Journal of Pain Research

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ISSN / EISSN : 11787090 / 11787090
Current Publisher: Dove Medical Press Ltd. (10.2147)
Total articles ≅ 1,285
Google Scholar h5-index: 36
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Journal of Pain Research; doi:10.2147/jpr

Abstract:An international, peer reviewed, open access, online journal that welcomes laboratory and clinical findings in the fields of pain research and the prevention and management of pain. Original research, reviews, symposium reports, hypothesis formation and commentaries are all considered for publication.
Enrico Polati, Pier Luigi Canonico, Vittorio Schweiger, Massimo Collino
Journal of Pain Research, Volume 12, pp 1569-1576; doi:10.2147/jpr.s190154

Abstract:Tapentadol: an overview of the safety profile
Giuseppe Rinonapoli, Stefano Coaccioli, Lorenzo Panella
Journal of Pain Research, Volume 12, pp 1529-1536; doi:10.2147/jpr.s190161

Abstract:Tapentadol in the treatment of osteoarthritis: pharmacological rationale and clinical evidence
Piotr Kamieniak, Joanna Bielewicz, Jacek Kurzepa, Beata Daniluk, Joanna Kocot, Tomasz Trojanowski
Journal of Pain Research, Volume 12, pp 1457-1464; doi:10.2147/jpr.s201199

Abstract:The impact of changes in serum levels of metalloproteinase-2 and metalloproteinase-9 on pain perception in patients with disc herniation before and after surgery
Lining Wu, Liangchun Wu, Hao Sun, Chunshan Dong, Junma Yu
Journal of Pain Research, Volume 12, pp 1433-1439; doi:10.2147/jpr.s203721

Abstract:Effect of ultrasound-guided peripheral nerve blocks of the abdominal wall on pain relief after laparoscopic cholecystectomy Lining Wu,1 Liangchun Wu,2 Hao Sun,1 Chunshan Dong,1 Junma Yu11Department of Anesthesiology, The First People’s Hospital of Hefei, Anhui Medical University, Hefei 230061, People’s Republic of China; 2Department of Anesthesiology, Anhui Provincial People‘s Armed Police General Hospital, Hefei 230041, People’s Republic of ChinaPurpose: The aim of this study was to compare the effect of an ultrasound-guided transversus abdominis plane block (TAPB) and rectus sheath block (RSB) combination, an ultrasound-guided posterior TAP block combined with the local anaesthetic infiltration (LAI) and LAI alone on pain relief after laparoscopic cholecystectomy (LC).Patients and methods: One hundred eighty patients who were American Society of Anesthesiologists class &Igr; or Π were included in this randomized, double-blind, non-inferiority study. All patients underwent three-port LC and were divided into 3 groups. The LAI group had ropivacaine mixed with dexmedetomidine injected around the trocar entrance site preoperatively. The TL group underwent ultrasound-guided posterior TAPB combined with LAI, and the TR group underwent ultrasound-guided TAPB combined with RSB. Postoperative pain was evaluated at the first, 4th, 8th, 24th, and 48th hours. If the visual analogue scale (VAS) score (including incisional pain, visceral pain or shoulder pain) was >3, intravenous dezocine (0.05 mg/kg) was injected slowly. Sleep quality, total consumption of dezocine and time to unassisted walking were recorded. The Global Satisfaction Score (GSS) for analgesia was also assessed within 48 hrs.Results: No difference was found in sleep quality, time to unassisted walking, or requirement for dezocine. We also found no difference in VAS scores at each time point within 48 hrs after LC among the 3 groups, but the GSS for analgesia in the LAI group was significantly increased within 48 hrs compared with the other two groups.Conclusion: Ultrasound-guided peripheral nerve blocks of the abdominal wall can significantly relieve postoperative pain in patients undergoing LC; however, patients receiving LAI expressed more satisfaction than patients in whom other methods were used. LAI is an easy and effective method that can be recommended for routine clinical practice in LC patients who are not converted to an open procedure.Keywords: laparoscopic cholecystectomy, postoperative pain, local anaesthetics, TAPB, trocar-site anaesthesia
Ulises Coffeen, Marco Antonio Sotomayor-Sobrino, Ariadna Jiménez-González, Luis Gerardo Balcazar-Ochoa, Pamela Hernández-Delgado, Ana Fresán, Ricardo Plancarte-Sánchez, Daniela Arias-Muñoz, Abraham Ochoa-Aguilar
Journal of Pain Research, Volume 12, pp 1331-1339; doi:10.2147/jpr.s186107

