Japanese Journal of Medicine

Journal Information
ISSN / EISSN : 0021-5120 / 1881-123X
Published by: Japanese Society of Internal Medicine (10.2169)
Total articles ≅ 1,582
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Tadanori Nagai, Rhyuzou Koyama, Yutaka Sasagawa, Shuji Matsumoto, Yohoshiro Niisu, Shin-Ichi Takayama, Toshiya Murakami, Akihiro Matsuura
Japanese Journal of Medicine, Volume 30, pp 57-63; https://doi.org/10.2169/internalmedicine1962.30.57

A 55-year-old man with a chief complaint of melena had diffusely infiltrated lymphoma from the rectum to the sigmoid colon and polyclonal hypergammaglobulinemia. Biopsy specimen obtained from the rectum revealed diffuse medium-sized lymphoma cell with plasmocytosis. Histochemical analysis with monoclonal antibodies indicated that the origin of the tumor cell to be T-lymphocyte. Chemotherapy with cyclophosphamide, vincristine and prednisolone (VEP regimen) was effective for mucosal bleeding of the colonic lesion and reduction of polyclonal hypergammaglobulinemia. Five yrs later he showed recurrence of the disease and elevation of serum alphafetoprotein, and died of pulmonary infections. Autopsy finding confirmed the diagnosis of malignant lymphoma of the colon and disclosed the association of hepatocellular carcinoma.
Katsuya Obara, , Hiroshi Sato, Kei Yamakage, Takao Watanabe, Miho Kakizawa, Tetsuro Tsukamoto, Kazuo Kobayashi, Michio Hongo, Kaoru Yoshinaga
Japanese Journal of Medicine, Volume 30, pp 67-72; https://doi.org/10.2169/internalmedicine1962.30.67

We report five patients who have taken inorganic germanium preparations over a prolonged period. In all cases, the renal function deteriorated with no proteinuria or hematuria. Histological examination of the kidneys showed widespread tubular degeneration and interstitial fibrosis with minor glomerular abnormalities. Most patients had gastrointestinal symptoms such as vomiting, anorexia and weight loss; one patient had peripheral neuropathy and myopathy. A considerable amount of germanium was detected in the hair or nails of these patients. These cases clearly show that abuse of inorganic germanium compounds can induce renal damage with various extrarenal manifestations.
Shuji Katoh, Hirotaka Tatsukawa, Morihiko Kondoh, Miho Inoue, Kazunori Ida, Fujio Miyagawa
Japanese Journal of Medicine, Volume 30, pp 311-317; https://doi.org/10.2169/internalmedicine1962.30.311

The febrile reaction that occurs on reinfusion of ascites was studied. Intravenous reinfusion of ascites was performed 213 times in 63 cases of ascites, which were refractory to treatment with various drugs including diuretics. In order to prevent fever on reinfusion of ascites, a screen filter and a depth filter were used; the results were more favorable with the screen filter. Fibrin was considered to be one of the substances removable by the screen filter. HPLC analysis of the filtered and concentrated ascites, after passage through the screen filter, revealed a fraction corresponding to albumin. Intravenous injection of this fraction into rabbits caused fever. Although the screen filter cannot completely prevent fever on reinfusion of ascites, it appears useful to prevent fever in some patients.
Tetsuro Okabe, Seiichi Ishizaka, Michio Fujisawa
Japanese Journal of Medicine, Volume 30, pp 326-329; https://doi.org/10.2169/internalmedicine1962.30.326

Human trophoblastic cells (T3M-3) metabolized 25-hydroxyvitamin D3 into two more polar metabolites during in vitro incubations. A two-step high pressure liquid chromatography system revealed two unique elution positions of those trophoblastic cell-derived metabolites that exactly co-migrated with the elution positions of 5(Z)-19-nor-10-oxo-25-hydroxyvitamin D3 and 5(E)-19-nor-10-oxo-25-hydroxyvitamin D3, respectively. These unique metabolites did not bind specifically to a protein receptor for 1,25-dihydroxyvitamin D3.
Junichi Kameoka, Kazuyasu Endo, Tomohiro Sugawara, Kyoko Kaneda, Osamu Fukuhara, Kuniaki Meguro, Tadami Sakurai, Akira Miura, Kumiko Naito, Kaoru Yoshinaga, et al.
Japanese Journal of Medicine, Volume 30, pp 330-332; https://doi.org/10.2169/internalmedicine1962.30.330

A case of autoimmune hemolytic anemia associated with myasthenia gravis in a 33-year-old female is presented. The association of autoimmune hemolytic anemia and myasthenia gravis is a very rare event, with only eight cases reported. The known association of these two diseases is reviewed. To our knowledge, this is the first reported case in which autoimmune hemolytic anemia preceded systemic myasthenia gravis.
Makoto Saitoh, Junichi Hasegawa, Tom Takami, Akira Hoshio, Hiroyuki Miyakoda, Hiroshi Kotake, Hiroto Mashiba, Sadao Tsutsumi, Yoshio Katsube
Japanese Journal of Medicine, Volume 30, pp 333-337; https://doi.org/10.2169/internalmedicine1962.30.333

An 80-year-old man with Ebstein's anomaly and ductus arteriosus aneurysm is reported. He was admitted with bradycardiac atrial fibrillation and right ventricular failure. For the control of brady-arrhythmia, a permanent pacemaker was implanted. Two-dimensional echocardiogram revealed distal displacement of the septal tricuspid valve. Aortography and computed tomography showed ductus arteriosus aneurysm. This is the first report of the association of Ebstein's anomaly and non-patent ductus arteriosus aneurysm.
Naohiko Inase, Shigemitsu Takayama, Morito Nakayama, Hirotaro Miura, Yuji Kimula
Japanese Journal of Medicine, Volume 30, pp 343-345; https://doi.org/10.2169/internalmedicine1962.30.343

A 38-year-old woman with pleural mesothelioma who had a history of neighborhood asbestos exposure during her childhood was demonstrated. She had no known history of occupational asbestos exposure. This is the first case of mesothelioma with neighborhood asbestos exposure reported in Japan. Previously-reported cases of mesothelioma with neighborhood asbestos exposure in the English language literature were reviewed.
Kazuo Ichikawa, Masahide Watanabe, , Takahide Miyamoto, Atsushi Momose, Motoji Naka, Masatsune Usuda, Kunio Yoshizawa, Kiyoshi Hashizume, Takashi Yamada
Japanese Journal of Medicine, Volume 30, pp 351-353; https://doi.org/10.2169/internalmedicine1962.30.351

A 54-year-old woman was treated for bronchial asthma for 14 yr. In March of 1989, chest roentgenography and computed tomography (CT) revealed development of bilateral pulmonary hilar lymph node enlargement. Positive 67Ga uptake was observed in bilateral pulmonary hili. Although levels of serum angiotensin converting enzyme (ACE) and lysozyme were within normal range, biopsy specimen of scalene lymph nodes showed noncaseating epitheloid-cell granuloma, leading to the diagnosis of sarcoidosis. Steroid therapy ameliorated both sarcoidosis and bronchial asthma. Although the association of sarcoidosis and bronchial asthma is uncommon, there may be an etiological relationship between them.
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