Head and Neck Tumors (HNT)

Journal Information
ISSN / EISSN : 2222-1468 / 2411-4634
Current Publisher: Publishing House ABV Press (10.17650)
Total articles ≅ 241
Current Coverage
SCOPUS
DOAJ
Archived in
SHERPA/ROMEO
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M. A. Krylovetskaya, I. G. Komarov, A. Yu. Kontsevaya, O. A. Malikhova
Head and Neck Tumors (HNT), Volume 10; doi:10.17650/2222-1468-2020-10-4-10-15

Abstract:
Background. The detection of primary tumor in patients with cervical lymph node metastases without the primary tumor found is very important, because its location often determines the treatment strategy. The study objective is to analyze the capabilities of upper respiratory tract fibroscopy for the detection of primary tumor in patients with cervical lymph node metastases from squamous-cell carcinoma without the primary tumor found.Materials in methods. A total of 70 patients with cervical lymph node metastases without the primary tumor found, in whom cytological examination of biopsy specimens collected from cervical lymph nodes revealed squamous-cell carcinoma, underwent upper respiratory tract fibroscopy in N.N. Blokhin National Medical Research Center of Oncology between January 2017 and May 2020.Results. In 24 out of 70 patients, fibroscopy helped to identify the primary tumor and collect biomaterial for morphological examination. Twelve patients were found to have oropharyngeal cancer; ten patients were diagnosed with nasopharyngeal cancer; and 2 patients had laryngopharyngeal cancer. Fifteen out of 24 patients had tumors less than 1.2 cm.Conclusion. Upper respiratory tract fibroscopy is a highly effective method for detecting small asymptomatic tumors. It can be recommended for the examination of patients with metastases from squamous-cell carcinoma without the primary tumor found, if the primary tumor is believed to be located in the upper respiratory tract
R. V. Lutovinin, V. N. Oshchepkov, Yu. A. Shubina, V. V. Kokareva
Head and Neck Tumors (HNT), Volume 10; doi:10.17650/2222-1468-2020-10-4-91-97

Abstract:
Introduction. Surgery is frequently preferable to therapy as it yields longer overall and recurrence-free survival. But surgery of locally advanced tumors of the oral cavity can not always guarantee preservation of oral functions. In the EORTC 24971 and RTOG 90-03 trials, effectiveness of conventional radiotherapy was demonstrated. Addition of brachytherapy allowed to double recurrence-free and overall survival. Implementation of proton therapy increased treatment safety. However, high cost of modern technology for radiotherapy limits its accessibility. Intra-arterial chemotherapy is characterized by lower toxicity. Additionally, it allows to create a pool for the 1st cycle of systemic circulation directly in the tumor and neighboring tissues, and a significant portion of the drug enters the draining lymph node replicating lymphogenic metastasis.The objective was to present a clinical case of successful treatment of inoperable squamous-cell carcinoma of the oropharynx using intra-arterial chemoradiotherapy.Clinical case. A patient sought medical help at the multidisciplinary clinical medical center “Medical City” where combination treatment was chosen: a course of chemoradiation therapy using an original approach combining external beam 3D-conformal radiotherapy and intraarterial chemotherapy. According to control computed tomography data, dynamics was described as partial response: 30 % reduction in marker lesions. The patient did not have any complaints and evaluated their quality of life as high which corresponded to the testing results.Conclusion. We have demonstrated benefits of intra-arterial chemoradiation therapy: low toxicity allows patients to receive a full course of radiotherapy without breaks and achieve high functional results. Considering palliative status of the patient, we did not aim to increase recurrence-free period but the objective of ensuring satisfactory quality of life was achieved. New, more physiological regimens of intra-arterial infusion will improve pharmacokinetic profile of chemotherapeutic drugs and will allow to achieve positive results.
A. M. Mudunov, E. G. Khazarova, Yu. V. Alymov
Head and Neck Tumors (HNT), Volume 10; doi:10.17650/2222-1468-2020-10-4-86-90

Abstract:
Skin cancer of external ear is a very aggressive type of cancer with spread to the parotid gland, bone structures of the lateral skull base, meninges and brain tissue. At the same time, malignant tumors of the external ear are very rare disease, accounting for 0.2 % of all malignant head and neck tumors. This fact explains the small amount of investigation in this scientific field. Now, does not exist unanimous opinion about the treatment tactics for patient with locally advanced ear cancer. Surgical tactics for volumes of block resections of the temporal bone are different. Controversial issues relate to the appropriateness of surgical treatment in general in the case of advanced tumor process. In this article we performed publication analysis devoted to selection of optimal treatment tactics for patient with locally advanced ear cancer.
N. V. Severskaya, A. A. Ilyin , I. V. Chebotareva, N. V. Zhelonkina, V. V. Polkin, P. A. Isaev , D. N. Derbugov, S. O. Podvyaznikov
Head and neck tumors (HNT), Volume 10; doi:10.17650/2222-1468-2020-10-3-19-26

The publisher has not yet granted permission to display this abstract.
S. I. Kutukova, Evgeny N. Imyanitov , G. A. Raskin, Yu. V. Ivaskova, N. P. Beliak, Andrey I. Yaremenko , A. Ya. Razumova , P. M. Baykalova
Head and neck tumors (HNT), Volume 10; doi:10.17650/2222-1468-2020-10-3-65-71

The publisher has not yet granted permission to display this abstract.
A. M. Mudunov , A. V. Ignatova, A. S. Morozova, S. O. Podvyaznikov, Yuri Alymov
Head and neck tumors (HNT), Volume 10; doi:10.17650/2222-1468-2020-10-3-111-117

The publisher has not yet granted permission to display this abstract.
A. M. Mudunov , M. B. Pak, L. V. Demidov, K. A. Baryshnikov
Head and neck tumors (HNT), Volume 10; doi:10.17650/2222-1468-2020-10-3-55-64

The publisher has not yet granted permission to display this abstract.
E. V. Borodavina, P. A. Isaev, F. S. Sevrukov, A. V. Sidorin, V. V. Polkin, A. A. Ilyin, N. V. Severskaya, T. A. Agababyan, S. A. Ivanov , A. D. Kaprin
Head and neck tumors (HNT), Volume 10; doi:10.17650/2222-1468-2020-10-3-48-54

The publisher has not yet granted permission to display this abstract.
A. P. Polyakov, Pavel O. Rumyantsev , P. A. Nikiforovich , А. В. Мордовский , E. A. Chistyakova
Head and neck tumors (HNT), Volume 10; doi:10.17650/2222-1468-2020-10-3-12-18

The publisher has not yet granted permission to display this abstract.
A. O. Eremina, I. A. Zaderenko, Sergey Yu. Ivanov , S. B. Alieva, A. B. Dymnikov, A. V. Khromushina, B. C. Pkheshkhova
Head and neck tumors (HNT), Volume 10; doi:10.17650/2222-1468-2020-10-3-72-80

Abstract:
Oral mucositis is one of the most common effects of chemoradiotherapy in patients with oropharyngeal cancer. The development of oral mucositis is the main cause of interruption of antitumor therapy, which significantly affects the results of treatment of the main disease. Despite the fact that the disease is well studied in the literature, today there is no universal treatment and prevention protocol. The aim of this review is to analyze scientific publications devoted to the problems of etiology, pathogenesis, clinic, diagnosis, treatment and prevention of oral mucositis.
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