse 13.6 planning system. The dose volume histograms of the two plans, the conformity index (CI) of the target area, the homogeneous index (HI) and the dosimetry parameters of the bladder, left and right femoral heads, small intestine, and normal tissues (B-P), and the dose verification passed Rate, Monitor unit count, treatment time difference were compared. Results: The D2 and Dmean differences between 6 MV X-ray and 10 MV X-ray plans were statistically significant (P 0.05). CI and HI in the 6 MV plan group were better than those in the 10 MV plan group (P 0.05), the result of V50 of 6 MV was less than 10 MV plan (P 0.05), normal tissue V2 and V5 were 10 MV Lower than the 6 MV plan (P < 0.05). The passing rate of dose verification, the number of monitor unit, and the treatment time were all in the 6 MV plan less than the 10 MV plan (P < 0.05). Conclusion: Both plans could meet the clinical requirements, considering that most of the organs at risk have no significant difference, and the conformity index (CI) and uniformity index (HI) of the target area at 6 M X energy in FFF mode are better than 10 MV X-ray, and the number of monitor units is less, it is recommended to use 6 MV X energy to develop a rectal cancer VMAT plan in FFF mode.

Colorectal cancer is a cancer with a high incidence of new cases and deaths in the world, and its pathogenesis needs to be further studied. Vascular endothelial cell growth factor can promote the formation of new blood vessels and play an important role in the process of tumor proliferation, invasion and migration. Adipokines include leptin, adiponectin, retinin and cytokines, and these adipokines are closely related to the occurrence and development of colorectal cancer. This paper reviews the relationship between the occurrence and development of colorectal cancer and vascular endothelial cell growth factor and adipokine as well as the relationship between vascular endothelial cell growth factor and adipokine, hoping to provide a positive theoretical basis for the prevention and treatment of colorectal cancer.

Esophageal cancer is a common malignant tumor of digestive system, and its incidence is increasing. Worldwide, it has the seventh highest incidence and the sixth highest death rate. The survival rate of early esophageal cancer is significantly higher than that of middle and late esophageal cancer, indicating the importance of early diagnosis. Early esophageal cancer treatment methods: Endoscopy, surgery, radiotherapy, chemotherapy and so on. Follow-up can monitor the therapeutic effect and recurrence.

The tumor necrosis factor receptor (TNF-R)-associated factor (TRAF) family has seven members and is characterized as signaling transduction molecules coupled to the cytoplasmic regions of the TNF-R superfamily. All the TRAFs proteins functionally act as a scaffold and/or enzymatic proteins to regulate activation of mitogen-activated protein kinases (MAPKs) and transcription factors of nuclear factor-κB family (NF-κB). All TRAFs have been identified to be widely involved in embryonic development, tissue homeostasis, and regulation of innate and adaptive immune responses. TRAF7, as the last discovered member of the TRAFs protein with E3 ligase activation, containing an N-terminal RING finger domain and a C-terminal WD40 domain, has been identified to be involved in the genesis and progression of several human cancers, suggesting TRAF7 as a novel tumor suppressor protein. The paper attempts to review the role of TRAF7 in the genesis and progression of Meningioma, Mesothelioma and Hepatocellular Carcinoma, hoping to be helpful for understanding tumor pathogenesis and therapeutic targets.

Breast cancer occupies the first place in the occurrence of female malignant tumors. Connexin 43 (Cx43) has abnormal expression in breast cancer, and plays a role in the occurrence and development of breast cancer. This article mainly discusses the research progress of Cx43 in breast cancer, and discusses its expression in normal breast tissue, primary breast cancer and distant metastasis, so as to provide new ideas for the treatment of breast cancer.

Objectives: To explore the effect of supportive care based on neuro-linguistic programming (NLP) technology on breast cancer-associated lymphedema and negative emotion intervention. Methods: From January 2018 to June 2019, forty breast cancer patients who underwent modified radical mastectomy in our hospital were enrolled into this study. All patients were randomly divided into observational group and control group, 20 cases in each group. The patients in the control group received routine nursing care, while the patients in the observational group received supportive care based on NLP technology on the basis of the control group. We established a supportive care team, developed their respective responsibilities, and improved the workflow. During the treatment and follow-up period, the team carried out supportive care from the aspects of physiological, psychological and social needs, and summarized and analyzed the practice methods and effects of supportive care. Results: The incidences of anxiety and depression in the observational group were significantly lower than those in the control group one month and three months after operation, and the degree of occurrence was also significantly lower than that in the control group. The incidences of social avoidance and self-esteem in the observation group were significantly lower than those in the control group in 1 and 3 months after operation (P < 0.05). The incidences of upper limb lymphedema in the observation group were significantly lower than those in the control group in 1 month and 3 months after operation, and the degree of occurrence was also significantly lighter than that in the control group. Conclusion: Supportive care based on NLP technology can significantly reduce the incidence and degree of anxiety and depression in breast cancer patients, and also reduce the incidence of upper limb lymphedema. Therefore, the application model of supportive care based on NLP technology in lymphedema and negative emotion intervention of breast cancer patients after operation is worthy of reference and promotion.

Objective: To investigate the application value of ultrasound-guided preciselocalization of carbon nanoparticles in thyroid microfoci resection. Methods: Sixty patients with thyroid microlesions classified as class III or above by Tl-RADS were collected and randomly divided into experimental group (n = 30) and control group (n = 30). The experimental group was treated with ultrasound-guided carbon nanoscale staining for precise localization and surgical resection, while the control group was treated with ultrasound localization and surgical resection. The time of complete lesion resection, intraoperative blood loss, success rate of oneprecise lesion resection and the amount of tissue excised were compared between the two localization methods. Results: In the experimental group, the time of complete resection was (18.10 ± 5.81) min, the amount of intraoperative bloodloss was (20.30 ± 8.71) ml, the weight of resected tissue was (15.8 ± 6.6) g, and the success rate of one accurate resection was 96.6% (29/30). In the controlgroup, the time of complete resection was (18.10 ± 5.81) min, the amount of intraoperative blood loss was (30.20 ± 10.70) ml, the weight of resected tissue was (28.50 ± 9.30) g, and the success rate of one precise resection was 76.6% (23/30). The time to find the lesion in the experimental group was significantly shorter than that in the control group (P < 0.05). The intraoperative blood loss, the amount of resected tissue and the success rate of mass localization in the experimental group were significantly better than those in the control group (P< 0.05). Conclusions: Compared with ultrasound localization, ultrasound-guided preciselocalization of nano-carbon staining can help surgeons to quickly and accurately find thyroid microlesions during operation, reduce the amount of normal thyroid tissue removed, and improve the success rate of surgery.