Photonics & Lasers in Medicine

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ISSN / EISSN : 2193-0635 / 2193-0643
Published by: Walter de Gruyter GmbH (10.1515)
Total articles ≅ 264
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, Stephan Dymling, Jakob Axelsson
Photonics & Lasers in Medicine, Volume 5; https://doi.org/10.1515/plm-2015-0036

Abstract:
Clinical Laserthermia Systems AB (CLS) has developed a treatment protocol named immunostimulating interstitial laser thermotherapy (imILT
F. Frank, L. Lilge, C.M. Philipp, R. Sroka
Photonics & Lasers in Medicine, Volume 5, pp 5-5; https://doi.org/10.1515/plm-2015-0040

Photonics & Lasers in Medicine, Volume 5, pp 85-89; https://doi.org/10.1515/plm-2016-0010

, , Ilya Fiks, Kseniya Korchagina, Mikhail Kleshnin, Natalya Shakhova
Photonics & Lasers in Medicine, Volume 5; https://doi.org/10.1515/plm-2015-0042

Abstract:
Photodynamic therapy (PDT) has been successfully used in clinical practice for decades; however, clinical outcome data are not always consistent resulting in a great necessity for real-time monitoring to predict the therapy outcome.In a retrospective clinical study, 402 patients with non-melanoma skin malignancies were enrolled who underwent PDT treatment and fluorescence real-time imaging. The photosensitizer used was a chlorine e6 derivative (FotoditazinBaseline
Photonics & Lasers in Medicine, Volume 5; https://doi.org/10.1515/plm-2016-0001

Abstract:
Pancreatic cancer has long been a leading cause of cancer death. Few patients are suitable for surgery and for those who are not, the response to treatment is generally poor. No more than about 10% survive for more than a year. Recent research has focused on focal treatment for local disease control. This review covers the development of one of the most promising options, photodynamic therapy (PDT).This review covers pre-clinical and clinical studies. Laboratory work was designed to understand the effect of PDT on the normal pancreas and surrounding tissues and on transplanted cancers in the hamster pancreas to ensure safety prior to clinical application. Essentially all clinical studies have been undertaken in University College Hospital, London. Phase-I studies used the photosensitisers mTHPC and verteporfin in patients with localised but inoperable cancers.Laboratory results showed that normal pancreas, bile duct, liver, stomach and major blood vessels could tolerate PDT without any unacceptable effects on the structure and function of these organs. Necrosis that healed safely was documented in transplanted cancers. The clinical trials showed that focal necrosis could be produced in inoperable cancers with acceptable levels of complications, but considerable refinements of treatment delivery and monitoring are required before the technique will be ready for assessment in controlled clinical trials.PDT is showing promise for the minimally invasive treatment of localised pancreatic cancers, but it is still at an early stage of development. Much more work will be necessary to optimise techniques for applying PDT to these cancers and for combining it with other therapeutic options such as chemotherapy.
Margherita Gobbo, , Katia Rupel, , Alessandra Guglielmi
Photonics & Lasers in Medicine, Volume 5, pp 225-230; https://doi.org/10.1515/plm-2016-0009

Abstract:
Background: Patients suffering from anal cancer have to undergo different anticancer therapies, including radiotherapy. Radiodermatitis represents a debilitating side effect of radiotherapy, often leading to painful lesions and a suspension of the radiotherapy treatment. No widely recognized treatment of radiodermatitis is currently available. Objective: The present report introduces an innovative technique based on the use of laser light to manage radiodermatitis of the anal region in a decisive fashion. Study design: Two cases of radiodermatitis are presented, the occurrence of which followed combined chemoradiotherapy for anal squamous cell carcinoma. Both patients complained about strong pain, severe itch and spontaneous bleeding from the lesions. In addition, they reported limitations in their daily life activities as well as a negative impact on their quality of life. Both patients received laser irradiation therapy by applying two wavelengths simultaneously (970±15 nm and 660±15 nm) for a total of six laser sessions. The chosen treatment parameters were as follows: peak power, 6 W, 50% duty cycle for 360 s; peak power, 6 W in continuous mode for another 120 s resulting in spatially averaged energy fluences of 67.5 J/cm2 and 45 J/cm2, respectively. Results: Complete healing of the lesions and symptoms was achieved within 2 weeks. Remission of the symptoms continued after 2 months with no documented side effects. Both patients managed to complete the radiotherapy sessions and reported maximum satisfaction with the treatment. Conclusions: These cases can prepare the ground to consider class-IV laser therapy, an innovative option to manage radiodermatitis with predictable effectiveness and a consequent improvement in the quality of life of the patients. Patients experiencing radiodermatitis suffer from pain accompanied by limited independence in daily activities, decreased life quality, and reduced self-esteem which often leads to depression. Resolution of radiodermatitis can result in fewer cases of radiotherapy suspension and a better outcome in the oncological treatment as well as an improved quality of life, usually very quickly.
Hamideh Mohsenirad, , Mahmood Seifouri
Photonics & Lasers in Medicine, Volume 5; https://doi.org/10.1515/plm-2015-0033

