Microbiology Spectrum

Journal Information
ISSN / EISSN : 2165-0497 / 2165-0497
Published by: American Society for Microbiology (10.1128)
Total articles ≅ 1,296
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Hui Xia, Yang Zheng, Dongxin Liu, Shengfen Wang, Wencong He, Bing Zhao, Yuanyuan Song, Xichao Ou, Yang Zhou, Susan Van Den Hof, et al.
China is one of the high-burden countries for multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB). Moxifloxacin is one of the critical antituberculosis drugs for MDR/RR-TB treatment.
Cheng-Yun Hsu, Yi-Lun Wu, Hsueh-Chun Lin, Man-Yi Lin, Shih-Hsiu Chou, Chung-Wai Shiau, Hao-Chieh Chiu
The incidence of diseases caused by pathogenic bacteria with resistance to common antibiotics is consistently increasing. In addition, Gram-negative bacteria are particularly difficult to treat with antibiotics, especially those that can invade and proliferate intracellularly.
Allyson G. Costa, Brenda K. S. Carvalho, Mariana Araújo-Pereira, Hiochelson N. S. Ibiapina, Renata Spener-Gomes, Alexandra B. Souza, Adriano Gomes-Silva, Alice M. S. Andrade, Elisangela C. Silva, María B. Arriaga, et al.
The IGRA has emerged as a useful tool for identifying persons with LTBI. Although the implementation of IGRAs is of utmost importance, to our knowledge there is scarce information on the identification of logistical and technical challenges for systematic screening for LTBI on a large scale.
, Yang Liu, Yong Chen, Fu-Man Huang, Rong-Chang Chen, ,
Recently identified plasmid-borne tet (X) genes have greatly challenged the efficiency of tigecycline, a last-resort antibiotic for severe infection, while the dissemination pattern of the plasmid-borne tet (X) genes remains unclear. In this study, we identified a clonal dissemination of tet (X3)-positive A. towneri isolates on a swine farm, while the tet (X6)-positive A. towneri strains mainly disseminated sporadically on the same farm.
, Jang-Jih Lu, Lee-Chung Lin, Hsiao-Chi Lin, Shih-Cheng Chang
CRISPR-Cas systems have been characterized as playing several biological roles in many bacterial genomes. Moreover, CRISPR-Cas systems are useful for epidemiological, diagnostic, and evolutionary studies of pathogenic bacteria.
Pseudomonas aeruginosa was shown previously to attack amoebae and other predators by adhering to them and injecting them with virulent substances. In this work, we show that an active, coordinated group behavior is enacted by the bacteria to utilize these molecular components, responding to both predator and bacterial population density.
Kangqi Wu, Yongtao Xu, Weiwei Zhang, Huirong Mao, Biao Chen, Yunlin Zheng,
We used a metagenomic approach to investigate whether and how captive and free-range impact the microbial communities and antimicrobial resistance in sika deer. The results provide solid evidence of the significant impacts on the microbial composition and function in captive and free-range sika deer. Interestingly, although the sika deer had the same exposure to antibiotic anthelmintics, the antimicrobial resistances were affected by the breeding environment.
Hitoshi Kawasuji, , , Yumiko Saga, Makito Kaneda, Yushi Murai, Akitoshi Ueno, Yuki Miyajima, Yasutaka Fukui, Kentaro Nagaoka, et al.
Since mRNA vaccines utilize wild-type SARS-CoV-2 spike protein as an antigen, there are potential concerns about acquiring immunity to variants of this virus. The neutralizing activity in BNT162b2-vaccinated individuals was higher against the wild-type virus than against its variants; this effect was more apparent in older age groups.
, , Yasushi Terasaki, Satoshi Nomura, Hitoshi Kawasuji, Takahisa Shimada, Emiko Igarashi, Yumiko Saga, Yoshihiro Yoshida, Rei Yasukochi, et al.
This study provides a diagnostic evidence of test validity, which can lead to vaccine efficacy and proof of recovery after COVID-19. It is not easy to know neutralization against SARS-CoV-2 in the clinical laboratory because of technical and biohazard issues.
Jun Mao, Ting Li, Na Zhang, Shuaishuai Wang, Yaowen Li, Yu Peng, Huiping Liu, Guang Yang, Yisong Yan, Lifang Jiang, et al.
In this study, we found that linezolid combined with fosfomycin could kill Enterococcus in vitro and that the administered dose was significantly lower after the combination treatment, which could reduce adverse effects and the development of drug resistance. The potential mechanism of the two-drug combination against Enterococcus was revealed from a quantitative perspective, which is an important step toward dose optimization in simulated humans.
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