Abstract:Chemotherapy-induced neuropathic pain characteristics in Mexico's National Cancer Center pain clinic Ulises Coffeen,1 Marco Antonio Sotomayor-Sobrino,2,3 Ariadna Jiménez-González,2,3 Luis Gerardo Balcazar-Ochoa,3 Pamela Hernández-Delgado,3 Ana Fresán,1 Ricardo Plancarte-Sanchez,4 Samantha Daniela Arias-Muñóz,5 Abraham Ochoa-Aguilar2,61Laboratorio de Neurofisiología Integrativa. Investigaciones en Neurociencias y División de Investigación Clínica, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Clinical Research Division, Mexico City, Mexico; 2Hospital Loma Linda, Translational Research Laboratory, Naucalpan, Mexico; 3Universidad Nacional Autónoma de México, Faculty of Medicine, Mexico City, Mexico; 4Instituto Nacional de Cancerología, Clínica de dolor, Tlalpan, Mexico; 5Universidad Anahuac Norte, Faculty of Medicine, Huixquilucan Mexico, Huixquilucan, Mexico; 6Universidad La Salle, Mexican Faculty of Medicine, Mexico City, MexicoIntroduction: Chemotherapy (CT) is one of the most commonly used pharmacological approaches in cancer treatment. However, CT induces damage to several tissues causing significant deleterious effects in cancer survivors being chemotherapy-induced neuropathic pain (CINP) among the most commonly reported. CINP is thought to be present in up to 68.1% of the patients within 1 month of receiving CT. Due to the fact that reliable statistic information is scarce in several Latin American countries’ diagnosis and treatment of this side-effect may be delayed directly affecting patients. Therefore, the aim of the present study was to determine and present the incidence and features of CINP in patients with cancer attending the Pain Management Clinic at Mexicos’ National Institute of Cancerology in Mexico City.Methods: We performed a retrospective, file-based analysis of all the patients treated in the Pain Management Clinic at the National Institute at Cancer in Mexico from January 2016 to January 2017.Results: CINP was found in 30.9% of the patients. The basal VAS was on average 2.5 upon arrival to the Pain Management Unit and 2.4 at the end of treatment (p>0.05). The patients with the highest risk of developing CINP were those treated with paclitaxel Odds ratio 8.3 (p
Toshihiko Taguchi, Kazutaka Nozawa, Bruce Parsons, Tamotsu Yoshiyama, Nozomi Ebata, Ataru Igarashi, Koichi Fujii
Journal of Pain Research, Volume 12, pp 1411-1424; doi:10.2147/jpr.s191906

Abstract:Effectiveness of pregabalin for treatment of chronic cervical radiculopathy with upper limb radiating pain: an 8-week, multicenter prospective observational study in Japanese primary care settings
Anca Chiriac, Adrian Naznean, Cosmin Moldovan, Cristian Podoleanu, Simona Stolnicu, Anca Chiriac, Anca E. Chiriac
Journal of Pain Research, Volume 12, pp 1475-1477; doi:10.2147/jpr.s199124

Doyeon Kim, Ji Seon Jeong, HuiGyeong Park, Ki-Sun Sung, Soo Joo Choi, Mi Sook Gwak, Gaab Soo Kim, Tae Soo Hahm, Justin Sangwook Ko
Journal of Pain Research, Volume 12, pp 1479-1487; doi:10.2147/jpr.s195745

