Transplantologiya. The Russian Journal of Transplantation

Journal Information
ISSN / EISSN : 2074-0506 / 2542-0909
Current Publisher: IPO Association of Transplantologists (10.23873)
Total articles ≅ 94
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Latest articles in this journal

E. V. Parabina, B. I. Yaremin, Michael M. Kaabak
Transplantologiya, Volume 12; doi:10.23873/2074-0506-2020-12-3-213-219

A case of a long-term management of a patient with Kaposi’s sarcoma developed as presumably related to a “standard” immunosuppressive therapy after kidney transplantation has been described. Immunosuppressive therapy conversion to mTOR receptor inhibitors and administering chemotherapy with prospidium chloride allowed for a long-term remission of the disease and a satisfactory clinical outcome.
S. V. Zybleva, S. L. Zyblev, V. N. Martinkov
Transplantologiya, Volume 12; doi:10.23873/2074-0506-2020-12-3-189-198

Introduction. One of the main problems in transplantology is the detection of simple, reliable and non-invasive markers that could predict adverse immune reactions and adjust immune suppressive therapy in allograft recipients in a timely manner. Objective. To determine the immunological criteria for the prediction of a graft dysfunction. Material and methods. We have examined 197 recipients who underwent kidney transplantation. All of them were immunologically examined with the identification of more than 40 subpopulations of leukocytes. Allograft function was assessed on day 7 with the division of patients into two groups: with either primary or graft dysfunction. Simple and multiple logistic regressions were used to predict a graft dysfunction. Preliminary statistical analysis was performed using nonparametric statistics. Results and discussion. A scoring system to predict the graft function has been worked out. At CD19+IgD+CD27- 72.7%. At CD3+CD8+CD69+>9.7% score 1 is assigned, and 0 score is given at CD3+CD8+CD69+1 predicts a graft dysfunction. This scoring system has the sensitivity of 91.9%, еру specificity of 100%, еру accuracy of 94.9%, positive predictive value of 1 and negative predictive value of 0.877. Conclusions. 1. Percentage of CD19+IgD+CD27- and CD3+CD8+CD69+ subpopulations can be used to predict a graft dysfunction. 2. At values of CD19+IgD+CD27- not exceeding 72.7% and CD3+CD8+CD69+ more than 9.7%, the development of a graft dysfunction can be anticipated.
M. Sh. Khubutiya, S. E. Voskanyan, V. E. Syutkin, V. P. Chulanov, M. S. Novruzbekov, V. D. Pasechnikov, V. L. Korobka, O. O. Rummo, E. N. Bessonova, S. F. Bagnenko, et al.
Transplantologiya, Volume 12; doi:10.23873/2074-0506-2020-12-3-231-244

Рекомендации по профилактике и лечению инфекций вирусами гепатита В и С у больных, находящихся в Листе ожидания трансплантации печени, и реципиентов печени
E. V. Migunova, Е. А. Tarabrin, N. E. Kudryashova, O. G. Sinyakova, N. A. Karchevskaya, A. G. Petukhova, A. A. Saprin, T. E. Kallagov
Transplantologiya, Volume 12; doi:10.23873/2074-0506-2020-12-3-174-188

Study objective. Evaluation of the possibilities of ventilation and perfusion scintigraphy in detecting functional disorders and determining the severity of lung damage that may occur after organ transplantation. Material and methods. The study included 27 patients after bilateral lung transplantation; mucoviscidosis was the main cause of terminal respiratory failure in most cases (19 patients; 77.8%). The ventilation scintigraphy was performed with 99mTc-pentatech using a nebulizer, and the perfusion scintigraphy was performed with 99mТс-albumin macroaggregate. The investigations were performed on Infinia II and Discovery 670 NM/CT single-photon emission tomographs (GE, USA). Results. Changes in the quantitative parameters of ventilation and perfusion scintigraphy in patients after lung transplantation were studied. When analyzing the results of radionuclide studies, we identified a restoration of function after lung transplantation, and the appearance of disorders with the development of complications in the early (up to 4 months) and later (more than one year) periods after bilateral lung transplantation. Conclusion. The study has shown that the radionuclide method has wide possibilities for assessing the ventilation and perfusion functions in patients after lung transplantation, helping in the differential diagnosis of obliterating bronchiolitis and graft vascular sclerosis, in assessing the nature of alveolar-capillary diffusion disorders, and determining the extent of functional abnormalities in every individual patient. Monitoring the function of transplanted lungs using scintigraphy allows separate monitoring of ventilation and perfusion changes, which is important for the choice of treatment tactics.
P. A. Brygin, S. V. Zhuravel, D. A. Troitskiy, I. I. Utkina
Transplantologiya, Volume 12; doi:10.23873/2074-0506-2020-12-3-220-230