Abstract:
In this paper, a two-dimensional photonic crystal biosensor for medical applications based on two waveguides and a nanocavity is presented. The waveguides and nanocavity are created by introducing line and point defects into a photonic crystal, respectively. It could be shown that by injecting an analyte into a sensing hole, and thus changing its refractive index, may shift the resonant wavelength. The proposed structure is designed for the wavelength range of 1.5259–1.6934 μm. Sensitivity, the most important biosensor parameter, was studied and found to be approximately equal to 83.75 nm/refractive index units (RIU). An important specification of this structure is its very small dimensions. Two-dimensional finite-difference time domain and plane-wave expansion methods were used for both to simulate the proposed structure and to obtain the band diagrams.
Alexander V. Bashenow, Igor Y. Motus, Sergey N. Skornyakow, Anton V. Neretin, Natalya V. Rayewskaya, Ilia A. Dyachkow, Roman B. Berdnikow, Lyudmila A. Golubewa
Photonics & Lasers in Medicine, Volume 5, pp 231-240; https://doi.org/10.1515/plm-2016-0020

Abstract:
Objective: A first experience of using a Nd:YAG laser with a wavelength of 1318 nm for limited forms of pulmonary tuberculosis surgery is reported. Subjects and methods: During the period from June 2013 to August 2015 a total of 32 patients (19 men and 13 women) underwent surgery for tuberculous granulomas. The average age of the patients was 37.3 years (median, 36 years; range, 18–61 years). Resections of granulomas were carried out using the laser alone (25 patients) or in combination with suturing devices (seven patients). Results: Overall 39 tuberculomas were removed from the 32 patients. The biggest growth measured 2.4×2.2×3.1 cm, while the smallest measured 0.5×0.5×0.5 cm. Overall, the average surgery time was 57 min (median, 50 min; range, 25–115 min). In the combined resection subgroup (using the laser and staplers), the average surgery time was 75 min (median, 50 min; range, 45–115 min). In the subgroup where lung resection was carried out using the laser alone, the average surgery time was 52 min (median, 45 min; range 25–95 min). Total blood loss during surgery was 53 ml (median, 45 ml; range 10–150 ml), 87 ml (median, 50 ml; range 15–150 ml) in the combined lung resection subgroup and 44 ml (median, 35 ml; range, 10–100 ml) in the laser only resection subgroup. Morphological analysis revealed the following results: a high level of tubercular activity was maintained in 12/39 (31%) resected tuberculous granulomas, a moderate level of tubercular activity was detected in 11/39 (28%) resected masses and remitting activity was identified in 16/39 (41%) resected masses. Along the laser resection line of the lung the edge of a tuberculous growth was found in 10/39 cases (26%). The average post-operative duration of pleural drainage was 3.9 days (median, 3 days; range, 2–9 days) in total, 4.1 days (median, 5 days; range, 2–6 days) in the combined subgroup and 3.8 days (median, 3 days; range, 2–9 days) in the laser-only subgroup. The number of post-operative complications assessed according to the Clavien-Dindo scale was two out of 32 patients (6.2%), with two cases of residual pleural cavities. Post operative mortality was 0%. Conclusion: Our first experience of using the Nd:YAG laser with a wavelength of 1318 nm for the resection of limited forms of tuberculosis demonstrated a high level of efficacy and excellent aero- and hemostatic properties with a low rate of post-operative complications even though the differences between the combined resection and laser-only subgroups were not statistically significant (p>0.05). However, the method is applicable in surgery of limited forms of lung tuberculosis in different variants, performing pure laser resections and as an additional method for other types of lung resections.
Photonics & Lasers in Medicine, Volume 5, pp 253-256; https://doi.org/10.1515/plm-2016-0027

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