Abstract:Postoperative pain control after the use of dexmedetomidine and propofol to sedate patients undergoing ankle surgery under spinal anesthesia: a randomized controlled trial Doyeon Kim,1 Ji Seon Jeong,1 Huigyeong Park,1 Ki-Sun Sung,2 Soo Joo Choi,1 Mi Sook Gwak,1 Gaab Soo Kim,1 Tae Soo Hahm,1 Justin Sangwook Ko11Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; 2Department of Orthopedics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaBackground: Dexmedetomidine is widely used for conscious sedation in patients undergoing lower-extremity surgery under regional anesthesia. We evaluated the postoperative analgesic effects of intravenous dexmedetomidine given during ankle surgery under spinal anesthesia.Methods: Forty-three participants underwent repair of lateral angle ligaments under spinal anesthesia. For sedation during surgery, participants were allocated to a dexmedetomidine group (n=22) that received a loading dose of 1 mcg.kg−1, over 10 min, followed by a maintenance dose of 0.2–0.7 μg.kg−1,.h−1,; and a propofol group (n=21) that received an effective site concentration of 0.5–2.0 μg.mL−1, via target-controlled infusion. The primary outcome was the postoperative, cumulative, intravenous (IV) morphine equivalent dose delivered via IV patient-controlled anesthesia (PCA) and rescue analgesic consumption in the first 24 h after surgery. We recorded sensory and motor block durations.Results: The postoperative IV morphine equivalent dose was 14.5 mg (0.75–31.75 mg) in the dexmedetomidine group compared to 48.0 mg (31.5–92.5 mg) in the propofol group (median difference, 33.2 mg; 95% confidence interval, 21.0–54.8 mg; P
Feifei Shen, Xin Dong, Xin Zhou, Lanyun Yan, Qi Wan
Journal of Pain Research, Volume 12, pp 1489-1495; doi:10.2147/jpr.s196705

Abstract:Corneal subbasal nerve plexus changes in patients with episodic migraine: an in vivo confocal microscopy study Feifei Shen,1,* Xin Dong,1,* Xin Zhou,2 Lanyun Yan,1 Qi Wan11Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, People’s Republic of China; 2Department of Ophthalmology, The Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, People’s Republic of China *These authors contributed equally to this workBackground and purpose: It has been generally thought that activation and sensitization of the trigeminovascular system may contribute to the pathogenesis of migraine. Nevertheless, there is little evidence on abnormalities in peripheral trigeminal afferent nerves from humans in vivo. Alterations of corneal nerves from the ophthalmic branch of the trigeminal nerve may support the notion that trigeminal afferent nerves are involved in migraine pathophysiology. The aim of the present study was to investigate the structural changes in corneal subbasal nerve plexus in patients with episodic migraine (EM) with in vivo confocal microscope (IVCM).Methods: In this cross-sectional observational study, 10 EM patients and 10 age- and sex-matched healthy controls were included. Analysis of IVCM images with Image J software was performed to quantify the changes in the corneal subbasal nerve plexus.Results: EM patients showed an increase in nerve fiber length (25.0±2.65 vs 22.3±2.41 mm/mm,2 p=0.047) and nerve fiber density (36.3±7.29 vs 30.5±6.19 fibers/mm,2 p=0.104) as compared with normal controls, but this difference was not statistically significant. Nerve branching and tortuosity were significantly increased in the EM subjects compared to the normal subjects (91.3±13.8 vs 75.0±14.2 branches/mm,2 p=0.030 and 2.30±0.46 versus 1.63±0.52, p=0.011, respectively). In addition, nerve sprouts and increased number of Langerhans cells were observed in the EM patients.Conclusion: The morphologic changes of corneal subbasal nerve plexus and Langerhans cell aggregation suggest the presence of nerve regeneration and inflammation in EM. Furthermore, the alterations of corneal nerves from the ophthalmic branch of the trigeminal nerve offer support for the hypothesis that the peripheral trigeminal system may be involved in the pathogenesis of migraine.Keywords: migraine, corneal nerves, subbasal nerve plexus, in vivo confocal microscopy