The purpose of this article is to describe the problem of predicting the lung function recovery in patients with extracorporeal membrane oxygenation for acute respiratory distress syndrome. Data from CESAR and EOLIA clinical trials on the efficacy of extracorporeal membrane oxygenation in patients with acute respiratory distress syndrome have been reviewed and some controversial results discussed. The prognostic PRESERVE and RESP scores developed as prognostic tools on the basis of the results of these studies, are presented, the limitations of their applicability in various forms of acute respiratory distress syndrome are discussed. We propose to subdivide the predictors of the extracorporeal membrane oxygenation outcome in patients with acute respiratory distress syndrome into 4 following groups: 1. Lung injury severity criteria, including parameters of their lung mechanical and functional properties. 2. Time from acute respiratory failure onset to extracorporeal membrane oxygenation initiation, which reflects the rate of pathological processes in lungs and timing of decision to initiate extracorporeal membrane oxygenation. 3. The etiology of pulmonary disorders, directly affecting the reversibility of pathological processes in the lungs. 4. The severity of the patient's general condition, including the severity of manifestations of multiple organ failure, the degree of decompensation of concomitant chronic diseases, including oncological and associated with immunosuppression. Several diseases are associated with a higher risk of specific complications, particularly hemorrhagic, during extracorporeal membrane oxygenation.
I. Yu. Kolyshev, S. E. Voskanyan, M. V. Shabalin, A. I. Artemyev, V. S. Rudakov, A. P. Maltseva, A. N. Bashkov, V. E. Syutkin, K. K. Gubarev, D. S. Svetlakova, et al.
Transplantologiya, Volume 12; doi:10.23873/2074-0506-2020-12-3-199-212

Background. Cancer occurring in recipients of living donor liver transplantation may be characterized by a progressive course requiring an immediate specialized treatment initiation and adjustment of immunosuppression regimen. Aim. To specify the malignancy development mechanisms and risk factors in the recipients of living donor liver transplantation. Material and methods: 275 living donor liver transplantations were made in Burnasyan Federal Medical Biophysical Center of FMBA from 2010 to 2020. Forty two (15.27 %) patients underwent surgery for hepatocellular carcinoma. The median time to the onset of malignancy development was estimated. The incidence of malignancy in general population and in recipients of living donor liver transplantation was compared. Results. The development of neoplastic lesion was registered in 9 cases (3.27%). Malignances were detected in 8 cases (2.90%). Median time to the onset of malignancy development was 48 months. 1, 3, and 5 year overall survival rates were 97%, 96%, 94%;respectively; 1, 3, and 5 year survival rates after transplantation for hepatocellular cancer were 97%, 91%, 91% respectively. Survival rate of patients with De-novo malignancy was 90%. Conclusion. Recipients of living donor liver transplantation have an increased risk of malignancy development that requires a close long-term follow-up.
Transplantologiya, Volume 12; doi:10.23873/2074-0506-2020-12-3-245-258

The article has described, analyzed, and introduced into scientific circulation some previously unknown facts from V.P. Demikhov's life, namely, his nomination as a Corresponding Member to the USSR Academy of Sciences in the specialty "physiology" in May, 1966, and his experimental and research work in 1966. The inspection of his scientific activities undertaken on behalf of the Academic Council of N.V. Sklifosovsky Institute for Emergency Medicine, showed that the discoveries and achievements V.P. Demikhov had made in the field of physiology were significant, and he was worthy of being nominated for the rank of a Corresponding Member to the USSR Academy of Sciences. However, he lacked several votes for being elected to the Academy. Meanwhile, in 1966 V.P. Demikhov continued his unique research, having initiated studying the coronary blood flow of the transplanted heart, implementing immunosuppression in kidney transplantation, and starting the experiments on creating a bank of organs to preserve their functions before transplantation.
V. E. Syutkin, N. V. Borovkova, M. S. Novruzbekov
Transplantologiya, Volume 12; doi:10.23873/2074-0506-2020-12-2-126-134

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S. V. Zhuravel, N. K. Kuznetsova, I. I. Utkina, M. S. Novruzbekov, P. V. Gavrilov, T. V. Chernenkaya, G. K. Ospanova
Transplantologiya, Volume 12; doi:10.23873/2074-0506-2020-12-2-104-111

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